Transplantation Strategies in Spinal Cord Regeneration

  • Howard Nornes
  • Anders Björklund
  • Ulf Stenevi


Transplantation models in the brain have proven successful under conditions in which transplants serve as a “bridge” for the regeneration of axons across a site of injury, or as “release” or “driving” units to replace missing inputs to a particular target area.1–8 Similar models have been applied to the mammalian spinal cord including: (1) intraspinal transplants to form a bridge for the regeneration of spinal cord axons, (2) extraspinal transplants with only the end or ends of the transplants inserted into the cord to bypass the region of injury, and (3) intraspinal neural implants to replace missing supraspinal inputs. These models demonstrate that neurons of the spinal cord possess the ability to regenerate axons several millimeters into both intrinsic and extrinsic transplants; however, the growth of these axons into the tissue of the host spinal cord has been limited. By contrast, embryonic CNS neurons transplanted into the adult spinal cord, possess the ability to grow axons that penetrate several millimeters into spinal cord tissue. This review provides an overview of the attempts to promote regeneration of spinal cord connections by using various transplantation paradigms.


Spinal Cord Sciatic Nerve Spinal Cord Tissue Spinal Cord Transection Spinal Cord Regeneration 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Howard Nornes
    • 1
  • Anders Björklund
    • 2
  • Ulf Stenevi
    • 2
  1. 1.Department of AnatomyColorado State UniversityFort CollinsUSA
  2. 2.Departments of Histology and OphthalmologyUniversity of LundLundSweden

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