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Bone Marrow Transplantation for Neoplasia in Man

  • Alexander Fefer
  • Martin A. Cheever
  • Philip D. Greenberg
  • C. Dean Buckner
  • Rainer Storb
  • E. Donnall Thomas

Abstract

Bone marrow transplantation (BMT) is being used with increasing frequency and increasing success for a variety of conditions in man. Although this review presents the clinical results and problems, it must be emphasized that application of BMT to man has been largely based on principles derived from studies in animal models, especially rodents and dogs (Fefer, 1974; Thomas et al., 1975). Studies in animals predicted many of the problems eventually encountered in man. The studies highlighted the importance of the major histocompatibility complex, total body irradiation (TBI), and graft-versus-host disease (GVHD) and approaches to its management. They also provided the promise of a potential graft-versus-leukemia (GVL) effect. After a few attempts at BMT in man in the 1950s and a subsequent hiatus of ten years, there was a resurgence of interest and activity in clinical BMT. This is attributable to advances in our knowledge of human histocompatibility typing, immunosuppression, and the supportive care of the immunocompromised patient.

Keywords

Bone Marrow Transplantation Marrow Transplantation Acute Leukemia Total Body Irradiation Acute GVHD 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Appelbaum, F. R., Herzig, G. P., Ziegler, J. L., Graw, R. G., Levine, A. S., and Deisseroth, A. B., 1978, Successful engraftment of cryopreserved autologous bone marrow in patients with malignant lymphoma, Blood 52:85–95.PubMedGoogle Scholar
  2. Appelbaum, F. R., Fefer, A., Cheever, M. A., Sanders, J. E., Singer, J. W., Adamson, J. W., Mickelson, E. M., Hansen, J. A., Greenberg, P. D., and Thomas E. D., 1980, Treatment of aplastic anemia by bone marrow transplantation in identical twins, Blood 55:1033–1039.PubMedGoogle Scholar
  3. Appelbaum, F. R., Fefer, A., Cheever, M. A., Buckner, C. D., Greenberg, P. D., Kaplan, H. G., Storb, R., and Thomas E. D., 1981, Treatment of non-Hodgkin’s lymphoma with marrow transplantation in identical twins, Blood 58:509–513.PubMedGoogle Scholar
  4. Appelbaum, F. R., Cheever, M. A., Fefer, A., Greenberg, P. D., Glucksberg, H., Buckner, C. D., and Thomas, E. D., 1982a, A prospective study of the value of maintenance therapy or bone marrow transplantation (BMT) in adult acute nonlymphoblastic leukemia (ANL), Blood 60:163a, No. 581.Google Scholar
  5. Appelbaum, F. R., Meyers, J. D., Fefer, A., Flournoy, N., Cheever, M. A., Greenberg, P. D., Hackman, R., and Thomas, E. D., 1982b, Nonbacterial nonfungal pneumonia following marrow transplantation in 100 identical twins, Transplantation 33:265–268.CrossRefGoogle Scholar
  6. Appelbaum, F. R., Thomas, E. D., Buckner, C. D., Clift, R. A., Deeg, H. J., Fefer, A., Neiman, P. E., Sanders, J., Stewart, P., Storb, R., and Sullivan, K., 1983, Treatment of non-Hodgkin’s lymphoma with chemoradiotherapy and allogeneic marrow transplantation, Hemato J. Oncol 1:149–157.CrossRefGoogle Scholar
  7. Atkinson, K., Storb, R., Prentice, R. L., Weiden, P. L., Witherspoon, R. P., Sullivan, K., Noel, D., and Thomas, E. D., 1979, Analysis of late infections in 89 long-term survivors of bone marrow transplantation, Blood 53:720–731.PubMedGoogle Scholar
  8. Atkinson, K., Farewell, V., Storb, R., Tsoi, M.-S., Sullivan, K. M., Witherspoon, R. P., Fefer, A., Clift, R., Goodell, B., and Thomas, E. D., 1982a, Analysis of late infections after human bone marrow transplantation: Role of genotypic nonidentity between marrow donor and recipient and of nonspecific suppressor cells in patients with chronic graft-versus-host disease, Blood 60:714–720.PubMedGoogle Scholar
  9. Atkinson, K., Hansen, J. A., Storb, R., Goehle, S., Goldstein, G., and Thomas, E. D., 1982b, T-cell subpopulations identified by monoclonal antibodies after human marrow transplantation. I. Helper-inducer and cytotoxic-suppressor subsets, Blood 59:1292–1298.PubMedGoogle Scholar
  10. Bach, F. H., and Van Rood, J. J., 1976, The major histocompatibility complex—Genetics and biology, N. Engl. J. Med. 295:806–813, 872–878, 927–936.PubMedCrossRefGoogle Scholar
  11. Baum, E., Nachman, J., Ramsay, N., Weetman, B., Neerhout, R., Littman, P., Griffin, T., Norris, D., and Sather, H., 1983, Prolonged second remissions in childhood acute lymphocytic leukemia: A report from the Childrens Cancer Study Group, Med. Pediatr. Oncol. 11:1–7.PubMedCrossRefGoogle Scholar
  12. Bensinger, W. I., Baker, D. A., Buckner, C. D., Clift, R. A., and Thomas, E. D., 1981, Immunoadsorption for removal of A and B blood-group antibodies, N. Engl. J. Med. 304:160–162.PubMedCrossRefGoogle Scholar
  13. Beutler, E., McMillan, R., and Spruce, W., 1982, The role of bone marrow transplantation in the treatment of acute leukemia in remission, Blood 59:1115–1117.PubMedGoogle Scholar
  14. Blume, K. G., Beutler, E., Bross, K. J., Chillar, R. K., Ellington, O. B., Fahey, J. L., Farbstein, M. J., Forman, S. J., Schmidt, G. M., Scott, E. P., Spruce, W. E., Turner, M. A., and Wolf, J. L., 1980, Bone-marrow ablation and allogeneic marrow transplantation in acute leukemia, N. Engl. J. Med. 302:1041–1046.PubMedCrossRefGoogle Scholar
  15. Borel, J. F., Feurer, C., Magnee, C., and Stahelin, H., 1977, Effects of the new anti-lymphocytic peptide cyclosporin A in animals, Immunology 32:1017–1025.PubMedGoogle Scholar
  16. Buckner, C. D., Rudolph, R. H., Fefer, A., Clift, R. A., Epstein, R. B., Funk, D. D., Neiman, P. E., Slichter, S. J., Storb, R., and Thomas, E. D., 1972, High-dose cyclophosphamide therapy for malignant disease. Toxicity, tumor response, and the effects of stored autologous marrow, Cancer 29:357–365.CrossRefGoogle Scholar
  17. Buckner, C. D., Stewart, P., Clift, R. A., Fefer, A., Neiman, P. E., Singer, J., Storb, R., and Thomas, E. D., 1978a, Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow, Exp. Hematol. 6:96–109.PubMedGoogle Scholar
  18. Buckner, C. D., Clift, R. A., Sanders, J. E., Meyers, J. D., Counts, G. W., Farwell, V. T., Thomas, E. D., and the Seattle Marrow Transplant Team, 1978b, Protective environment for marrow transplantation recipients. A prospective study, Ann. Int. Med. 89:893–901.PubMedGoogle Scholar
  19. Buckner, C. D., Clift, R. A., Sanders, J. E., Williams, B., Gray, M., Storb, R., and Thomas, E. D., 1978c, ABO-incompatible marrow transplants, Transplantation 26:233–238.PubMedCrossRefGoogle Scholar
  20. Buckner, C. D., Clift, R. A., Thomas, E. D., Sanders, J. E., Stewart, P. S., Storb, R., Sullivan, K. M., and Hackman, R., 1982, Allogeneic marrow transplantation for acute non-lymphoblastic leukemia in relapse using fractionated total body irradiation, Leukemia Res. 6:389–394.CrossRefGoogle Scholar
  21. Buckner, C. D., Stewart, P. S., Bensinger, W., Clift, R., Appelbaum, F., Martin, P., Sanders, J., Fefer, A., Lum, L., Storb, R., Hill, R., and Thomas, E. D., 1983, Critical issues in autologous marrow transplantation for hematologic malignancies, in: Recent Advances in Bone Marrow Transplantation (R. P. Gale, ed.), Alan R. Liss, New York, pp. 599–614.Google Scholar
  22. Camitta, B. M., Storb, R., and Thomas, E. D., 1982, Aplastic anemia. Pathogenesis, diagnosis, treatment and prognosis, N. Engl. J. Med. 306:645–652, 712–718.PubMedCrossRefGoogle Scholar
  23. Champlin, R., Ho, W., Arenson, E., and Gale, R. P., 1982, Allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic or accelerated phase, Blood 60:1038–1041.PubMedGoogle Scholar
  24. Champlin, R., Zighelboim, J., Ho, W., Feig, S., Boccia, R., Gale, R. P., and Winston, D., 1983, Treatment of acute myelogenous leukemia (AML)—Bone marrow transplantation (BMT) versus consolidation chemotherapy, Proc. Am. Soc. Clin. Oncol. 2:180a, No. C-701.Google Scholar
  25. Cheever, M. A., Fefer, A., Greenberg, P. D., Appelbaum, F. R., Armitage, J. O., Buckner, C. D., Sale, G. E., Storb, R., Witherspoon, R. P., and Thomas, E. D., 1982, Treatment of hairy-cell leukemia with chemoradiotherapy and identical-twin bone-marrow transplantation, N. Engl. J. Med. 307:479–481.PubMedCrossRefGoogle Scholar
  26. Clift, R. A., Sanders, J. E., Thomas, E. D., Williams, B., and Buckner, C. D., 1978, Granulocyte transfusions for the prevention of infection in patients receiving bone-marrow transplants, N. Engl. J. Med. 298:1052–1057.PubMedCrossRefGoogle Scholar
  27. Clift, R. A., Hansen, J. A., Thomas, E. D., Buckner, C. D., Sanders, J. E., Mickelson, E. M., Storb, R., Johnson, F. L., Singer, J. W., and Goodell, B. W., 1979, Marrow transplantation from donors other than HLA-identical siblings, Transplantation 28:235–242.PubMedCrossRefGoogle Scholar
  28. Clift, R. A., Hansen, J. A., and Thomas, E. D., 1981, The role of HLA in marrow transplantation, Transplant. Proc. 13:234–236.PubMedGoogle Scholar
  29. Clift, R. A., Buckner, C. D., Thomas, E. D., Doney, K., Fefer, A., Neiman, P. E., Singer, J., Sanders, J., Stewart, P., Sullivan, K. M., Deeg, J., and Storb, R., 1982, The treatment of chronic granulocytic leukemia in chronic phase by allogeneic marrow transplantation, Lancet 2:621–624.PubMedCrossRefGoogle Scholar
  30. Coccia, P. F., Strandjord, S. E., Gordon, E. M., Novak, L. J., Shina, D. C., Lazarus, H. M., and Herzig, R. H., 1983, High dose cytosine arabinoside (ARA-C) and fractionated total body irradiation (F-TBI) as preparation for bone marrow transplantation (BMT) for childhood acute leukemia in remission—A preliminary report, Proc. Am. Soc. Clin. Oncol. 2:175a, No. C-680.Google Scholar
  31. Curtis, J. E., and Messner, H. A., 1982, Bone marrow transplantation for leukemia and aplastic anemia: Management of ABO incompatibility, Can. Med. Assoc. J. 126:649–655.PubMedGoogle Scholar
  32. Deeg, H. J., Storb, R., Thomas, E. D., Kennedy, M. S., Flournoy, N., Buckner, C. D., Clift, R., Doney, K., Sale, G., Sanders, J., and Witherspoon, R., 1983, Marrow transplantation for acute nonlymphoblastic leukemia in first remission: Preliminary results of a randomized trial comparing cyclosporine and methotrexate for the prophylaxis of graft-versus-host disease, Transplant Proc. 15:1385–1388.Google Scholar
  33. Dicke, K. A., Spitzer, G., Zander, A. R., Lanzotti, V. J., Verma, D. S., Peters, L. J., Valdivieso, M., Lotzová, E., and McCredie, K. B., 1979, Autologous bone marrow transplantation in relapsed adult leukemia and solid tumors, Transplant Proc. 11:212–214.PubMedGoogle Scholar
  34. Dinsmore, R., Shank, B., Kapoor, N., Teitelbaum, H. D., Kirkpatrick, D., Clarkson, B., Miller, D. R., and O’Reilly, R. J., 1981, A randomized trial of marrow transplantation (BMT) versus chemotherapy (CT) maintenance for acute myelogenous leukemia in first remission. Preliminary results, Exp. Hematol. 9:213a.Google Scholar
  35. Dinsmore, R., Kirkpatrick, D., Flomenberg, N., Gulati, S., Kapoor, N., Shank, B., Reid, A., Groshen, S., and O’Reilly, R. J., 1983, Allogeneic bone marrow transplantation for patients with acute lymphoblastic leukemia, Blood 62:381–388.PubMedGoogle Scholar
  36. Doney, K., Buckner, C. D., Sale, G. E., Ramberg, R., Boyd, C., and Thomas, E. D., 1978, Treatment of chronic granulocytic leukemia by chemotherapy, total body irradiation and allogeneic bone marrow transplantation, Exp. Hematol. 6:738–747.PubMedGoogle Scholar
  37. Doney, K. C., Weiden, P. L., Storb, R., and Thomas, E. D., 1981, Treatment of graft-versus-host disease in human allogeneic marrow graft recipients. A randomized trial comparing anti-thymocyte globulin and corticosteroids, Am. J. Hematol. 11:1–8.PubMedCrossRefGoogle Scholar
  38. Douer, D., Champlin, R. E., Ho, W. G., Sarna, G. P., Wells, J. H., Graze, P. R., Cline, M. J., and Gale, R. P., 1981, High-dose combined-modality therapy and autologous bone marrow transplantation in resistant cancer, Am. J. Med. 71:973–976.PubMedCrossRefGoogle Scholar
  39. Elfenbein, G. J., Anderson, P. N., Humphrey, R. L., Mullins, G. M., Sensenbrenner, L. L., Wands, J. R., and Santos, G. W., 1976, Immune system reconstitution following allogeneic bone marrow transplantation in man: A multiparameter analysis, Transplant. Proc. 8:641–646.PubMedGoogle Scholar
  40. Elfenbein, G. J., Digamber, S. B., Bias, W. B., Burns, W. H., Sarai, R., Sensenbrenner, L. L., Tukschka, P. J., Zaczek, B. S., Zander, A. R., Epstein, R. B., Rowley, J. D., and Santos, G. W., 1978, Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells, Blood 52:627–636.PubMedGoogle Scholar
  41. Fass, L., Ochs, H. D., Thomas, E. D., Mickelson, E., Storb, R., and Fefer, A., 1973, Studies of immunological reactivity following syngeneic or allogeneic marrow grafts in man, Transplantation 16:630–640.PubMedCrossRefGoogle Scholar
  42. Fefer, A., 1972, Immunotherapy of cancer in mice, in: Frontiers in Radiation Therapy and Oncology, Volume 7 (J. M. Vaeth, ed.), Karger and University Park Press, Baltimore, pp. 35–49.Google Scholar
  43. Fefer, A., 1973, Treatment of a Moloney lymphoma with cyclophosphamide and H-2-incompatible spleen cells, Cancer Res. 33:641–644.PubMedGoogle Scholar
  44. Fefer, A., 1974, Tumor immunotherapy, in: Handbook of Experimental Pharmacology, Volume 38/1: Antineoplastic and Immunosuppressive Agents (A. C. Sartorelli and D. G. Johns, eds.), Springer-Verlag, New York, pp. 528–554.Google Scholar
  45. Fefer, A., 1982, Future of bone marrow transplantation in oncology, Int. J. Rad. Oncology 8:949–950.CrossRefGoogle Scholar
  46. Fefer, A., 1984, Bone marrow transplantation, in: MedicalOncology (P. Calabresi, P. S. Schein, and S. A. Rosenberg, eds.), Macmillan, New York (in press).Google Scholar
  47. Fefer, A., Einstein, A. B., Thomas, E. D., Buckner, C. D., Clift, R. A., Glucksberg, H., Neiman, P. E., and Storb, R., 1974, Bone-marrow transplantation for hematologic neoplasia in 16 patients with identical twins, N. Engl. J. Med. 290:1389–1393.PubMedCrossRefGoogle Scholar
  48. Fefer, A., Cheever, M. A., Thomas, E. D., Appelbaum, F. R., Buckner, C. D., Clift, R. A., Glucksberg, H., Greenberg, P. D., Johnson, F. L., Kaplan, H. G., Sanders, J. E., Storb, R., and Weiden, P. L., 1981, Bone marrow transplantation for refractory acute leukemia in 34 patients with identical twins, Blood 57:421–430.PubMedGoogle Scholar
  49. Fefer, A., Cheever, M. A., and Greenberg, P. D., 1982a, Overview of prospects and problems of lymphocyte transfer for cancer therapy, in: Progress in Cancer Research and Therapy, Volume 22: The Potential Role of T Cells in Cancer Therapy (A. Fefer and A. L. Goldstein, eds.), Raven Press, New York, pp. 1–6.Google Scholar
  50. Fefer, A., Greenberg, P. D., Cheever, M. A., Appelbaum, F. R., Bluming, A. Z., Storb, R., and Thomas, E. D., 1982b, Identical twin bone marrow transplantation (BMT) for multiple myeloma (MM), Blood 60:168a, No. 598.Google Scholar
  51. Fefer, A., Cheever, M. A., Greenberg, P. D., Appelbaum, F. R., Boyd, C. N., Buckner, C. D., Kaplan, H. G., Ramberg, R., Sanders, J. E., Storb, R., and Thomas, E. D., 1982c, Treatment of chronic granulocytic leukemia with chemoradiotherapy and transplantation of marrow from identical twins, N. Engl. J. Med. 306:63–68.PubMedCrossRefGoogle Scholar
  52. Fefer, A., Cheever, M. A., Greenberg, P. D., Appelbaum, F. R., Buckner, C. D., Clift, R. A., Sanders, J., Storb, R., and Thomas, E. D., 1983, Bone marrow transplantation (BMT) for acute leukemia in patients with identical twins: Improved results with BMT in complete remission (CR), Proc. Am. Soc. Clin. Oncol. 2:182a, No. C-708.Google Scholar
  53. Fialkow, P. J., Thomas, E. D., Bryant, J. I., and Neiman, P. E., 1971, Leukaemic transformation of engrafted human marrow cells in vivo, Lancet 1:251–255.PubMedCrossRefGoogle Scholar
  54. Fialkow, P. J., Jacobson, R. J., and Papayannopoulou, T., 1977, Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyteJmacrophage, Am. J. Med. 63:125–130.PubMedCrossRefGoogle Scholar
  55. Filipovich, A. H., McGlave, P. B., Ramsay, N. K. C., Goldstein, G., Warkentin, P. I., and Kersey, J. H., 1982, Pretreatment of donor bone marrow with monoclonal antibody OKT3 for prevention of acute graft-versus-host disease in allogeneic histocompatible bone-marrow transplantation, Lancet 1:1266–1269.PubMedCrossRefGoogle Scholar
  56. Forman, S. J., Spruce, W. E., Farbstein, M. J., Wolf, J. L., Scott, E. P., Nademanee, A. P., Fahey, J. L., Hecht, T., Zaia, J. A., Krance, R. A., Findley, D. O., and Blume, K. G., 1983, Bone marrow ablation followed by allogeneic marrow grafting during first remission of acute nonlymphocytic leukemia, Blood 61:439–442.PubMedGoogle Scholar
  57. Fox, R., McMillan, R., Spruce, W., Tani, P., Mason, D., and The Scripps Clinic Bone Marrow Transplantation Team, 1982, Analysis of T lymphocytes after bone marrow transplantation using monoclonal antibodies, Blood 60:578–582.PubMedGoogle Scholar
  58. Gale, R. P., 1980, Clinical trials of bone marrow transplantation in leukemia, in: Biology of Bone Marrow Transplantation (R. P. Gale and C. F. Fox, eds.), Academic Press, New York, pp. 11–27.Google Scholar
  59. Gale, R. P., for the Transplantation Biology Unit, 1981, A prospective controlled trial of bone marrow transplantation vs. chemotherapy in acute myelogenous leukemia, Blood 58:173a, No. 604.Google Scholar
  60. Gale, R. P., 1982, Progress in bone marrow transplantation in man, Surv. Immunol. Res. 1:40–66.PubMedGoogle Scholar
  61. Gale, R. P., Opelz, G., Mickey, M. R., Graze, P. R., and Saxon, A., 1978, Immunodeficiency following allogenic bone marrow transplantation, Transplant. Proc. 10:223–227.PubMedGoogle Scholar
  62. Gale, R. P., Kay, H. E. M., Rimm, A. A., and Bortin, M. M., 1982, Bone-marrow transplantation for acute leukaemia in first remission, Lancet 1:1006–1009.CrossRefGoogle Scholar
  63. Glucksberg, H., Storb, R., Fefer, A., Buckner, C. D., Neiman, P. E., Clift, R. A., Lerner, K. G., and Thomas, E. D., 1974, Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors, Transplantation 18:295–304.PubMedCrossRefGoogle Scholar
  64. Goh, K., and Klemperer, M. R., 1977, In vivo leukemic transformation: Cytogenetic evidence of in vivo leukemic transformation of engrafted marrow cells, Am. J. Hematol. 2:283–290.PubMedCrossRefGoogle Scholar
  65. Goldman, J. M., Johnson, S. A., Catovsky, D., Agnarsdottir, G., Goolden, A. W. G., and Galton, D. A. G., 1981, Identical twins marrow transplantation for patients with leukemia and lymphoma, Transplantation 31:140–141.PubMedCrossRefGoogle Scholar
  66. Goldman, J. M., McCarthy, D. M., Hows, J. M., Catovsky, K., Goolden, A. W., Baughan, A. S., Worsley, A. M., Gordon-Smith, E. C., Batchelor, J. R., and Galton, D. A., 1982, Marrow transplantation for patients in the chronic phase of chronic granulocytic leukaemia, Lancet 2:623–625.PubMedCrossRefGoogle Scholar
  67. Gossett, T. C., Gale, R. P., Fleischman, H., Austin, G. E., Sparkes, R. S., and Taylor, C. R., 1979, Immunoblastic sarcoma in donor cells after bone-marrow transplantation, N. Engl. J. Med. 300:904–907.PubMedCrossRefGoogle Scholar
  68. Gratwohl, A. A., Moutsopoulos, H. M., Chused, T. M., Akizuki, M., Wolf, R. O., Sweet, J. B., and Deisseroth, A. B., 1977, Sjögren-type syndrome after allogeneic bone-marrow transplantation, Ann. Intern. Med. 87:703–706.PubMedGoogle Scholar
  69. Graze, P. R., and Gale, R. P., 1979, Chronic graft versus host disease: A syndrome of disordered immunity, Am. J. Med. 66:611–620.PubMedCrossRefGoogle Scholar
  70. Hansen, J. A., Clift, R. A., Thomas, E. D., Buckner, C. D., Storb, R., and Giblett, E. R., 1980, Transplantation of marrow from an unrelated donor to a patient with acute leukemia, N. Engl. J. Med. 303:565–567.PubMedCrossRefGoogle Scholar
  71. Hansen, J. A., Clift, R. A., Beatty, P. G., Mickelson, E. M., Nisperos, B., Martin, P. J., and Thomas, E. D., 1983, Marrow transplantation from donors other than HLA genotypically identical siblings, in: Recent Advances in Bone Marrow Transplantation (R. P. Gale, ed.), Alan R. Liss, New York, pp. 739–756.Google Scholar
  72. Herzig, G. P., 1981, Autologous marrow transplantation in cancer therapy, Prog. Hematol. 12:1–23.PubMedGoogle Scholar
  73. Herzig, G. P., Phillips, G. L., Mill, W., Napomberjara, C., Bernard, S., and Wolff, S., 1978, Treatment of hematologic malignancy with cyclophosphamide (CY), total body irradiation (TBI) and autologous bone marrow transplantation (BMTX), Blood 52:536a.Google Scholar
  74. Herzig, R., Lazarus, H., Gross, S., Graham-Pole, J., Strandjord, S., Gordon, E., Schacter, B., Coccia, P., and Warm, S., 1982, Incidence of graft-versus-host disease (GVHD) with and without methotrexate (MTX) prophylaxis in allogeneic bone marrow transplant (BMT) patients (PTS), Blood 60:169a, No. 602.Google Scholar
  75. Hickman, R. O., Buckner, C. D., Clift, R. A., Sanders, J. E., Stewart, P., and Thomas, E. D., 1979, A modified right atrial catheter for access to the venous system in marrow transplant recipients, Surgery 148:871–875.Google Scholar
  76. Hood, A. F., Soter, N. A., Rappeport, J., and Gigli, I., 1977, Graft-versus-host reaction: Cutaneous manifestations following bone marrow transplantation, Arch. Dermatol. 113:1087–1091.PubMedCrossRefGoogle Scholar
  77. Hows, J. M., Palmer, S., and Gordon-Smith, E. C., 1982, Use of cyclosporin A in allogeneic bone marrow transplantation for severe aplastic anemia, Transplantation 33:382–386.PubMedCrossRefGoogle Scholar
  78. Johnson, F. L., Thomas, E. D., Clark, B. S., Chard, R. L., Hartmann, J. R., and Storb, R., 1981, A comparison of marrow transplantation with chemotherapy for children with acute lymphoblastic leukemia in second or subsequent remission, N. Engl. J. Med. 305:846–851.PubMedCrossRefGoogle Scholar
  79. Kaizer, H., Leventhal, B. G., Wharam, M. D., Munoz, L. L., Elfenbein, G. J., Tutschka, P. J., and Santos, G. W., 1979, Cryopreserved autologous bone marrow transplantation in the treatment of selected pediatric malignancies: A preliminary report, Transplant Proc. 11:208–211.PubMedGoogle Scholar
  80. Kersey, J. H., Ramsay, N. K. C., Kim, T., McGlave, P., Krivit, W., Levitt, S., Filipovich, A., Woods, W., O’Leary, M., Coccia, P., and Nesbit, M. E., 1982, Allogeneic bone marrow transplantation in acute nonlymphocytic leukemia: A pilot study, Blood 60:400–403.PubMedGoogle Scholar
  81. Körbling, M., Hess, A. D., Tutschka, P. J., Kaizer, J., Colvin, M. O., and Santos, G. W., 1982, 4-hydroperoxycyclophosphamide: A model for eliminating residual human tumor cells and T-lymphocytes from the bone marrow graft, Br. J. Haematol. 52:89–96.PubMedCrossRefGoogle Scholar
  82. Korngold, R., and Sprent, J., 1978, Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow, J. Exp. Med. 148:1687–1698.PubMedCrossRefGoogle Scholar
  83. Krolick, K. A., Uhr, J. W., and Vitetta, E. S., 1982, Selective killing of leukaemia cells by antibody-toxin conjugates: Implications for autologous bone marrow transplantation, Nature 295:604–605.PubMedCrossRefGoogle Scholar
  84. Lawley, T. J., Peck, G. L., Moutsopoulos, H. M., Gratwohl, A. A., and Deisseroth, A. B., 1977, Scleroderma, Sjögren-like syndrome, and chronic graft-versus-host disease, Ann. Intern. Med. 87:707–709.PubMedGoogle Scholar
  85. Lazarus, H. M., Herzig, R. H., Graham-Pole, J., Wolff, S. M., Phillips, G. L., Strandjord, S., Hurd, D., Forman, W., Gordon, E. M., Coccia, P., Gross, S., and Herzig, G. P., 1983, Intensive melphalan chemotherapy and cryopreserved autologous bone marrow transplantation for the treatment of refractory cancer, J. Clin. Oncol. 1:359–367.PubMedGoogle Scholar
  86. Lochte, H. L., Jr., Levy, A. S., Guenther, D. M., Thomas, E. D., and Ferrebee, J. W., 1962, Prevention of delayed foreign marrow reaction in lethally irradiated mice by early administration of methotrexate, Nature 196:1110–1111.PubMedCrossRefGoogle Scholar
  87. Lum, L. G., Scigneuret, M. C., Storb, R. F., Witherspoon, R. P., and Thomas, E. D., 1981, In vitro regulation of immunoglobulin synthesis after marrow transplantation. I. T-cell and B-cell deficiencies in patients with and without chronic graft-versus-host disease, Blood 58:431–439.PubMedGoogle Scholar
  88. Lum, L. G., Orcutt-Thordarson, N., Scigneuret, M. C., and Storb, R., 1982, The regulation of Ig synthesis after marrow transplantation. IV. T4 and T8 subset function in patients with chronic graft-versus-host disease, J. Immunol. 129:113–119.PubMedGoogle Scholar
  89. McGlave, P. B., Kim, T. H., Hurd, D. D., Arthur, D. C., Ramsay, N. K., and Kersey, J., 1982, Successful allogeneic bone-marrow transplantation for patients in the accelerated phase of chronic granulocytic leukaemia, Lancet 2:625–627.PubMedCrossRefGoogle Scholar
  90. Mannoni, P., Vernant, J. P., Rodet, M., Rochant, H., Bracq, C., Tournesa, A., Feuilhade, F., Bierling, P., and Dreyfus, B., 1980, Marrow transplantation for acute nonlymphoblastic leukemia in first remission, Blut 41:220–225.Google Scholar
  91. Martin, P. J., Hansen, J. A., Remlinger, K., Torok-Storb, B., Storb, R., and Thomas, E. D., 1983, Murine monoclonal anti-human T cell antibodies for the prevention and treatment of graftversus-host disease, in: Recent Advances in Bone Marrow Transplantation (R. P. Gale, ed.), Alan R. Liss, New York, pp. 313–330.Google Scholar
  92. Mauer, A. M., 1980, Therapy of acute lymphoblastic leukemia in childhood, Blood 56:1–10.PubMedGoogle Scholar
  93. Messner, H. A., Curtis, J. E., and Norman, C., 1981, Allogeneic bone marrow transplantation in patients with CML prior to blastic crisis, Blood 58:175a.Google Scholar
  94. Meyers, J. D., and Thomas, E. D., 1982, Infection complicating bone marrow transplantation, in: Clinical Approach to Infection in the Immunocompromised Host (R. H. Rubin and L. S. Young, eds.), Plenum Medical Book Company, New York, pp. 507–551.Google Scholar
  95. Meyers, J. D., Leszczynski, J., Zaia, J. A., Floumoy, N., Newton, B., Snydman, D. R., Wright, G. G., Levin, M. J., and Thomas, E. D., 1983, Prevention of cytomegalovirus infection by cytomegalovirus immune globulin after marrow transplantation, Ann. Intern. Med. 98:442–446.PubMedGoogle Scholar
  96. Meyers, J. D., Floumoy, N., Wade, J. C., Hackman, R. C., McDougall, J. K., Neiman, P. E., and Thomas, E. D., 1983, Biology of interstitial pneumonia after marrow transplantation, in: Recent Advances in Bone Marrow Transplantation (R. P. Gale, ed.), Alan R. Liss, New York, pp. 405–424.Google Scholar
  97. Morgenstern, G. R., 1980, Allogeneic bone marrow transplantation for acute leukaemia. Experience in 55 patients, Blut 41:213–215.Google Scholar
  98. Müller-Ruchholtz, W., Wottge, H.-U., and Müller-Hermelink, H. K., 1976, Bone marrow transplantation in rats across strong histocompatibility barriers by selective elimination of lymphoid cells in donor marrow, Transplant. Proc. 8:537–541.PubMedGoogle Scholar
  99. Neiman, P. E., Reeves, W., Ray, G., Floumoy, N., Lemer, K. G., Sale, G. E., and Thomas, E. D., 1977, A prospective analysis of interstitial pneumonia and opportunistic viral infection among recipients of allogeneic bone marrow grafts, J. Infect. Dis. 136:754–767.PubMedCrossRefGoogle Scholar
  100. Newburger, P. E., Latt, S. A., Pesando, J. M., Gustashaw, K., Powers, M., Chaganti, R. S. K., and O’Reilly, R. J., 1981, Leukemia relapse in donor cells after allogeneic bone-marrow transplantation, N. Engl. J. Med. 304:712–714.PubMedCrossRefGoogle Scholar
  101. Noel, D. R., Witherspoon, R. P., Storb, R., Atkinson, K., Doney, K., Mickelson, E. M., Ochs, H. D., Warren, R. P., Weiden, P. L., and Thomas, E. D., 1978, Does graft-versus-host disease influence the tempo of immunologic recovery after allogeneic human marrow transplantation? An observation of 56 long-term survivors, Blood 51:1087–1105.PubMedGoogle Scholar
  102. Ochs, H. D., Lum, L. G., Johnson, F. L., Schiffman, G., Wedgwood, R. J., and Storb, R., 1982, Bone marrow transplantation in the Wiskott-Aldrich syndrome: Complete hematologic and immunologic reconstitution, Transplantation 34:284–288.PubMedCrossRefGoogle Scholar
  103. O’Reilly, R. J., Riech, L., Gold, J., Kirkpatrick, D., Dinsmore, R., Kapoor, N., and Condie, R., 1984, A randomized trial of intravenous hyperimmune globulin for the prevention of cytomegalovirus (CMV) infections following marrow transplantation: Preliminary results, Transplant. Proc. (in press).Google Scholar
  104. Osserman, E. F., DiRe, L. B., DiRe, J., Sherman, W. H., Hersman, J. A., and Storb, R., 1982, Identical twin marrow transplantation in multiple myeloma, Acta Haematol. 68:215–223.PubMedCrossRefGoogle Scholar
  105. Pahwa, R., Pahwa, S., O’Reilly, R., and Good, R. A., 1978, Treatment of the immunodeficiency diseases—Progress toward replacement therapy emphasizing cellular and macromolecular engineering, Springer Semin. Immunopathol. 1:355–404.Google Scholar
  106. Peterson, B. A., and Bloomfield, C. D., 1981, Long-term disease-free survival in acute non-lymphocytic leukemia, Blood 57:1144–1147.PubMedGoogle Scholar
  107. Phillips, G. L., 1983, Current clinical trials with intensive therapy and autologous bone marrow transplantation (ABMT) for lymphomas and solid tumors, in: Recent Advances in Bone Marrow Transplantation (R. P. Gale, ed.), Alan R. Liss, New York, pp. 567–598.Google Scholar
  108. Powles, R. L., Barrett, A. J., Clink, H. M., Kay, H. E., Sloane, J., and McElwain, M. J., 1978, Cyclosporin A for the treatment of graft-versus-hose disease in man, Lancet 2:1327–1331.PubMedCrossRefGoogle Scholar
  109. Powles, R. L., Clink, H. M., Spence, D., Morgenstern, G., Watson, J. G., Selby, P. J., Woods, M., Barrett, A., Jameson, B., Sloane, J., Lawler, S. D., Kay, H. E. M., Lowson, D., McElwain, T. J., and Alexander, P., 1980a, Cyclosporin A to prevent graft-versus-host disease in man after allogeneic bone-marrow transplantation, Lancet 1:327–329.PubMedCrossRefGoogle Scholar
  110. Powles, R. L., Morgenstern, G., Clink, H. M., Hedley, D., Bandini, G., Lumley, H., Watson, J. G., Lawson, D., Spence, D., Barrett, A., Jameson, B., Lawler, S., Kay, H. E. M., and McElwain, T. J., 1980b, The place of bone-marrow transplantation in acute myelogenous leukaemia, Lancet 1:1047–1050.PubMedCrossRefGoogle Scholar
  111. Powles, R. L., Morgenstern, G. R., Kay, H. E. M., McElwain, T. J., Clink, H. M., Dady, P. J., Barrett, A., Jameson, B., Depledge, M. H., Watson, J. G., Sloane, J., Leigh, M., Lumley, H., Hedley, D., Lawler, S. D., Filshie, J., and Robinson, B., 1983, Mismatched family donors for bone-marrow transplantation as treatment for acute leukaemia, Lancet 1:612–615.PubMedCrossRefGoogle Scholar
  112. Prentice, H. G., Blacklock, H. A., Janossy, G., Bradstock, K. F., Skeggs, D., Goldstein, G., and Hoffbrand, A. V., 1982, Use of anti-T-cell monoclonal antibody OKT3 to prevent acute graft-versus-host disease in allogeneic bone-marrow transplantation for acute leukaemia, Lancet 1:700–703.PubMedCrossRefGoogle Scholar
  113. Rai, K. R., Holland, J. F., Glidewell, O. J., Wienberg, V., Brunner, K., Obrecht, J. P., Preisler, H. D., Nawabi, I. W., Prager, D., Carey, R. W., Cooper, M. R., Haurani, F., Hutchison, J. L., Silver, R. T., Falkson, G., Wiernik, P., Hoagland, H. C., Bloomfield, C. D., James, G. W., Gottlieb, A., Ramanan, S. V., Blom, J., Nissen, N. I., Bank, A., Ellison, R. R., Kung, F., Henry, P., McIntyre, O. R., and Kaan S. K., 1981, Treatment of acute myelocytic leukemia: A study by cancer and leukemia group B, Blood 58:1203–1212.PubMedGoogle Scholar
  114. Ramsay, N. K. C., Kersey, J. H., Robison, L. L., McGlave, P. B., Woods, W. G., Krivit, W., Kim, T. H., Goldman, A. I., and Nesbit, M. E., Jr., 1982, A randomized study of the prevention of acute graft-versus-host disease, N. Engl. J. Med. 306:392–397.PubMedCrossRefGoogle Scholar
  115. Reinherz, E. L., Parkman, R., Rappeport, J., Rosen, F. S., and Schlossman, S. F., 1979, Aberrations of suppressor T cells in human graft-versus-host disease, N. Engl. J. Med. 300:1061–1068.PubMedCrossRefGoogle Scholar
  116. Reisner, Y., Kapoor, N., Kirkpatrick, D., Pollack, M. S., Cunningham-Rundles, S., Dupont, B., Hodes, M. Z., Good, R. A., and O’Reilly, R., 1983, Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells, Blood 61:341–348.PubMedGoogle Scholar
  117. Ringdén, O., Lönnqvist, B., Lundgren, G., Gahrton, G., Groth, C., Möller, E., Bâryd, L, Johansson, B., Pihlstedt, P., and Gullbring, B., 1982, Experience with a cooperative bone marrow transplantation program in Stockholm, Transplantation 33:500–504.PubMedCrossRefGoogle Scholar
  118. Ritz, J., Sallan, S. E., Bast, R. C., Jr., Lipton, J. M., Clavell, L. A., Feeney, M., Hercend, T., Nathan, D. G., and Schlossman, S. F., 1982, Autologous bone-marrow transplantation in CALLA-positive acute lymphoblastic leukaemia after in vitro treatment with J5 monoclonal antibody and complement, Lancet 2:60–63.PubMedCrossRefGoogle Scholar
  119. Rodt, H., Thierfelder, S., and Eulitz, M., 1974, Anti-lymphocytic antibodies and marrow transplantation. III. Effect of heterologous anti-brain antibodies on acute secondary disease in mice, Eur. J. Immunol. 4:25–29.CrossRefGoogle Scholar
  120. Rodt, H., Kolb, H. J., Netzel, B., Haas, R. J., Wilms, K., Gotze, Ch. B., Link, H., Thierfelder, S., and the Munich Cooperative Group of BMT, 1981, Effect of anti-T-cell globulin on GVHD in leukemic patients treated with BMT, Transplant. Proc. 13:257–261.PubMedGoogle Scholar
  121. Sale, G. E., Lerner, K. G., Barker, E. A., Shulman, H. M., and Thomas, E. D., 1977, The skin biopsy in the diagnosis of acute graft-versus-host disease in man, Am. J. Pathol. 89:621–633.PubMedGoogle Scholar
  122. Sallan, S. E., and Hitchcock-Bryan, S., 1981, Relapse in childhood acute lymphoblastic leukemia after elective cessation of initial treatment: Failure of subsequent treatment with cyclophosphamide, cytosine arabinoside, vincristine and prednisone (COAP), Med. Pediatr. Oncol. 9:455–462.PubMedCrossRefGoogle Scholar
  123. Sanders, J. E., Hickman, R. O., Aker, S., Hersman, J., Buckner, C. D., and Thomas, E. D., 1982, Experience with double lumen right atrial catheters, J. Parenteral Enteral Nutr. 6:95–99.CrossRefGoogle Scholar
  124. Santos, G. W., Sensenbrenner, L. L., Burke, P. J., Mullins, G. M., Anderson, P. N., Tutschka, P. J, Braine, H. G., Davis, T. E., Humphrey, R. L., Abeloff, M. D., Bias, W. B., Borgaonkar, D. S., and Slavin, R. E., 1974, Allogeneic marrow grafts in man using cyclophosphamide, Transplant. Proc. 6:345–348.PubMedGoogle Scholar
  125. Santos, G. W., Tutschka, P. J., Beschomer, W. E., Burns, W. H., Bias, W. B., Elfenbein, G. J., Kaizer, H., Sarai, R., Sensenbrenner, L. L., and Stuart, R. K., 1981a, Marrow transplantation in acute non-lymphocytic leukemia (ANL) following busulfan (BU) and cyclophosphamide (CY), Blood 58:176a.Google Scholar
  126. Santos, G. W., Bias, W., Burns, W., Elfenbein, G., Kaizer, H., Sarai, R., Sensenbrenner, L., Stuart, R., and Tutschka, P., 1981b, Syngeneic bone marrow transplantation, Baltimore experience, Exp. Hematol. 9:141a, No. 243.Google Scholar
  127. Sarna, G., Feig, S., Opelz, G., Young, L., Langdon, E., Juillard, G., Naiem, F., Sparkes, R., Golde, D., Territo, M., Haskell, C. M., Smith, G., Fawzi, F., Falk, P., Fahey, J., Cline, M., and Gale, R. P., 1977, Bone marrow transplantation with intensive combination chemotherapyJradiation therapy (SCARI) in acute leukemia, Ann. Intern. Med. 86:155–161.Google Scholar
  128. Saurai, J. H., Didier-Jean, L., Gluckman, E., and Bussel, A., 1975, Graft versus host reaction and lichen planus-like eruption in man, Br. J. Dermatol. 92:591–592.CrossRefGoogle Scholar
  129. Schubach, W. H., Hackman, R., Neiman, P. E., Miller, G., and Thomas, E. D., 1982, A monoclonal immunoblastic sarcoma in donor cells bearing Epstein-Barr virus genomes following allogeneic grafting for acute lymphoblastic leukemia, Blood 60:180–187.PubMedGoogle Scholar
  130. Shulman, H. M., Sale, G. E., Lerner, K. G., Barker, E. A., Weiden, P. L., Sullivan, K., Gallucci, B., Thomas, E. D., and Storb, R., 1978, Chronic cutaneous graft-versus-host disease in man, Am. J. Pathol. 91:545–564.PubMedGoogle Scholar
  131. Shulman, H. M., McDonald, G. B., Matthews, D., Doney, K. C., Kopecky, K. J., Gauvreau, J. M., and Thomas, E. D., 1980a, An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation, Gastroenterology 79:1178–1191.PubMedGoogle Scholar
  132. Shulman, H. M., Sullivan, K. M., Weiden, P. L., McDonald, G. B., Striker, G. E., Sale, G. E., Hackman, R., Tsoi, M. S., Storb, R., and Thomas, E. D., 1980b, Chronic graft-versus-host syndrome in man: A long-term clinicopathologic study of 20 Seattle patients, Am. J. Med. 69:204–217.PubMedCrossRefGoogle Scholar
  133. Simes, M. A., Johansson, E., and Rapola, J., 1977, Scleroderma-like graft-versus-host disease as late consequence of bone-marrow grafting, Lancet 2:831–832.CrossRefGoogle Scholar
  134. Sokal, J. E., 1976, Evaluation of survival data for chronic myelocytic leukemia, Am. J. Hematol. 1:493–500.PubMedCrossRefGoogle Scholar
  135. Sosa, R., Weiden, P. L., Storb, R., Syrotuck, J., and Thomas, E. D., 1980, Granulocyte function in human allogeneic marrow graft recipients, Exp. Hematol. 8:1183–1189.PubMedGoogle Scholar
  136. Speck, B., Gratwohl, A., Nissen, C., Osterwalder, B., Muller, M., Burry, H. P., Signer, E., and Jeannet, M., 1981, Further experience with cyclosporin-A in allogeneic bone marrow transplantation, Exp. Hematol. 9:124a, No. 211.Google Scholar
  137. Speck, B., Gratwohl, A., Nissen, C., Osterwalder, B., Muller, M., Bannert, P., Muller, H., and Jeannet, M., 1982, Allogeneic marrow transplantation for chronic granulocytic leukemia, Blut 45:237–242.PubMedCrossRefGoogle Scholar
  138. Stewart, P. S., 1982, Autologous bone marrow transplantation in metastatic breast cancer, Breast Cancer Res. Treat. 2:85–92.PubMedCrossRefGoogle Scholar
  139. Stewart, P., Buckner, C. D., Thomas, E. D., Bagley, C., Bensinger, W., Clift, R. A., Appelbaum, F. R., and Sanders, J., 1984, Intensive chemoradiotherapy with autologous marrow transplantation for small cell carcinoma of the lung, Cancer Treat. Rep. (in press).Google Scholar
  140. Storb, R., and Thomas, E. D., 1984, Current state of marrow transplantation, in: Contemporary Hematology/Oncology, Volume 3 (R. Silber, A. S. Gordon, and J. LoBue, eds.), New York, Plenum Medical Book Company, pp. 235–266.Google Scholar
  141. Storb, R., Epstein, R. B., Graham, T. C., and Thomas, E. D., 1970, Methotrexate regimens for control of graft-versus-host disease in dogs with allogeneic marrow grafts, Transplantation 9:240–246.PubMedCrossRefGoogle Scholar
  142. Storb, R., Gluckman, E., Thomas, E. D., Buckner, C. D., Clift, R. A., Fefer, A., Glucksberg, H., Graham, T. C., Johnson, F. L., Lemer, K. G., Neiman, P. E., and Ochs, H., 1974, Treatment of established human graft-versus-host disease by antithymocyte globulin, Blood 44:57–75.Google Scholar
  143. Storb, R., Thomas, E. D., Buckner, C. D., Clift, R. A., Deeg, H. J., Fefer, A., Goodell, B. W., Sale, G. E., Sanders, J. E., Singer, J., Stewart, P., and Weiden, P. L., 1980a, Marrow transplantation in thirty “untransfused” patients with severe aplastic anemia, Ann. Intern. Med. 92:30–36.PubMedGoogle Scholar
  144. Storb, R., Weiden, P. L., Deeg, H. J., Torok-Storb, B., Atkinson, K., Graham, T. C., and Thomas, E. D., 1980b, Marrow graft studies in dogs, in: Immunobiology of Bone Marrow Transplantation (S. Thierfelder, H. Rodt, and H. Kolb, eds.), Springer-Verlag, Heidelberg, pp. 43–52.CrossRefGoogle Scholar
  145. Storb, R., Doney, K. C., Thomas, E. D., Appelbaum, F., Buckner, C. D., Clift, R. A., Deeg, H. J., Goodell, B. W., Hackman, R., Hansen, J. A., Sanders, J., Sullivan, K., Weiden, P. L., and Witherspoon, R. P., 1982, Marrow transplantation with or without donor buffy coat cells for 65 transfused aplastic anemia patients, Blood 59:236–246.PubMedGoogle Scholar
  146. Sullivan, K. M., Shulman, H. M., Storb, R., Weiden, P. L., Witherspoon, R. P., McDonald, G. B., Schubert, M. M., Atkinson, K., and Thomas, E. D., 1981, Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression, Blood 57:267–276.PubMedGoogle Scholar
  147. Thomas, E. D., 1982, The role of marrow transplantation in the eradication of malignant disease, Cancer 49:1963–1969.PubMedCrossRefGoogle Scholar
  148. Thomas, E. D., 1983, Marrow transplantation for malignant diseases: Karnofsky memorial lecture, J. Clin. Oncol. 1:517–531.PubMedGoogle Scholar
  149. Thomas, E. D., Lochte, H. L., Jr., Cannon, J. H., Sahler, O. D., and Ferrebee, J. W., 1959, Supralethal whole body irradiation and isologous marrow transplantation in man, J. Clin. Invest. 38:1709–1716.CrossRefGoogle Scholar
  150. Thomas, E. D., Bryant, J. I., Buckner, C. D., Clift, R. A., Fefer, A., Johnson, F. L., Neiman, P., Ramberg, R. E., and Storb, R., 1972, Leukaemic transformation of engrafted human marrow cells in vivo, Lancet 1:1310–1313.PubMedCrossRefGoogle Scholar
  151. Thomas, E. D., Storb, R., Clift, R. A., Fefer, A., Johnson, F. L., Neiman, P. E., Lemer, K. G., Glucksberg, H., and Buckner, C. D., 1975, Bone-marrow transplantation, N. Engl. J. Med. 292:832–843, 895–902.PubMedCrossRefGoogle Scholar
  152. Thomas, E. D., Buckner, C. D., Banaji, M., Clift, R. A., Fefer, A., Flournoy, N., Goodell, B. W., Hickman, R. O., Lemer, K. G., Neiman, P. E., Sale, G. E., Sanders, J. E., Singer, J., Stevens, M., Storb, R., and Weiden, P. L., 1977, One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation, Blood 49:511–533.PubMedGoogle Scholar
  153. Thomas, E. D., Sanders, J. E., Flournoy, N., Johnson, F. L., Buckner, C. D., Clift, R. A., Fefer, A., Goodell, B. W., Storb, R., and Weiden, P. L., 1979a, Marrow transplantation for patients with acute lymphoblastic leukemia in remission, Blood 54:468–476.PubMedGoogle Scholar
  154. Thomas, E. D., Buckner, C. D., Clift, R. A., Fefer, A., Johnson, F. L., Neiman, P. E., Sale, G. E., Sanders, J. E., Singer, J. W., Shulman, H., Storb, R., and Weiden, P. L., 1979b, Marrow transplantation for acute nonlymphoblastic leukemia in first remission, N. Engl. J. Med. 301:597–599.PubMedCrossRefGoogle Scholar
  155. Thomas, E. D., Clift, R. A., Hersman, J., Sanders, J. E., Stewart, P., Buckner, C. D., Fefer, A., McGuffin, R., Smith, J. W., and Storb, R., 1982, Marrow transplantation for acute nonlymphoblastic leukemia in first remission using fractionated or single-dose irradiation, Int. J. Rad. OncoJ. Biol. Phys. 8:817–821.CrossRefGoogle Scholar
  156. Tsoi, M., Storb, R., Jones, E., Weiden, P. L., Shulman, H., Witherspoon, R., Atkinson, K., and Thomas, E. D., 1978, Deposition of IgM and complement at the dermoepidermal junction in acute and chronic cutaneous graft-vs-host disease in man, J. Immunol. 120:1485–1491.PubMedGoogle Scholar
  157. Tsoi, M.-S., Storb, R., Dobbs, S., Kopecky, K. J., Santos, E., Weiden, P. L., and Thomas, E. D., 1979, Nonspecific suppressor cells in patients with chronic graft-vs-host disease after marrow grafting, J. Immunol. 123:1970–1976.PubMedGoogle Scholar
  158. Tutschka, P. J., Beschomer, W. E., Hess, A. D., and Santos, G. W., 1983, Cyclosporin-A to prevent graft-versus-host disease: A pilot study in 22 patients receiving allogeneic marrow transplants, Blood 61:318–325.PubMedGoogle Scholar
  159. Weiden, P. L., Doney, K., Storb, R., and Thomas, E. D., 1978, Anti-human thymocyte globulin (ATG) for prophylaxis and treatment of graft-versus-host disease in recipients of allogeneic marrow grafts, Transplant. Proc. 10:213–216.PubMedGoogle Scholar
  160. Weiden, P. L., Flournoy, N., Thomas, E. D., Prentice, R., Fefer, A., Buckner, C. D., and Storb, R., 1979, Antileukemic effect of graft-versus-host disease in human recipients of allogeneicmarrow grafts, N. Engl. J. Med. 300:1068–1073.PubMedCrossRefGoogle Scholar
  161. Weiden, P. L., Sullivan, K. M., Flournoy, N., Storb, R., Thomas, E. D., and the Seattle Marrow Transplant Team, 1981, Antileukemic effect of chronic graft-versus-host disease. Contribution to improved survival after allogeneic marrow transplantation, N. Engl. J. Med. 304:1529–1533.PubMedCrossRefGoogle Scholar
  162. Weinstein, H. J., Mayer, R. J., Rosenthal, D. S., Camita, B. M., Coral, F. S., Nathan, D. G., and Frei, E., 1980, Treatment of acute myelogenous leukemia in children and adults, N. Engl. J. Med. 303:473–478.PubMedCrossRefGoogle Scholar
  163. Winston, D. J., Gale, R. P., Meyer, D. V., Young, L. S., and the UCLA Bone Marrow Transplantation Group, 1979, Infectious complications of human bone marrow transplantation, Medicine 58:1–31.PubMedCrossRefGoogle Scholar
  164. Winston, D. J., Ho, W. G., Howell, C. L., Miller, M. J., Mickey, M. R., Martin, W. J., Lin, C. H., and Gale, R. P., 1980a, Cytomegalovirus infections associated with leukocyte transfusions, Ann. Intern. Med. 93:671–675.PubMedGoogle Scholar
  165. Winston, D. J., Bryson, Y. K., Ho, W. G., Territo, M. C., Golde, D. W., and Gale, R. P., 1980b, Interstitial pneumonia and cytomegalovirus infection after bone marrow transplantation, in: The Biology of Bone Marrow Transplantation (R. P. Gale, ed.), Academic Press, New York, pp. 83–96.Google Scholar
  166. Winston, D. J., Pollard, R. B., Ho, W. G., Gallagher, J. G., Rasmussen, L. E., Huang, S. N.-Y, Lin, C.-H., Gossett, T. G., Merican, T. C., and Gale, R. P., 1982, Cytomegalovirus immune plasma in bone marrow transplant recipients, Ann. Intern. Med. 97:11–18.PubMedGoogle Scholar
  167. Witherspoon, R. P., Storb, R., Ochs, H. D., Flournoy, N., Kopecky, K. J., Sullivan, K. M., Deeg, H. J., Sosa, R., Noel, D. R., Atkinson, K., and Thomas, E. D., 1981, Recovery of antibody production in human allogeneic marrow graft recipients: Influence of time posttransplantation, the presence or absence of chronic graft-versus-host disease, and antithymocyte globulin treatment, Blood 58:360–368.PubMedGoogle Scholar
  168. Witherspoon, R. P., Lum, L. G., Storb, R., and Thomas, E. D., 1982a, In vitro regulation of immunoglobulin synthesis after human marrow transplantation. II. Deficient T and non-T lymphocyte function within 3–4 months of allogeneic, syngeneic, or autologous marrow grafting for hematologic malignancy, Blood 59:844.PubMedGoogle Scholar
  169. Witherspoon, R., Kopecky, K., Storb, R., Flournoy, M., Sullivan, K. M., Sosa, R., Deeg, H. J., Ochs, H., Cheever, M. A., Fefer, A., and Thomas, E. D., 1982b, Immunologic recovery following syngeneic marrow transplantation for hemotologic malignancy: A comparison of 48 syngeneic and 153 allogeneic recipients, Transplantation 33:143–149.PubMedCrossRefGoogle Scholar
  170. Witherspoon, R., Lum, L., Storb, R., and Thomas, E. D., 1983, Transplant-related immune deficiency in man, in: Recent Advances in Bone Marrow Transplantation (R. P. Gale, ed.), Alan R. Liss, New York, pp. 473–482.Google Scholar
  171. Woods, W. G., Dehner, L. P., Nesbit, M. E., Krivit, W., Coccia, P. F., Ramsay, N. K. C., Kim, T. H., and Kersey, J. H., 1980, Fatal venoocclusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation, Am. J. Med. 68:285–290.PubMedCrossRefGoogle Scholar
  172. Woods, W. G., Nesbit, M. E., Ramsay, N. K., Krivit, W., Kim, T. H., Goldman, A., McGlave, P. B., and Kersey, J. H., 1983, Intensive therapy followed by bone marrow transplantation for patients with acute lymphocytic leukemia in second or subsequent remission: Determination of prognostic factors (A report from the University of Minnesota Bone Marrow Transplantation Team), Blood 61:1182–1189.PubMedGoogle Scholar
  173. Zwaan, F. E., Jansen, J., and Noordijk, E. M., 1980a, Bone-marrow transplantation in acute myeloid leukemia (AML) during the first remission. The Leiden experience, Blut 41:216–220.Google Scholar
  174. Zwaan, F. E., 1980b, Bone marrow transplantation for acute leukaemia in remission—European results, Blut 41:208–213.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Alexander Fefer
    • 1
    • 2
  • Martin A. Cheever
    • 1
    • 2
  • Philip D. Greenberg
    • 1
    • 2
  • C. Dean Buckner
    • 1
    • 2
  • Rainer Storb
    • 1
    • 2
  • E. Donnall Thomas
    • 1
    • 2
  1. 1.Division of OncologyUniversity of Washington School of MedicineSeattleUSA
  2. 2.Fred Hutchinson Cancer Research CenterSeattleUSA

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