The Use of Fetal Hypothalamic Transplants in Developmental Neuroendocrinology

  • Charles M. Paden
  • Ann-Judith Silverman
  • Ulf Stenevi
  • Bruce S. McEwen


Developmental neuroendocrinology is a two-way street. We wish to know not only how the hypothalamic—pituitary complex comes to govern the activity of the endocrine glands, but also to understand the roles endocrine secretions may play in neural development. The introduction of techniques that permit isolated pieces of embryonic brain to survive, grow, and differentiate following transplantation into adult host brains has provided a powerful new approach to these problems. We have been transplanting embryonic rat hypothalamus and preoptic area onto the choroidal pia of adult hosts in order to study the influence of hormones on differentiation of these areas and their acquisition of neuroendocrine function. In addition, we have begun to explore the ability of fetal hypothalamic transplants to modify the neuroendocrine physiology and behavior of the adult recipients.


Sexual Differentiation Preoptic Area Gonadal Steroid Neuroendocrine Function Estradiol Benzoate 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Charles M. Paden
    • 1
  • Ann-Judith Silverman
    • 2
  • Ulf Stenevi
    • 3
  • Bruce S. McEwen
    • 4
  1. 1.Department of BiologyMontana State UniversityBozemanUSA
  2. 2.Department of Anatomy, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.Departments of Histology and OpthalmologyUniversity of LundLundSweden
  4. 4.Laboratory of NeuroendocrinologyThe Rockefeller UniversityNew YorkUSA

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