Cross-Bridge States in Invertebrate Muscles

  • John S. Wray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37)


Arguments are presented for doubting whether the effect of AMPPNP on insect flight muscle in rigor signals a reversion of the power stroke of attached cross-bridges. Instead, the effect of this nucleotide on insect and other muscles may be better explained in terms of the behavior of detached bridges. Knowledge of events in the detached half of the contractile cycle may nevertheless be relevant to understanding the mechanism of energy transduction.


Thin Filament Myosin Head Power Stroke Myosin Filament Axial Distortion 
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  1. Goody, R.S., Holmes, K.C., Mannherz, H.G., Barrington-Leigh, J. & Rosenbaum, G. (1975). X-ray studies of insect flight muscle with ATP analogues. Biophys. J. 15: 687–705.PubMedCrossRefGoogle Scholar
  2. Harrington, W.F. (1979). On the origin of the contractile force in skeletal muscle. Proc. Natl. Acad. Sci. USA. 76: 5066–5070.PubMedCrossRefGoogle Scholar
  3. Haselgrove, J.C. (1975). X-ray evidence for conformational changes in the myosin filaments of vertebrate striated muscle. J. Mol. Biol. 92: 113–143.PubMedCrossRefGoogle Scholar
  4. Huxley, H.E. (1983). This volume.Google Scholar
  5. Kuhn, H.J. (1981). The mechanochemistry of force production in muscle. J. Muscle Res. Cell Motil. 2: 7–44.PubMedCrossRefGoogle Scholar
  6. Marston, S.B., Rodger, C.D. and Tregear, R.T. (1976). Changes in muscle cross-bridges when ß,7-imido ATP binds to myosin. J. Mol. Biol. 104: 263–276.PubMedCrossRefGoogle Scholar
  7. Offer, G., Couch, J., O’Brien, E. and Elliott, A. (1981). Arrangement of cross-bridges in insect flight muscle in rigor. J. Mol. Biol. 151: 663–702.PubMedCrossRefGoogle Scholar
  8. Reedy, M.K. (1968). Ultrastructure of insect flight muscle. J. Mol. Biol. 31: 155–176.PubMedCrossRefGoogle Scholar
  9. Reedy, M.K., Holmes, K.C. and Tregear, R.T. (1965). Induced changes in orientation in the cross-bridges of glycerinated insect flight muscle. Nature 207: 1276–1280.PubMedCrossRefGoogle Scholar
  10. Reedy, M.K. and Garrett, W.E. (1977). Electron microscope studies of insect flight muscle in rigor. In: Insect Flight Muscle, pp. 115–136, ed. R.T. Tregear. Amsterdam: Elsevier North Holland.Google Scholar
  11. Reedy, M.C., Reedy, M.K. and Goody, R.S. (1981). Cross-bridge structure in rigor and AMPPNP states of insect flight muscle. Biophys. J. 33: 22a.Google Scholar
  12. Shriver, J.W. and Sykes, B.D. (1981). Phosphorus-31 Nuclear Magnetic Resonance Evidence for two conformations of myosin subfragment-1 nucleotide complexes. Biochemistry 20: 2004–2012.PubMedCrossRefGoogle Scholar
  13. Tregear, R.T., Milch, J.R., Goody, R.S., Holmes, K.C. & Rodger, C.D. (1979). The use of some novel X-ray diffraction techniques to study the effect of nucleotides on cross-bridges in insect flight muscle. In: Cross-bridge Mechanism in Muscle Contraction, ed. Sugi, H. and Pollack, G.H., pp. 425–440. Tokyo: Univ. of Tokyo Press.Google Scholar
  14. Wray, J.S. (1979) Filament geometry and the activation of insect flight muscles. Nature 280: 325–326.CrossRefGoogle Scholar
  15. Wray, J.S. (1982). Organization of myosin in invertebrate thick filaments In: Basic Biology of Muscles: A Comparative Approach, ed. Twarog, B.M., Levine, R.J.C. and Dewey, M.M., New York: Raven Press.Google Scholar
  16. Wray, J.S., Vibert, P.J. and Cohen, C. (1974). Cross-bridge arrangements in Lirnulus muscle. J. Mol. Biol. 88: 343–348.PubMedCrossRefGoogle Scholar
  17. Wray, J.S., Vibert, P.J. and Cohen, C. (1978). Actin filaments in muscle: pattern of tropomyosin/troponln attachments. J. Mol. Biol. 124: 501–521.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • John S. Wray
    • 1
  1. 1.Max Planck Institute for Medical ResearchHeidelbergWest Germany

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