Proliferation and Differentiation Control Mechanisms in Myeloid Leukemia

  • Malcolm A. S. Moore


Studies of myeloid leukemic cell lines and primary cultures of leukemic bone marrow have yielded information on humoral regulation of growth and differentiation of myeloid cells and have revealed specific abnormalities in regulatory control that would appear to play important roles in the development and progression of hematopoietic neoplasia. Already considerable in vitro data have been accumulated to document the feasibility of the clinical application of such biological response modifiers as retinoic acid, interferon, tumor necrosis factor, prostaglandin E, and differentiation-inducing proteins in a strategy designed to revert malignant hematopoietic cells to a pattern of normal proliferation and differentiation, or to mediate their selective ablation.


Retinoic Acid Leukemic Cell Phorbol Ester Myeloid Leukemic Cell Myeloid Leukemic Cell Line 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Malcolm A. S. Moore
    • 1
  1. 1.Department of Developmental HematopoiesisSloan-Kettering Institute for Cancer ResearchNew YorkUSA

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