The Kinetics of Cross-Bridge Attachment and Detachment Studied by High Frequency Stiffness Measurements

  • Giovanni Cecchi
  • Peter J. Griffiths
  • Stuart Taylor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37)


Muscle fiber stiffness, supposedly an indication of attached cross-bridges, was measured throughout tetanic contraction and subsequent relaxation. Stiffness increased at a rate faster than the development of force during the rise of tetanic contraction and decreased more slowly than force during relaxation. One explanation for these results is that long-lived cross-bridge states may exist between attachment, force generation and detachment.


Length Change Stiffness Measurement Tetanic Contraction Length Oscillation Quick Release 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Giovanni Cecchi
    • 1
  • Peter J. Griffiths
    • 2
  • Stuart Taylor
    • 3
  1. 1.Istituto di Fisiologia UmanaFlorenceItaly
  2. 2.University Laboratory of PhysiologyOxfordEngland
  3. 3.The Department of PharmacologyMayo FoundationRochesterUSA

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