Quantitative Analysis

  • Francis I. Onuska
  • Francis W. Karasek


The basic principles and conditions of gas chromatography necessary for quantitative gas chromatographic analysis have been described by Novak.1 Quantitative GC analysis is always based on the previous identification of the compounds involved. In complex environment mixtures, GC analysis is preceded by a cleanup procedure to remove bulk matrix compounds that would interfere with the analysis. In this way a reliable quantitative determination at the microgram to low picogram level is possible. Quantitative analysis with GC detectors places special demands on the measurement principle used for the detector. The signal intensity depends not only on the amount of the sample but also on a number of experimental parameters of the detection system. In practice a comparative measurement of signal represented by the peak area or a peak height of the unknown substance, unknown concentration, and a standard of known concentration can be performed in several ways:
  1. 1.

    A calibration curve is drawn up of the signal as a function of the amount of substance. The unknown concentration is determined from the intensity of its signal on the standard calibration curve. Here, quantitative determination requires a comparison of two separate measurements, such as an unknown concentration and a known calibration mixture which is used as an external standard.



Control Limit Methyl Ethyl Ketone Permeation Rate External Standard Method Unknown Concentration 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Francis I. Onuska
    • 1
  • Francis W. Karasek
    • 2
  1. 1.Canada Centre for Inland WaterNational Water Research InstituteBurlingtonCanada
  2. 2.University of WaterlooWaterlooCanada

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