Transplantation of Catecholamine-Containing Tissues to Restore the Functional Capacity of the Damaged Nigrostriatal System

  • William J. Freed
  • Barry J. Hoffer
  • Lars Olson
  • Richard Jed Wyatt


One of the ultimate goals of neurobiological research is to develop methods of reconstituting functional capacity following damage to the CNS. Most past efforts have approached this problem with attempts to enhance the function of the remaining, undamaged tissues by providing tropic influences or cellular “drive.”1 Drugs, chemical factors, or behavioral and electrical stimulation have been used. Such treatments might potentially stimulate the functional activity of spared tissues or increase the regrowth of fiber tracts.2, 3 For example, there have been encouraging results in reversing the effects of striatal lesions with the intracerebral administration of nerve growth factor.4


Substantia Nigra Lateral Ventricle Adrenal Medulla Rotational Behavior Nigrostriatal System 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • William J. Freed
    • 1
    • 2
  • Barry J. Hoffer
    • 3
  • Lars Olson
    • 4
  • Richard Jed Wyatt
    • 1
    • 2
  1. 1.Preclinical Neurosciences SectionAdult Psychiatry BranchUSA
  2. 2.National Institute of Mental HealthSaint Elizabeths HospitalUSA
  3. 3.Department of PharmacologyUniversity of Colorado Medical CenterDenverUSA
  4. 4.Department of HistologyKarolinska InstituteStockholmSweden

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