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Regulation of Natural Killer Cell Activity

  • Ronald B. Herberman
  • Angela Santoni

Abstract

Natural killer (NK) cells have cytotoxic activity against a variety of tumor cells and also against some microorganisms or cells infected by microbial agents (for comprehensive review and detailed information, see Herberman and Holden, 1978, and Herberman, 1980, 1982). They may thereby serve as important effector cells in host resistance against disease. NK cells are present in virtually all individuals and can be activated rapidly by a wide variety of stimuli, and their activities do not depend on sensitization by antigens and the development of specific immune responses. Thus, these cells may function as a first line of defense against attack by neoplastic cells or infectious agents.

Keywords

Natural Killer Natural Killer Cell Cholera Toxin Phorbol Myristate Acetate Suppressor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Ronald B. Herberman
    • 1
  • Angela Santoni
    • 1
  1. 1.Biological Therapeutics Branch, Biological Response Modifiers Program, Division of Cancer TreatmentNational Cancer InstituteFrederickUSA

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