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Specificity of Termination Fields Formed in the Developing Hippocampus by Fibers from Transplants

  • Carl W. Cotman

Abstract

One of the major unsolved problems in neurobiology is understanding the mechanisms specifying the development of specific synapses and their plasticity after injury. A variety of mechanisms have been postulated to account for the development and plasticity of specific connections between central neurons, i. e., mechanical or contact guidance, chemotaxis, afferent competition, temporal matching, chemospecificity, etc. Transplantation provides a means for evaluating the potential role of at least some of these mechanisms. It is relatively simple, for example, to vary the position of the afferent source and alter the temporal sequence of events during the development of a specific afferent projection. Experiments varying such parameters have proven instrumental in analyzing the mechanism of synapse formation in nonmammalian species such as the retinotectal field in amphibians.

Keywords

Dentate Gyrus Entorhinal Cortex Molecular Layer Hippocampal Formation Terminal Field 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Carl W. Cotman
    • 1
  1. 1.Department of PsychobiologyUniversity of CaliforniaIrvineUSA

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