Application of Monoclonal Antibodies to Autologous Bone Marrow Transplantation

  • Robert C. BastJr.
  • Jerome Ritz


A number of studies in animal models have suggested that serotherapy might be capable of eliminating small numbers of tumor cells in vivo. Therapeutic activity has been documented using antisera against leukemias, lymphomas, and some solid tumors (Bernstein et al., 1982). However, for many years, trials of serotherapy for human cancer have been limited by the lack of availability of sufficient amounts of high-titered antiserum that does not react with vital host tissues. Recently, some success has been achieved in treating mycosis fungoides and other T-cell neoplasms using heteroantisera reactive with T-cell differentiation antigens (Fisher et al., 1978). Anecdotal accounts have noted responses after the infusion of some alloantisera, but in general serotherapy has had little demonstrable impact on most human cancers (Bernstein et al., 1982).


Pluripotent Stem Cell Chronic Myelogenous Leukemia Total Body Irradiation Chronic GVHD Autologous Bone Marrow Transplantation 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Robert C. BastJr.
    • 1
    • 2
    • 3
  • Jerome Ritz
    • 1
    • 2
    • 3
  1. 1.Divisions of Tumor Immunology and MedicineDana-Farber Cancer InstituteBostonUSA
  2. 2.Department of MedicineBrigham and Women’s HospitalBostonUSA
  3. 3.Department of MedicineHarvard Medical SchoolBostonUSA

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