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Monoclonal Antibodies to Human Neuroblastoma Cells and Other Solid Tumors

  • Frank Berthold

Abstract

My own interest in and work with monoclonal antibodies to human tumor cells originated from diagnostic and therapeutic experiences in children with solid tumors. Therefore, this chapter attempts primarily to review the present status of the ability of monoclonal antibodies to meet clinical needs, to point out problems and restrictions with the current available antibodies, and to show recent approaches to overcome them. A brief look at the general potential of monoclonal antibodies to tumor cells is followed by an overview concerning the actual available antitumor antibodies and the necessary requirements for diagnostic and therapeutic use in cancer patients. Special problems like specificity and heterogeneity, as well as recent advances in cytological detection of bone marrow metastasis, in radioimmunoimaging of bone metastasis, and in therapeutic efforts are discussed in detail for antineuroblastoma antibodies, the field of my own special interest in clinic and laboratory.

Keywords

Monoclonal Antibody Neuroblastoma Cell Minimal Residual Disease Hairy Cell Leukemia Human Neuroblastoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abramson, C. S., Kersey, J. H., and LeBien, T. W., 1981, A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage, J. Immunol. 126:83–88.Google Scholar
  2. Accolla, R. S., Carrel, S., and Mach, J. P., 1980, Monoclonal antibodies specific for carcinoembryonic antigen and produced by two hybrid cell lines, Proc. Natl. Acad. Sci. USA 77:563.CrossRefGoogle Scholar
  3. Andrews, P. W., Goodfellow, P. N., Shevinsky, L. H., Bronson, D. L., and Knowles, B. B., 1982, Cell-surface antigens of a clonal human embryonal carcinoma cell line: Morphological and antigenic differentiation in culture, Int. J. Cancer 29:523–531.CrossRefGoogle Scholar
  4. Bast, R. C., Feeney, M., Lazarus, H., Nadler, L. M., Colvin, R. B., and Knapp, R. C., 1981, Reactivity of a monoclonal antibody with human ovarian carcinoma, J. Clin. Invest. 68:1331.CrossRefGoogle Scholar
  5. Becker, G. J., Hancock, W. W., Kraft, N., Lanyon, H. C., and Atkins, R. C., 1981, Monoclonal antibodies to human macrophage and leucocyte common antigens, Pathology 13:669.CrossRefGoogle Scholar
  6. Berthold, F., Kracht, J., Lampert, F., Millar, T. J., Müller, T. H., Reither, M., and Unsicker, K., 1982, Ultrastructural, biochemical and cell-culture studies of a presumed extraskeletal Ewing’s sarcoma with special reference to differential diagnosis from neuroblastoma, J. Cancer Res. Clin. Oncol. 103:293–304.CrossRefGoogle Scholar
  7. Berthold, F., Treuner, J., Brandeis, W. E., Evers, G., Haas, R. J., Harms, D., Jürgens, H., Kaatsch, P., Michaelis, J., Niethammer, D., Prindull, G., Riehm, H., Winkler, K., and Lampert, F., 1982, Neuroblastomstudie NBL 79 der Gesellschaft für Pädiatrische Oukologie—Zwischenbericht nach 2 Jahren, Klin. Paediatr. 194:262–263.CrossRefGoogle Scholar
  8. Boucheix, C., Perrot, J. Y., Mirshani, M., Fournier, N., Billard, M., Bernadou, A., and Rosenfeld, C., 1982, Monoclonal antibodies against acute lymphoblastic leukemia differentiation antigens (meeting abstract), in: First International Workshop on Human Leukocyte Differentiation Antigens, Hospital Saint-Louis, Paris, France, p. AP-4.Google Scholar
  9. Brown, J. M., Graeger, J. A., and Das Gupta, T. K., 1983, Tumor localization studies in sarcoma patients using a radiolabeled monoclonal antibody (meeting abstract), Hybridoma 2:136.Google Scholar
  10. Carrel, S., De Tribolet, N., and Mach, J.-P., 1982, Expression of neuroectodermal antigens common to melanomas, gliomas, and neuroblastomas. I. Identification by monoclonal anti-melanoma and anti-glioma antibodies, Acta Neuropathol. (Berl.) 57:158–164.CrossRefGoogle Scholar
  11. Cuttitta, F., Rosen, S., Gazdar, A. F., and Minna, J. D., 1981, Monoclonal antibodies that demonstrate specificity for several types of human lung cancer, Proc. Natl. Acad. Sci. USA 78:4591–4595.CrossRefGoogle Scholar
  12. Danon, Y. L., Rayner, S. A., Kaminsky, E., and Seeger, R. C., 1981, Human neuroblastoma and acute leukemia cells common antigen defined with monoclonal antibody (meeting abstract), Isr. J. Med. Sci. 17:1096.Google Scholar
  13. Dearnaley, D. P., Sloane, J. P., Ormerod, M. G., Steele, K., Coombes, R. C., Glink, H. M., Powles, T. J., Ford, H. T., Gazet, J. T., and Neville, A. M., 1981, Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen, Br. J. Cancer 44:85.CrossRefGoogle Scholar
  14. Deng, C., El-Awar, N., Cicciarelli, J., Terasaki, P. I., Billing, R., and Lagasse, L., 1981, Cytotoxic monoclonal antibody to a human leiomyosarcoma, Lancet 1:403–405.CrossRefGoogle Scholar
  15. Doering, L. C., and Federoff, S., 1982, Isolation and identification of neuroblast precursor cells from mouse neopallium, Dev. Brain Res. 5:229–233.CrossRefGoogle Scholar
  16. Edwards, P. A. W., 1981, Some properties and applications of monoclonal antibodies, Biochem. J. 200:1.Google Scholar
  17. Eisenbarth, G. S., Walsh, F. S., and Nirenberg, M., 1979, Monoclonal antibody to a plasma membrane antigen of neurons, Proc. Natl. Acad. Sci. USA 76:4913–4917.CrossRefGoogle Scholar
  18. Evans, A. E., Gerson, J., and Schnaufer, L., 1976, Spontaneous regression of neuroblastoma, Natl. Cancer Inst. Monogr. 44:49.Google Scholar
  19. Finklestein, J. Z., Klemperer, M. R., Evans, A., Bernstein, I., Leikin, S., McCreadie, S., Grosfeld, J., Hittle, R., Weiner, J., Sather, H., and Hammond, D., 1979, Multiagent chemotherapy for children with metastatic neuroblastoma: A report from children’s cancer study group, Med. Pediatr. Oncol. 6:179–188.CrossRefGoogle Scholar
  20. Frankel, A. E., Rouse, R. V., and Herzenberg, L. A., 1982, Human prostate-specific and shared differentiation antigens defined by monoclonal antibodies, Proc. Natl. Acad. Sci. USA 79:903.CrossRefGoogle Scholar
  21. Galloway, D. R., Imai, K., Ferrone, S., and Reisfeld, R. A., 1981, Molecular profiles of human melanoma-associated antigens, Fed. Proc. 40:231.Google Scholar
  22. Ghose, T., Ramakrishnan, S., Kulkarni, P., Blair, A. H., Vaughan, K., Nolido, H., Norvell, S. T., Belitsky, P., and Bonavida, B., 1981, Use of antibodies against tumor-associated antigens for cancer diagnosis and treatment, Transplant. Proc. 13:1970–1972.Google Scholar
  23. Goldman, A., Pritchard, J., and Kemshead, J. T., 1982, Selective localization of radiolabeled monoclonal antibodies to human neuroblastoma xenografts in a nude mouse model (meeting abstract), in: Fourteenth Annual Meeting of the International Society of Pediatric Oncology, Berne, Switzerland, pp. A12.Google Scholar
  24. Greaves, M. F., Verbi, W., Kemshead, J., and Kennett, R. H., 1980, A monoclonal antibody identifying a cell surface antigen shared by common acute lymphoblastic leukemias and B lineage cells, Blood 56:1141–1144.Google Scholar
  25. Green, A. A., Hayes, F. A., and Huster, H. O., 1981, Sequential cyclophosphamide and doxorubicine for induction of complete remission in children with disseminated neuroblastoma, Cancer 48:2310.CrossRefGoogle Scholar
  26. Griffin, J. D., Ritz, J., Nadler, L. M., and Schlossman, S. F., 1981, Expression of myeloid differentiation antigens on normal and malignant myeloid cells, J. Clin. Invest. 68:932.CrossRefGoogle Scholar
  27. Hancock, W. W., Becker, G. J., and Atkins, R. C., 1982, A comparison of fixatives and immu-nohistochemical techniques for use with monoclonal antibodies to cell surface antigens, Am. J. Clin. Pathol. 78:825–831.Google Scholar
  28. Hellström, K. E., Hellström, I., and Brown, J. P., 1982, Human tumor-associated antigens identified by monoclonal antibodies, Springer Semin. Immunopathol. 5:127–146.CrossRefGoogle Scholar
  29. Helson, L., 1975, Management of disseminated neuroblastoma, Cancer 25:264–267.Google Scholar
  30. Herlyn, M., Steplewski, Z., Herlyn, D., and Koprowski, H., 1979, Colorectal carcinoma-specific antigen: Detection by means of monoclonal antibodies, Proc. Natl. Acad. Sci. USA 76:1438.CrossRefGoogle Scholar
  31. Herlyn, M., Clark, W. H., Mastangelo, M. J., Guerry, D. J. V., Elder, D. E., LaRosse, D., Hamilton, R., Bondi, E., Tuthill, R., and Steplewski, Z., 1980, Specific immunoreactivity of monoclonal anti-melanoma antibodies, Cancer Res. 40:3602.Google Scholar
  32. Hollinshead, A. C., 1982, Human lung tumor markers—Biological basis and clinical studies, CancerDetect. Prev. 5:255.Google Scholar
  33. Hosoi, S., Nakamura, T., Higashi, S., Yamamuro, T., Toyama, S., Shinomiya, K., and Mikawa, H., 1982, Detection of human osteosarcoma-associated antigen(s) by monoclonal antibodies, Cancer Res. 42:654.Google Scholar
  34. Howe, A. J., Seeger, R. C., Molinaro, G. A., and Ferrone, S., 1980, HLA-DR (Ia-like) antigens on human tumor cells, Clin. Res. 28:104A.Google Scholar
  35. Howe, A. J., Seeger, R. C., Molinaro, G. A., and Ferrone, S., 1981, Analysis of human tumor cells for Ia-like antigens with monoclonal antibodies, J. Natl. Cancer Inst. 66:827–829.Google Scholar
  36. Howman-Giles, R. B., Gilday, G. L., and Ash, J. M., 1979, Radionuclide skeletal survey in neuroblastoma, Radiology 131:497.Google Scholar
  37. Hurwitz, E., and Danon, Y. L., 1982, A conjugate of adriamycin-anti-neuroblastoma monoclonal antibodies inhibits neuroblastoma cell in vitro (meeting abstract), in: Tenth Annual Meeting of the International Society for Oncodevelopmental Biology and Medicine, Sapporo, Japan, p. A68.Google Scholar
  38. Imai, K., Ny, A. K., and Ferrone, S., 1981, Characterization of monoclonal antibodies to human melanoma-associated antigens, J. Natl. Cancer Inst. 66:489.Google Scholar
  39. Imashuku, S., Todo, S., Amano, T., Mizukawa, K., Sukimoto, T., and Kusunoki, T., 1977, Cyclic AMP in neuroblastoma, ganglioneuroma and sympathie ganglia, Experientia 33:1507.CrossRefGoogle Scholar
  40. Izant, J. G., and Mcintosh, J. R., 1980, Microtubule-associated proteins: A monoclonal antibody to MAP2 binds to differentiated neurons, Proc. Natl. Acad. Sci. USA 77:4741–4745.CrossRefGoogle Scholar
  41. Jonak, Z. L., Kennett, R. H., and Bechtol, K. B., 1982, Detection of neuroblastoma cells in human bone marrow using a combination of monoclonal antibodies, Hybridoma 1:349–368.CrossRefGoogle Scholar
  42. Kapadia, A., Feizi, T., and Evans, M. J., 1981, Changes in the expression and polarization of blood group I and i antigens in post-implanatation embryos and teratocarcinomas of mouse associated with cell differentiation, Exp. Cell Res. 131:185–195.CrossRefGoogle Scholar
  43. Kaufman, R. A., Thrall, J. H., Keyes, J. W., Jr., Brown, M. L., and Zakem, J. F., 1978, False negative bone scans in neuroblastoma metastatic to the ends of long bones, Am. J. Radiol. 130:131.Google Scholar
  44. Kemshead, J. T., Bicknell, D., and Greaves, M. F., 1981a, A monoclonal antibody detecting an antigen shared by neural and granulocytic cells, Pediatr. Res. 15:1282–1286.CrossRefGoogle Scholar
  45. Kemshead, J. T., Greaves, M. F., Walsh, F., Cahyen, A., and Parkhouse, M., 1981b, Monoclonal antibodies to human neuroblastoma reveal a heterogeneity in antigenic expression within the tumor (meeting abstract), Proc. Am. Assoc. Cancer Res. 22:399.Google Scholar
  46. Kemshead, J. T., Walsh, F., Pritchard, J., and Greaves, M., 1981c, Monoclonal antibody to ganglioside GQ discriminates between haemopoietic cells and infiltrating neuroblastoma tumor cells in bone marrow, Int. J. Cancer 27:447–452.CrossRefGoogle Scholar
  47. Kemshead, J. T., Fritschy, J., Asser, U., Sutherland, R., and Greaves, M. F., 1982a, Monoclonal antibodies defining markers with apparent selectivity for particular haemopoietic cell types may also detect antigens on cells of neural crest origin, Hybridoma 1:109–123.CrossRefGoogle Scholar
  48. Kemshead, J. T., Rembaum, A., Ugelstad, J., and Malpas, J. S., 1982b, The potential use of monoclonal antibodies and microspheres containing magnetic compounds to remove neuroblastoma cells from bone marrow, Proc. Am. Soc. Clin. Oncol. 1:C-143.Google Scholar
  49. Kemshead, J. T., Ugelstad, J., Rembaum, A., and Gibson, F., 1982c, Monoclonal antibodies attached to microspheres containing magnetic compounds, used to remove neuroblastoma cells from bone marrow taken for autologous transplantation (meeting abstract), in: Fourteenth Annual Meeting of the International Society of Pediatric Oncology, Berne, Switzerland, p. A21.Google Scholar
  50. Kemshead, J. T., Fritschy, J., Goldman, A., Malpas, J. S., and Pritchard, J., 1983, Use of panels of monoclonal antibodies in the differential diagnosis of neuroblastoma and lymphoblastic disorders, Lancet 1:12–15.CrossRefGoogle Scholar
  51. Kennett, R. H., and Gilbert, F., 1979, Hybrid myelomas producing antibodies against a human neuroblastoma antigen present on fetal brain, Science 203:1120–1121.CrossRefGoogle Scholar
  52. Kennett, R. H., Jonak, Z. L., Momoi, M., Glick, M. C., and Lampson, L. A., 1982, Analysis of cell surface molecules on human neuroblastoma cells and leukemia ceils, in: Proceedings of the FirstJohn Jacob Abel Symposium on Drug Development (J. T. August, ed.), The Johns Hopkins University School of Medicine, Baltimore, Maryland, pp. 91–107.Google Scholar
  53. Kersey, J. H., LeBien, T. W., Abramson, C. S., Newman, R., Sutherland, R., and Greaves, M., 1981, p24: A human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody, J. Exp. Med. 153:726–731.Google Scholar
  54. Koprowski, H., Steplewski, Z., Herlyn, D., and Herlyn, M., 1978, Study of antibodies against human melanoma produced by somatic cell hybrids, Proc. Natl. Acad. Sci. USA 75:3405.CrossRefGoogle Scholar
  55. Koprowski, H., Herlyn, M., Steplewski, Z., and Sears, H. F., 1981, Specific antigen in serum of patients with colon carcinoma, Science 212:53.CrossRefGoogle Scholar
  56. Kupchik, H. Z., Zurawski, V. R., Hurrel, J. G., Zamcheck, N., and Black, P. H., 1981, Monoclonal antibodies to carcinoembryonic antigen produced by somatic cell fusion, Cancer Res. 41:3306.Google Scholar
  57. Lampson, L. A., and Fisher, C. A., 1982, Monoclonal antibody analysis of human neural tumors (meeting abstract), Fed. Proc. 41:411.Google Scholar
  58. Lee, V., Trojanowski, J. Q., and Schlaepfer, W. W., 1982a, Induction of neurofilament triplet proteins in PC12 cells by nerve growth factor, Brain Res. 238:169–180.CrossRefGoogle Scholar
  59. Lee, V., Wu, H. L., and Schlaepfer, W. W., 1982b, Monoclonal antibodies recognize individual neurofilament triplet proteins, Proc. Natl. Acad. Sci. USA 79:6089–6092.CrossRefGoogle Scholar
  60. Liao, S.-K., Clarke, B. J., Kwong, P. C., Brickenden, A., Gallie, B. L., and Dent, P. B., 1981, Common neuroectodermal antigens on human melanoma, neuroblastoma, retinoblastoma, glioblastoma and fetal brain revealed by hybridoma antibodies raised against melanoma cells, Eur. J. Immunol. 11:450–454.CrossRefGoogle Scholar
  61. Mazauric, T., Mitchell, K. F., Letchworth, G. J., Koprowski, H., and Steplewski, Z., 1982, Monoclonal antibody-defined human lung cell surface protein antigens, Cancer Res. 42:150.Google Scholar
  62. Mcllhinney, R. A. J., Dinsdale, E., and Neville, A. M., 1981, A monoclonal antibody to the murine teratoma F9: An immunocytochemical demonstration of tissue specificity, Diagn. Histopathol. 4:129.Google Scholar
  63. McMichael, A. J., Pilch, J. R., Galfré, G., Manson, D. Y., Fabre, J. W., and Milstein, C., 1979, A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody, Eur. J. Immunol. 9:205–210.CrossRefGoogle Scholar
  64. Miller, R. A., and Levy, R., 1981, Response of cutaneous T cell lymphoma to therapy with hybridoma monoclonal antibody, Lancet 2:226.CrossRefGoogle Scholar
  65. Miller, R. A., Maloney, D. G., Warnke, R., and Levy, R., 1982, Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody, N. Engl. J. Med. 306:517.CrossRefGoogle Scholar
  66. Minna, J., 1981, Preparation and potential clinical applications of monoclonal antibodies against human tumors (meeting abstract), in: Monoclonal Antibodies and Breast Cancer, July 29, 1981, NCI—Veterans Administration Medical Oncology Branch, Bethesda, Maryland.Google Scholar
  67. Mitchell, K. F., 1980, A carcinoembryonic antigen (CEA) specific monoclonal hybridoma antibody that reacts only with high molecular weight CEA, Cancer Immunol. 10:1.CrossRefGoogle Scholar
  68. Mitchell, K. F., Fuhrer, J. P., Steplewski, Z., and Koprowski, H., 1980, Biochemical characterization of human melanoma cell surfaces: Dissection with monoclonal antibodies, Proc. Natl. Acad. Sci.USA 77:7287.CrossRefGoogle Scholar
  69. Momoi, M., Kennett, R. H., and Glick, M. C., 1980, A membrane glycoprotein from human neuroblastoma cells isolated with the use of a monoclonal antibody, J. Biol. Chem. 255:11914–11921.Google Scholar
  70. Moshakis, V., Mcllhinney, R. A. J., Raghaven, D., and Neville, A. M., 1981, Monoclonal antibodies to detect human tumors: An experimental approach, J. Clin. Pathol. 34:314.CrossRefGoogle Scholar
  71. Naritoku, W. Y., and Taylor, C. R., 1982, A comparative study of the use of monoclonal antibodies using three different immunohistochemical methods: An evaluation of monoclonal and polyclonal antibodies against human prostatic acid phosphatase, J. Histochem. Cytochem. 30:253.CrossRefGoogle Scholar
  72. Neville, A. M., Foster, C. S., Moshakis, V., and Gore, M., 1982, Monoclonal antibodies and human tumor pathology, Hum. Pathol. 13:1067–1081.CrossRefGoogle Scholar
  73. Ninane, J., Pritchard, J., and Malpas, J. S., 1981, Chemotherapy of advanced neuroblastoma: Does adriamycin contribute?, Arch. Dis. Child. 56:544.CrossRefGoogle Scholar
  74. Nitschke, R., Cangir, A., Crist, W., and Berry, D. H., 1980, Intensive chemotherapy for metastatic neuroblastoma: A southwest oncology group study, Med. Pediatr. Oncol. 8:281.CrossRefGoogle Scholar
  75. Nossal, G. J., 1976, Spontaneous regression of cancer: Summary and profile for the future, Natl.Cancer Inst. Monogr. 44:145.Google Scholar
  76. Osborn, M., Altmannsberger, M., Shaw, G., Schauer, A., and Weber, K., 1982, Various sympathetic derived human tumors differ in neurofilament expression, Virchows Arch. 40:141–156.CrossRefGoogle Scholar
  77. Prasad, K. N., 1975, Differentiation of neuroblastoma cells in culture, Biol. Rev. 50:129.CrossRefGoogle Scholar
  78. Price, M. R., Pimm, M. V., and Baldwin, R. W., 1982, Complement dependent cytotoxicity of anti-human osteogenic sarcoma monoclonal antibodies, Brit. J. Cancer 46:601.CrossRefGoogle Scholar
  79. Pritchard, J., Malpas, J. S., and Kemshead, J. T., 1982, Monoclonal antibodies help in the differential diagnosis of “small round cell” childhood tumors (meeting abstract), in: Fourteenth Annual Meeting of the International Society of Pediatric Oncology, Berne, Switzerland, p. A10.Google Scholar
  80. Rauvala, H., and Finne, J., 1979, Structural similarity of the terminal carbohydrate sequences of glycoproteins and glycolipids, FEBS Lett. 97:1.CrossRefGoogle Scholar
  81. Reif, A. E., and Allen, J. M. V., 1964, The AKR thymic antigen and its distribution in leukemias and nervous tissue, J. Exp. Med. 120:413.CrossRefGoogle Scholar
  82. Reinherz, E. L., and Schlossman, S. F., 1982, The characterization and function of human immunoregulatory T lymphocyte subsets, Pharmacol. Rev. 34:17–22.Google Scholar
  83. Reinherz, E. L., Kung, P. C., Goldstein, G., Levey, R. H., and Schlossman, S. F., 1980, Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage, Proc. Natl. Acad. Sci. USA 77:1588–1592.CrossRefGoogle Scholar
  84. Revoltella, R. P., Businaro, R., Lauro, G., and Toesca, A., 1982, Tumor-associated neural differentiation antigens detected on C1300 neuroblastoma cells by hybridoma monoclonal autoantibodies, Cell. Immunol. 68:75–92.CrossRefGoogle Scholar
  85. Reynolds, C. P., and Smith, R. G., 1981, Monoclonal antibody to human neuroblastoma-associated antigen (meeting abstract), Proc. Am. Assoc. Cancer Res. 22:402.Google Scholar
  86. Reynolds, C. P., and Smith, R. G., 1982, A sensitive immunoassay for human neuroblastoma cells, in: Hybridomas in Cancer Diagnosis and Treatment (M. S. Mitchell and H. F. Oettgen, eds.), Raven Press, New York, pp. 235–240.Google Scholar
  87. Ritz, J., and Schlossman, S. F., 1982, Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma, Blood 59:1–11.Google Scholar
  88. Ruddon, R. W., 1982, Tumor markers in the recognition and management of poorly differentiated neoplasms and cancers of unknown primary, Semin. Oncol. 9:416–426.Google Scholar
  89. Saxton, R. E., Mann, B. D., Irie, R. F., Morton, D. L., and Burk, M. W., 1982a, Monoclonal antibodies to human melanoma: Identification of two unique proteins on the tumor cell membrane (meeting abstract), Proc. Am. Assoc. Cancer Res. 23:1040.Google Scholar
  90. Saxton, R. E., Mann, B. D., Morton, D. L., and Burk, M. W., 1982b, Monoclonal antibodies to 125 kd and 95 kd proteins on human melanoma cells: Comparison with other monoclonal-defined melanoma antigens, Hybridoma 1:433.CrossRefGoogle Scholar
  91. Schnegg, J. F., Diserens, A. C., Carrel, S., Accolla, R. S., and de Tribolet, N., 1981, Human glioma-associated antigens detected by monoclonal antibodies, Cancer Res. 41:1209–1213.Google Scholar
  92. Schwab, U., Stein, H., Gerdes, J., Lemke, H., Kirchner, H., Schaadt, M., and Diehl, V., 1982, Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin’s disease and a subset of normal lymphoid cells, Nature 299:65–67.CrossRefGoogle Scholar
  93. Seeger, R. C., 1982a, Expression of human Thy-1 by neuroblastoma, glioma, sarcoma, and teratoma cells, in: Hybridomas in Cancer Diagnosis and Treatment (M. S. Mitchell and H. F. Oettger, eds.), Raven Press, New York, pp. 231–234.Google Scholar
  94. Seeger, R. C., 1982b, Neuroblastoma: Clinical perspectives, monoclonal antibodies, and retinoic acid, Ann. Intern. Med. 97:873–884.Google Scholar
  95. Seeger, R. C., Zeltzer, P. M., and Rayner, S. A., 1979, Onco-neural antigen: A new neural differentiation antigen expressed by neuroblastoma, oat cell carcinoma, Wilm’s tumor, and sarcoma cells, J. Immunol. 122:1548–1555.Google Scholar
  96. Seeger, R. C., Danon, Y. L., Zeltzer, P. M., Maidman, J. E., and Rayner, S. A., 1980, Expression of fetal antigens by human neuroblastoma cells, Prog. Cancer Res. Ther. 12:344.Google Scholar
  97. Seeger, R. C., Rosenblatt, H. M., Imai, K., and Ferrone, S., 1981, Common antigenic determinants on human melanoma, glioma, neuroblastoma, and sarcoma cells defined with monoclonal antibodies, Cancer Res. 41:2714–2717.Google Scholar
  98. Seeger, R. C., Danon, Y. L., Rayner, S. A., and Hoover, F., 1982, Definition of a Thy-1 determinant on human neuroblastoma, glioma, sarcoma, and teratoma cells with a monoclonal antibody, J. Immunol. 128:983–989.Google Scholar
  99. Sidell, N., 1982, Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro, J. Natl. Cancer Inst. 68:589.Google Scholar
  100. Sikora, K., and Wright, R., 1981, Human monoclonal antibodies to lung-cancer antigens, Br. J. Cancer 43:696.CrossRefGoogle Scholar
  101. Solter, D., and Knowles, B. B., 1978, Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1), Proc. Natl. Acad. Sci. USA 75:5565–5569.CrossRefGoogle Scholar
  102. Stein, H., Gerdes, J., Schwab, U., Lemke, H., Mason, D. Y., Ziegler, A., Schienle, W., and Diehl, V., 1982, Identification of Hodgkin and Sternberg-Reed cells as a unique cell type derived from a newly-detected small-cell population, Int. J. Cancer 30:445–459.CrossRefGoogle Scholar
  103. Sternberger, L. A., 1979, Immunocytochemistry, Wiley, New York, pp. 104–169.Google Scholar
  104. Sty, J. R., Babbitt, D. P., Casper, J. T., and Boedecker, R. A., 1979, 99 mTc-methylene diphosphonate imaging in neural crest tumors, Clin. Nucl. Med. 4:12.CrossRefGoogle Scholar
  105. Susimoto, T., Sawada, T., Kusunoki, T., and Minowda, J., 1982, Presence of neuroblastoma surface membrane antigens cross-reacting with monoclonal antibody primarily developed against hematopoietic cells (meeting abstract), in: Proceedings of the Japanese Cancer Association 41st Annual Meeting, Osaka, Japan, p. 425.Google Scholar
  106. Tank, A. W., and Weiner, N., 1982, Induction of tyrosine hydroxylase by glucocorticoids in mouse neuroblastoma cells: Enhancement of the induction by cyclic AMP, Mol. Pharmacol. 22:421–430.Google Scholar
  107. Trojanowski, J. Q., Lee, V., Pillsbury, N., and Lee, S., 1982, Neuronal origin of human esthesioneuroblastoma demonstrated with anti-neurofilament monoclonal antibodies, N. Engl. J. Med. 307:159–161.CrossRefGoogle Scholar
  108. Uotila, M., Engvall, E., and Rouslahti, E., 1980, Monoclonal antibodies to human alphafetoprotein, Mol. Immunol. 17:791.CrossRefGoogle Scholar
  109. Weinstein, J. N., Parker, R. J., Keenan, A. M., Dower, S. K., Morse III, H. C., and Sieber, S. M., 1982, Monoclonal antibodies in the lymphatics: Toward the diagnosis and therapy of tumor metastases, Science 218:1334–1337.CrossRefGoogle Scholar
  110. Wikstrand, C. J., and Bigner, D. D., 1982, Expression of human fetal brain antigens by human tumors of neuroectodermal origin as defined by monoclonal antibodies, Cancer Res. 42:267–275.Google Scholar
  111. Wikstrand, C. J., Pegram, C. N., and Bourdon, M. A., 1982, Expression of human fetal brain antigens (FBA) by human glioblastoma (HGL) cells as defined by monoclonal antibodies (MCA) (meeting abstract), Proc. Am. Assoc. Cancer Res. 22:304.Google Scholar
  112. Wikstrand, C. J., Bigner, S. P., and Bigner, D. D., 1982a, Antigenic heterogeneity of an established human glioma cell line (HGCL) and eight single cell derived clones as defined by specific anti-glioma monoclonal antibodies (MCA) (meeting abstract), Proc. Am. Assoc. Cancer Res. 23:1070.Google Scholar
  113. Wikstrand, C. J., Bourdon, M. A., Pegram, C. N., and Bigner, D. D., 1982b, Human fetal brain antigen expression common of tumors of neuroectodermal tissue origin, J. Neuroimmunol. 3:43–62.CrossRefGoogle Scholar
  114. Yeh, M., Hellström, J., Brown, J. P., Warner, G. A., and Hranson, J. A., 1979, Surface antigens of human melanoma identified by monoclonal antibody, Proc. Natl. Acad. Sci. USA 76:2927.CrossRefGoogle Scholar
  115. Young, G., and L’Heureux, P. L., 1978, Extraosseous tumor uptake of 99m technetium phosphate compounds in children with abdominal neuroblastoma, Pediatr. Radiol. 7:159.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Frank Berthold
    • 1
    • 2
  1. 1.Department of Human GeneticsUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.UniversitätskinderklinikGiessenFederal Republic of Germany

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