Inhibition of the Carcinogenic Process and of Expression of the Neoplastic Phenotype

  • John S. Bertram


Current interest in inhibitors of carcinogenesis stems from our increasing understanding of mechanisms of carcinogenesis, which in turn has been stimulated by the growing realization that the majority of human cancer is of environmental origin. Environmental studies of cancer incidence on a world-wide basis have revealed striking differences in the rates of such neoplasms as those of the colon, breast, and lung, which are common in the United States but occur much less frequently in non-Western societies (Doll et al., 1970). Of particular interest is the low incidence rate for breast cancer and the high rate for stomach cancer in Japan, which contrast with the high breast cancer and low stomach cancer rates in the U.S. That these differences are not primarily of racial origin is apparent in studies of Japanese migrants to the U.S., who begin to aquire incidence rates characteristic of the host country (Haenszel and Kurihara, 1968). Similarly, studies within the U.S. have shown wide geographaphic differences in cancer incidence, the highest levels being typically found in urban industrial settings. In contrast, some of the lowest incidence rates are found among groups such as Seventh-Day Adventists, whose life-style includes the prohibition of alcohol and tobacco, and a lacto-ovovegetarian diet.


Retinoic Acid Saturation Density Carcinogenic Process Retinyl Palmitate Synthetic Retinoid 



Eagle’s basal medium




benzpyrene/ferric oxide


cyclic AMP


cyclic GMP


cellular retinoic-acidbinding protein


cellular retinol-binding protein






N-4-(5-nitro-2-furyl)-2-thiazole formamide


fetal calf serum


heat-inactivated fetal calf serum


N-butyl-N-4-hydroxybutyl nitrosamine








mannosylretinyl phosphate




normal rat kidney


(plasma) retinol-binding protein


Roswell Park Memorial Institute


C3H/10T1/2 cell line


transformation frequency


12-O-tetradecanoyl phorbol-13-acetate




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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • John S. Bertram
    • 1
  1. 1.Grace Cancer Drug CenterRoswell Park Memorial InstituteBuffaloUSA

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