Hypothalamic Grafts and Neuroendocrine Cascade Theories of Aging

Immunocytochemical Viability of Preoptic Hypothalamic Transplants from Fetal to Reproductively Senescent Female Rats
  • Joseph Rogers
  • Gloria E. Hoffman
  • Steven F. Zornetzer
  • Wylie W. Vale


Transplantation of fetal brain tissue has been reported for several structures including the cortex,1 supraoptic and paraventricular hypothalamic nuclei,2 and substantia nigra.3 We report here transplantation of another brain structure, the preoptic area of the hypothalamus (POA), from 17- to 19-day prenatal rats to reproductively senescent female rats, aged 15–17 months. On the basis of luteinizing hormone-releasing hormone (LHRH) immunocytochemistry initiated 9 weeks after transplantation, grafted POA appear to have survived and to exhibit LHRH-positive cell bodies and fibers both afferent to and efferent from the host.


Estrous Cycle Ependymal Cell Frontal Section Estrous Cycling Paraventricular Hypothalamic Nucleus 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Joseph Rogers
    • 1
  • Gloria E. Hoffman
    • 2
  • Steven F. Zornetzer
    • 3
  • Wylie W. Vale
    • 4
  1. 1.Department of NeurologyUniversity of Massachusetts Medical SchoolWorcesterUSA
  2. 2.Department of AnatomyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  3. 3.Department of PharmacologyUniversity of CaliforniaIrvineUSA
  4. 4.Peptide Biology LaboratoryThe Salk InstituteLa JollaUSA

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