Membrane Permeability in Porcine Malignant Hyperthermia

  • K. S. Cheah
  • A. M. Cheah
Part of the Biomembranes book series (B, volume 12)


Malignant hyperthermia is an inherited (Gronert, 1980; Britt et al., 1969, 1978; Eikelenboom et al., 1978; Ellis et al., 1978; Isaacs, 1978; Reske-Nielson, 1978; Webb and Jordan, 1978; Williams and Lasley, 1977; Kalow and Britt, 1973; King et al., 1972; Parikh and Thomson, 1972; Isaacs and Barlow, 1970; Denborough and Lovell, 1960) disease of skeletal muscle (Cheah, 1981; Cheah and Cheah, 1981a,b; Denborough, 1980; Gallant et al., 1979, 1980; Gronert, 1980; Gronert et al., 1977a, 1980a; Okumura et al., 1980; Britt, 1974, 1979; Harriman et al., 1978; Nelson et al., 1975; Moulds and Denborough, 1974; Berman and Kench, 1973; Clark et al., 1973; Ellis et al., 1973; Harrison, 1973; Relton et al., 1973; Jones et al., 1972; Berman et al., 1970; Britt and Kalow, 1970a; Snyder et al., 1967) in which the syndrome can be initiated in stress-susceptible pigs by environmental or physiological stress such as changes in temperature, excitement, and transportation (Gronert, 1980; Williams et al., 1975; Allen et al., 1970b, 1974; Topel et al., 1968) or following anesthesia in both humans and pigs with either halothane (Denborough, 1980; Gronert, 1980; Webb, 1980; Gronert and Theye, 1976a; Nelson et al., 1972, 1975; Jones et al., 1972, 1973; Hall et al., 1972; Berman et al., 1970; Harrison et al., 1968, 1969) or suxamethonium (Halsall and Ellis, 1979; Gronert and Theye, 1976b; Lister et al., 1974; Hall et al., 1966).


Sarcoplasmic Reticulum Malignant Hyperthermia Phosphorylase Kinase Longissimus Dorsi Muscle Skeletal Muscle Mitochondrion 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • K. S. Cheah
    • 1
  • A. M. Cheah
    • 1
  1. 1.Muscle Biology Division Agricultural and Food Research CouncilMeat Research InstituteLangford, BristolUK

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