Use of CNS Implants to Promote Regeneration of Central Axons across Denervating Lesions in the Adult Rat Brain

  • Ulf Stenevi
  • Anders Björklund
  • Lawrence F. Kromer

Abstract

Following lesions that cause substantial tissue damage, such as spinal cord transection or large hemorrhagic necroses in the brain, mammals exhibit very little evidence of regeneration of the severed axons across the necrosis (see Refs. 1–4 for reviews). This holds true also for those nonmyelinated or finely myelinated systems, such as the monoaminergic and cholinergic neurons, that have been shown to possess a very pronounced regenerative capacity (see Ref. 5 for review). Early this century, Tello6, 7 and Ramón y Cajal8 described this regenerative failure as due to a lack of neurotropic mechanisms and growth pathways in the adult mammalian CNS. Based on this notion, these authors were the first to attempt to promote regeneration of lesioned central axons by using implants of peripheral nerve.

Keywords

Sugar Formaldehyde Tyrosine Serotonin Proline 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Ulf Stenevi
    • 1
  • Anders Björklund
    • 1
  • Lawrence F. Kromer
    • 2
  1. 1.Departments of Histology and OphthalmologyUniversity of LundLundSweden
  2. 2.Department of Anatomy and Neurobiology, College of MedicineUniversity of VermontBurlingtonUSA

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