Monoclonal Antibodies to Human Neuroblastoma Cells and Other Solid Tumors

  • Frank Berthold


My own interest in and work with monoclonal antibodies to human tumor cells originated from diagnostic and therapeutic experiences in children with solid tumors. Therefore, this chapter attempts primarily to review the present status of the ability of monoclonal antibodies to meet clinical needs, to point out problems and restrictions with the current available antibodies, and to show recent approaches to overcome them. A brief look at the general potential of monoclonal antibodies to tumor cells is followed by an overview concerning the actual available antitumor antibodies and the necessary requirements for diagnostic and therapeutic use in cancer patients. Special problems like specificity and heterogeneity, as well as recent advances in cytological detection of bone marrow metastasis, in radioimmunoimaging of bone metastasis, and in therapeutic efforts are discussed in detail for antineuroblastoma antibodies, the field of my own special interest in clinic and laboratory.


Monoclonal Antibody Neuroblastoma Cell Minimal Residual Disease Hairy Cell Leukemia Human Neuroblastoma Cell 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Frank Berthold
    • 1
    • 2
  1. 1.Department of Human GeneticsUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.UniversitätskinderklinikGiessenFederal Republic of Germany

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