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Monoclonal Antibodies and Immunoparasitology

  • S. Michael Phillips
  • Deni M. Zodda

Abstract

The newly emerging discipline of immunoparasitology has extensively borrowed from and contributed to the more general field of immunology. Initially immunoparasitology benefited from technology developed by the more advanced discipline of immunology. More recently immunoparasitology has developed to the point that it clearly is capable of making significant and unique contributions to our understanding of immune response mechanisms. For example, vital information has been provided on the role of the eosinophil, mechanisms of genesis and modulation of granulomatous hypersensitivity, and genetic control of both host and parasite responses during infection. Clearly the approaches in immunoparasitology have become increasingly concordant to those of general immunology. Hence, it comes as no surprise that monoclonal antibody technology has been embraced by immunoparasitology and extensively utilized in the study of parasitic diseases. Areas of emphasis have included the preparation of purified reagents and the selective identification of antigenic determinants involved in antiparasite reactions. In addition to these general areas, there are also areas of emphasis unique to the field of immunoparasitology. These include:
  1. 1.

    Seroepedemiological studies to assess the incidence, prevalence, and morbidity of parasitic diseases.

     
  2. 2.

    The preparation of reagents for use in vaccines for either immunoprophylaxis or the control of morbidity.

     
  3. 3.

    The elucidation of mechanisms of resistance and morbidity in both experimental and clinical infections.

     

Keywords

Monoclonal Antibody Adult Worm Protective Antigen Toxoplasma Gondii Schistosoma Mansoni 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • S. Michael Phillips
    • 1
  • Deni M. Zodda
    • 2
  1. 1.Allergy and Immunology SectionUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.SmithKline DiagnosticsSunnyvaleUSA

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