Morphological and Functional Properties of Transplanted Vasopressin Neurons
Three basic principles in neural transplantation have been demonstrated by studies conducted since 1970. Building on the earlier experiments of Dunn,1 May,2 and Le Gros Clark,3 a number of investigators4–8 have shown that fetal CNS neurons survive and develop anatomically normal features in the host brain. Lund and Hauschka9 provided some of the first evidence that grafted neural tissue becomes structurally integrated with the parenchyma of the host nervous system by demonstrating that fiber projections are established between the host and the donor. An extensive literature now exists to support this concept that grafted neurons readily send efferent fibers into the host brain and in turn receive afferents from host neurons (see Chapter 4). Finally, the ability of transplanted neurons to synthesize and release neurohormones and neurotransmitters in an appropriate manner to effect host behavior has been documented in at least three different model systems.10–14 Thus, the principles of (1) graft viability, (2) structural integration, and (3) appropriate function have been described. At issue now is the precise definition of the limits and important variables of transplant development and function.
KeywordsMedian Eminence Suprachiasmatic Nucleus Pituitary Stalk Vasopressin Release Magnocellular Neuron
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