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The Dynamic State of Membrane Lipids: The Significance of Lipid Exchange and Transfer Reactions to Biomembrane Composition, Structure, Function, and Cellular Lipid Metabolism

  • Frank P. Bell
Part of the Biomembranes book series (B, volume 12)

Abstract

Biological membranes are highly organized structures that permit cells to interact with their environment in a selective fashion that is consistent with the needs and function of the particular cell. The diversity of lipid compositions that characterize various types of biological membranes (Cohen and Derksen, 1969; Sanslone et al., 1972; Zambrono et al., 1975; Comte et al., 1976) implies that the lipid composition is an important determinant of function in a particular membrane. In fact, cellular processes such as membrane fusion (Papahadjopoulos et al., 1973; Poste and Allison, 1973; Cullis and de Kruijff, 1979), lateral diffusion of membrane proteins (Edidin, 1974; Barrantes, 1979), and the regulation of membrane-bound enzymes (Farías et al., 1975; McMurchie and Raison, 1979; Kovatchev et al., 1981; Miyahara et al., 1981b) are intimately linked to the physical properties (e.g., fluidity) of the membrane which are largely determined by lipid composition at physiologic temperatures. One of the fascinating features of biological membranes is that their basic structure, function, and composition under a given set of conditions are maintained while the lipid molecules that constitute the membrane are in a dynamic state. The exchange and transfer of lipid molecules between membranes, between membranes and lipoproteins, and the movement of lipid molecules between the two halves of the biological bilayer membrane (“flip-flop”) attest to the dynamic state of membrane lipids (Bell, 1978).

Keywords

Cholesteryl Ester Membrane Fluidity Cholesteryl Ester Transfer Protein Lipid Molecule Exchange Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alderson, J. C. E., and Green, C. 1975, Enrichment of lymphocytes with cholesterol and its effect on lymphocyte activation, FEBS Lett. 52:208.PubMedCrossRefGoogle Scholar
  2. Arbogast, L. Y., Rothblat, G. H., Leslie, M. H., and Cooper, R. A., 1976, Cellular cholesterol ester accumulation induced by free cholesterol-rich lipid dispersions, Proc. Natl. Acad. Sci. USA 73:3680.PubMedCrossRefGoogle Scholar
  3. Backer, J. M., and Dawidowicz, E. A., 1981a, Mechanism of cholesterol exchange between phospholipid vesicles, Biochemistry 20:3805.PubMedCrossRefGoogle Scholar
  4. Backer, J. M., and Dawidowicz, E. A., 1981b, Transmembrane movement of cholesterol in small unilamellar vesicles detected by cholesterol oxidase, J. Biol. Chem. 256:586.PubMedGoogle Scholar
  5. Baldassare, J. J., and Silbert, D. F., 1979, Membrane phospholipid metabolism in response to sterol depletion: Compensatory compositional changes which maintain 3-O-methylglucose transport, J. Biol. Chem. 254:10078.PubMedGoogle Scholar
  6. Barrantes, F. J., 1979, Endogenous chemical receptors: Some physical aspects, Annu. Rev. Biophys. Bioeng. 8:287.PubMedCrossRefGoogle Scholar
  7. Barter, P. J., and Lally, J. I., 1979, In vitro exchanges of esterified cholesterol between serum lipoprotein fractions: Studies of humans and rabbits, Metabolism 28:230.PubMedCrossRefGoogle Scholar
  8. Bates, S., and Rothblat, G. H., 1974, Regulation of cellular sterol flux and synthesis by human serum lipoproteins, Biochim. Biophys. Acta 360:38.PubMedGoogle Scholar
  9. Bell, F. P., 1975, Cholesterol exchange between microsomal, mitochondrial, and erythrocyte membranes and its enhancement by cytosol. Biochim. Biophys. Acta 398:18.PubMedGoogle Scholar
  10. Bell, F. P., 1976a, Lipoprotein lipid exchange in biological systems, in: Low Density Lipoproteins (C. E. Day and R. S. Levy, eds.), pp. 111–133, Plenum Press, New York.CrossRefGoogle Scholar
  11. Bell, F. P., 1976b, Esterification of membrane-bound cholesterol by cell-free preparations of atherosclerotic rabbit arotas, Artery 2:519.Google Scholar
  12. Bell, F. P., 1977a, Cholesterol exchange: Evidence for a role in arterial cholesterol accumulation, in: Atherosclerosis: Metabolic, Morphologic, and Clinical Aspects (G. W. Manning and M. D. Haust, eds.), pp. 240–243, Plenum Press, New York.Google Scholar
  13. Bell, F. P., 1977b, Further studies on the characterization of the cholesterol-exchange factor from rat liver cytosol, Artery 3:98.Google Scholar
  14. Bell, F. P., 1978, Lipid exchange and transfer between biological lipid-protein complexes, Prog. Lipid Res. 17:207.PubMedCrossRefGoogle Scholar
  15. Bell, F. P., 1981a, Cholesterol esterification by rat adrenal gland: Inhibition by local anesthetics in vitro, Biochim. Biophys. Acta 666:58.PubMedGoogle Scholar
  16. Bell, F. P., 1981b, The effect of local anesthetics on arterial lipid metabolism: Inhibition of sterol esterification in vitro, Atherosclerosis 38:81.PubMedCrossRefGoogle Scholar
  17. Bell, F. P., 1983, Effect of chlorpromazine on lipid metabolism in aortas from cholesterol-fed rabbits and normal rats, in vitro: Inhibition of sterol esterification and modification of phospholipid synthesis, Exp. Mol. Pathol. 38:336.PubMedCrossRefGoogle Scholar
  18. Bell, F. P., and Hubert, E. V., 1981, Membrane-active agents: Effect of various anesthetics and chlorpromazine on arterial lipid metabolism, Atherosclerosis 39:517.PubMedCrossRefGoogle Scholar
  19. Bell, F. P., and Schwartz, C. J., 1971, Exchangeability of cholesterol between swine serum lipoproteins and erythrocytes in vitro, Biochim. Biophys. Acta 231:553.PubMedGoogle Scholar
  20. Bloj, B., and Zilversmit, D. B., 1976, Asymmetry and transposition rates of phosphatidylcholine in rat erythrocyte ghosts, Biochemistry 15:1277.PubMedCrossRefGoogle Scholar
  21. Bloj, B., and Zilversmit, D. B., 1977a, Rat liver proteins capable of transferring phosphatidylethanolamine: Purification and transfer activity for other phospholipids and cholesterol, J. Biol. Chem. 252:1613.PubMedGoogle Scholar
  22. Bloj, B., and Zilversmit, D. B., 1977b, Transposition and distribution of cholesterol in rat erythrocytes, Proc. Soc. Exp. Biol. Med. 156:539.PubMedGoogle Scholar
  23. Bloj, B., and Zilversmit, D. B., 1981, Accelerated transfer of neutral glycosphingolipids and ganglioside GM1 by a purified lipid transfer protein, J. Biol. Chem. 256:5988.PubMedGoogle Scholar
  24. Bondjers, G., Wiklund, O., Olofsson, S.-O., Gustaf son, A., and Björkerud, S. U., 1981, Relationship between high-density lipoproteins and atherosclerosis, in: High Density Lipoproteins (C. E. Day, ed.), pp. 463–503, Dekker, New York.Google Scholar
  25. Brotherus, J. R., Griffith, O. H., Brotherus, M. O., Jost, P. C., Silvius, J. R., and Hokin, L. E., 1981, Lipid-protein multiple binding equilibria in membranes, Biochemistry 20:5261.PubMedCrossRefGoogle Scholar
  26. Brown, M. S., Kovanen, P. T., and Goldstein, J. L., 1980, Evolution of the LDL receptor concept: From cultured cells to intact animals, Ann. N.Y. Acad. Sci. 348:48.PubMedCrossRefGoogle Scholar
  27. Chajek, T., Aron, L., and Fielding, C. J., 1980, Interaction of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in the transport of cholesteryl ester into sphingomyelin liposomes, Biochemistry 19:3673.PubMedCrossRefGoogle Scholar
  28. Chapman, D., 1975, Lipid dynamics in cell membranes, in: Cell Membranes: Biochemistry, Cell Biology and Pathology (G. Weissmann and R. Clairborne, eds.), pp. 13–22, HP Publishing, New York.Google Scholar
  29. Chapman, D., Gomez-Fernandez, J. C, and Goni, F. M., 1979, Intrinsic protein-lipid interactions: Physical and biochemical evidence, FEBS Lett. 98:211.PubMedCrossRefGoogle Scholar
  30. Charlton, S. C., Olson, J. S., Hong, K.-Y., Pownall, H. J., Louie, D. D., and Smith L. C., 1976, Stopped flow kinetics of pyrene transfer between high density lipoproteins, J. Biol. Chem. 251:7952.PubMedGoogle Scholar
  31. Charlton, S. C., Hong, K.-Y., and Smith, L. C, 1978, Kinetics of rac-l-oleyl-2-[4-(3-pyr-enyl)butanoyl] glycerol transfer between high density lipoproteins, Biochemistry 17:3304.PubMedCrossRefGoogle Scholar
  32. Chevallier, F., d’Hollander, F., and Vaughan, M., 1971, Plasma cholesterol ester formation in situ, and their transfer into the rat tissues in vivo, Biochim. Biophys. Acta 248:524.Google Scholar
  33. Christians son, A., Gutman, H., Wieslander, Å., and Lindblom, G., 1981, Effects of anesthetics on water permeability and lipid metabolism in Acholeplasma laidlawii membranes, Biochim. Biophys. Acta 645:24.CrossRefGoogle Scholar
  34. Cohen, P., and Derksen, A., 1969, Comparison of phospholipid and fatty acid composition of human erythrocytes and platelets, Br. J. Haematol. 17:359.PubMedCrossRefGoogle Scholar
  35. Comte, J., Maisterrena, B., and Gautheron, D. C, 1976, Lipid composition and protein profiles of outer and inner membranes from pig heart mitochondria and comparison with microsomes. Biochim. Biophys. Acta 419:271.PubMedCrossRefGoogle Scholar
  36. Cooper, R. A., 1969, Anemia with spur cells: A red cell defect acquired in the serum and modified in the circulation, J. Clin. Invest. 48:1820.PubMedCrossRefGoogle Scholar
  37. Cooper, R. A., 1977, Abnormalities of cell-membrane fluidity in the pathogenesis of disease, N.Engl. J. Med. 297:371.PubMedCrossRefGoogle Scholar
  38. Cooper, R. A., 1978, Influence of increased membrane cholesterol on membrane fluidity and cell function in human red blood cells, J. Supramol. Struct. 8:413.PubMedCrossRefGoogle Scholar
  39. Cooper, R. A., Durocher, J. R., and Leslie, M. H., 1977, Decreased fluidity of red cell membrane lipids in abetalipoproteinemia, J. Clin. Invest. 60:115.PubMedCrossRefGoogle Scholar
  40. Cornell, R. B., and Horwitz, A. F., 1980, Apparent coordination of the biosynthesis of lipids in cultured cells: Its relationship to the regulation of the membrane sterol: phospholipid ratio and cell cycling, J. Cell Biol. 86:810.PubMedCrossRefGoogle Scholar
  41. Crain, R. C, and Zilversmit, D. B., 1980, Two nonspecific phospholipid exchange proteins from beef liver. I. Purification and characterization, Biochemistry 19:1433.PubMedCrossRefGoogle Scholar
  42. Crain, R. C, and Zilversmit, D. B., 1981, Lipid dependence of glucose-6-phosphate phospho-hydrolase: A study with purified phospholipid transfer proteins and phosphatidylinositol-specific phospholipase C, Biochemistry 20:5320.PubMedCrossRefGoogle Scholar
  43. Cullis, P. R., and de Kruijff, B., 1979, Lipid polymorphism and the functional roles of lipids in biological membranes, Biochim. Biophys. Acta 559:399.PubMedGoogle Scholar
  44. Dahlquist, F. W., Muchmore, D. C., Davis, J. H., and Bloom, M., 1977, Deuterium magnetic resonance studies of the interaction of lipids with membrane proteins, Proc. Natl. Acad. Sci. USA 74:5435.PubMedCrossRefGoogle Scholar
  45. de Kruyff, B., van Dijck, P. W. M., Goldbach, R. W., Demel, R. A., and van Deenen, L. L. M., 1973, Influence of fatty acid and sterol composition on the lipid phase transition and activity of membrane-bound enzymes in Acholeplasma laidlawii, Biochim. Biophys. Acta 330:269.PubMedCrossRefGoogle Scholar
  46. De Paillerets, C., Gallay, J., Vincent, M., Rogard, M., and Alfsen, A., 1981, Membrane lipid dynamics and enzymic activity in bovine adrenal cortex microsomes, Biochim. Biophys. Acta 664:134.Google Scholar
  47. Dickens, B. F., and Thompson, G. A., Jr., 1981, Rapid membrane response during low-temperature acclimation: Correlation of early changes in the physical properties and lipid composition of Tetrahymena microsomal membranes, Biochim. Biophys. Acta 644:211.PubMedCrossRefGoogle Scholar
  48. Dnistrian, A. M., Barclay, M., Terebus-Kekish, O., Archibald, F. M., and Morris, H. P., 1979, Serum lipoproteins in rats bearing Morris hepatomas of different degrees of differentiation, Cancer Biochem. Biophys. 3:81.PubMedGoogle Scholar
  49. Doody, M. C., Pownall, H. J., Kao, Y. J., and Smith, L. C, 1980, Mechanism and kinetics of transfer of a fluorescent fatty acid between single-walled phosphatidylcholine vesicles, Biochemistry 19:108.PubMedCrossRefGoogle Scholar
  50. Douady, D., Grosbois, M., Guerbette, F., and Kader, J.-C, 1982, Purification of a basic phospholipid transfer protein from maize seedlings, Biochim. Biophys. Acta 710:143.Google Scholar
  51. Duckwitz-Peterlein, G., Eilenberger, G., and Overath, P., 1977, Phospholipid exchange between bilayer membranes, Biochim. Biophys. Acta 469:311.PubMedCrossRefGoogle Scholar
  52. Edidin, M., 1974, Rotational and translational diffusion in membranes, Annu. Rev. Biophys. Bioeng. 3:179.PubMedCrossRefGoogle Scholar
  53. Farias, R. N., Bloj, B., Morero, R. D., Sineriz, F., and Trucco, R. E., 1975, Regulation of allosteric membrane-bound enzymes through changes in membrane lipid composition, Biochim. Biophys. Acta 415:231.PubMedGoogle Scholar
  54. Fishman, P. H., and Brady, R. O., 1976, Biosynthesis and function of gangliosides, Science 194:906.PubMedCrossRefGoogle Scholar
  55. Fleischer, S. F., Bock, H.-G., and Gazzotti, P., 1974, Studies of phospholipid-protein interaction in d-β-hydroxybutyrate dehydrogenase, a lecithin requiring enzyme, in: Membrane Proteins in Transport and Phosphorylation (G. F. Azzone, M. E. Klingenberg, E. Quagliariello, and N. Siliprandi, eds.), pp. 125–136, North-Holland, Amsterdam.Google Scholar
  56. Galla, H.-J., Theilen, U., and Hartmann, W., 1979, Transversal mobility in bilayer membrane vesicles: Use of pyrene lecithin as optical probe, Chem. Phys. Lipids 23:239.CrossRefGoogle Scholar
  57. Gazzotti, P., Bock, H.-G., and Fleischer, S., 1975, Interaction of d-β-hydroxybutyrate apodehydrogenase with phospholipids, J. Biol. Chem. 250:5782.PubMedGoogle Scholar
  58. Gibbons, G. F., Mitropoulos, K. A., and Myant, N. B., 1982, Biochemistry of Cholesterol, pp. 327–333, Elsevier, Amsterdam.Google Scholar
  59. Giraud, F., and Claret, M., 1979, A study of cholesterol transfers between erythrocytes and lipid vesicles, FEBS Lett 103:186.CrossRefGoogle Scholar
  60. Glomset, J. A., 1973, The metabolic role of lecithin: cholesterol acyltransferase: Perspectives from pathology, Adv. Lipid Res. 11:1.Google Scholar
  61. Glomset, J. A., 1979, Lecithin: cholesterol acyltransferase: An exercise in comparative biology, Prog. Biochem. Pharmacol. 15:41.PubMedGoogle Scholar
  62. Gordon, L. M., Sauerheber, R. D., Esgate, J. A., Dipple, I., Marchmont, R. J., and Houslay, M. D., 1980, The increase in bilayer fluidity of fat liver plasma membranes achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes, J. Biol. Chem. 255:4519.PubMedGoogle Scholar
  63. Grandison, A. S., and Green, C., 1979, Transfer of cholesterol between different regions of the rat hepatocyte surface membrane, Int. J. Biochem. 10:623.PubMedCrossRefGoogle Scholar
  64. Hanna, S., Kawamoto, R., McNamee, M., and Baskin, R. J., 1981, Enzymatic activity of dystrophic chicken sarcoplasmic reticulum, Biochim. Biophys. Acta 643:41.PubMedCrossRefGoogle Scholar
  65. Haran, N., and Shporer, M., 1977, Proton magnetic resonance study of cholesterol transfer between egg yolk lecithin vesicles, Biochim. Biophys. Acta 465:11.PubMedCrossRefGoogle Scholar
  66. Hearing, V. J., and Nicholson, J. M., 1979, Abnormal protein synthesis in malignant melanoma cells, Cancer Biochem. Biophys. 4:59.PubMedGoogle Scholar
  67. Holtzman, E., Gronowicz, G., Mercurio, A., and Masur, S. K., 1979, Notes on the heterogeneity, circulation and modifications of membranes with emphasis on secretory cells, photoreceptors, and the toad bladder, Biomembranes 10:77.PubMedGoogle Scholar
  68. Hostetler, K. Y., Zenner, B. D., and Morris, H. P., 1979, Phospholipid content of mitochondrial and microsomal membranes from Morris hepatomas of varying growth rates, Cancer Res. 39:2978.PubMedGoogle Scholar
  69. Inbar, M., and Shinitzky, M., 1974, Cholesterol as a bioregulator in the development and inhibition of leukemia, Proc. Natl. Acad. Sci. USA 71:4229.PubMedCrossRefGoogle Scholar
  70. Jonas, A., and Maine, G. T., 1979, Kinetics and mechanism of phosphatidylcholine and cholesterol exchange between single bilayer vesicles and bovine high-density lipoprotein, Biochemistry 18:1722.PubMedCrossRefGoogle Scholar
  71. Jost, P. C., Griffith, O. H., Capaldi, R. A., and Vanderkooi, G., 1973, Evidence for boundary lipid in membranes, Proc. Natl. Acad. Sci. USA 70:480.PubMedCrossRefGoogle Scholar
  72. Kantor, H. L., and Prestegard, J. H., 1975, Fusion of fatty acid containing lecithin vesicles, Biochemistry 14:1790.PubMedCrossRefGoogle Scholar
  73. Kao, Y. J., Charlton, S. C, and Smith, L. C, 1977, Cholesterol transfer to high density lipoproteins, Fed. Proc. Fed. Am. Soc. Exp. Biol. 56:936.Google Scholar
  74. Kasai, R., Kitajima, Y., Martin, C. E., Nozawa, Y., Skriver, L., and Thompson, G. A., Jr., 1976, Molecular control of membrane properties during temperature acclimation: Membrane fluidity regulation of fatty acid desaturase action, Biochemistry 15:5228.PubMedCrossRefGoogle Scholar
  75. Kirby, C. J., and Green, C, 1977, Transmembrane migration (flip-flop) of cholesterol in eryth-rocyte membranes, Biochem. J. 168:575.PubMedGoogle Scholar
  76. Kovatchev, S., Vaz, W. L. C, and Eibl, H., 1981, Lipid dependence of the membrane-bound d-lactate dehydrogenase of Escherichia coli, J. Biol. Chem. 256:10369.PubMedGoogle Scholar
  77. Kramer, R. M., Hasselbach, H.-J., and Semenza, G., 1981, Rapid transmembrane movement of phosphatidylcholine in small unilamellar lipid vesicles formed by detergent removal, Biochim. Biophys. ACta 643:233.PubMedCrossRefGoogle Scholar
  78. Krebs, J. J. R., Hauser, H., and Carafoli, E., 1979, Asymmetric distribution of phospholipids in the inner membrane of beef heart mitochondria, J. Biol. Chem. 254:5308.PubMedGoogle Scholar
  79. Kremer, J. M. H., Kops-Werkhoven, M. M., Pathmamanoharan, C., Gijzeman, O. L. J., and Wiersema, P. H., 1977, Phase diagrams and the kinetics of phospholipid exchange for vesicles of different composition and radius, Biochim. Biophys. Acta 471:177.PubMedCrossRefGoogle Scholar
  80. Lenard, J., and Rothman, J. E., 1976, Transbilayer distribution and movement of cholesterol and phospholipid in the membrane of influenza virus, Proc. Natl. Acad. Sci. USA 73:391.PubMedCrossRefGoogle Scholar
  81. Levietes, B. B., 1980, The role of lipid metabolism in neoplastic differentiation, J. Theor. Biol. 85:523.CrossRefGoogle Scholar
  82. McBride, J. A., and Jacob, H. S., 1970, Abnormal kinetics of red cell membrane cholesterol in acanthocytes: Studies in genetic and experimental abetalipoproteinemia, Br. J. Haematol. 18:383.PubMedCrossRefGoogle Scholar
  83. Machida, K., and Ohnishi, S.-L, 1978, A spin-label study of phosphatidylcholine exchange protein: Regulation of the activity of phosphatidylserine and calcium ion, Biochim. Biophys. Acta 507:156.PubMedCrossRefGoogle Scholar
  84. McLean, L. R., and Phillips, M. C, 1981, Mechanism of cholesterol and phosphatidylcholine exchange or transfer between unilamellar vesicles, Biochemistry 20:2893.PubMedCrossRefGoogle Scholar
  85. McMurchie, E. J., and Raison, J. K., 1979, Membrane lipid fluidity and its effect on the activation energy of membrane-associated enzymes, Biochim. Biophys. Acta 554:364.PubMedCrossRefGoogle Scholar
  86. Madden, T. D., Vigo, C., Bruckdorfer, K. R., and Chapman, D., 1980, The incorporation of cholesterol into inner mitochondrial membranes and its effect on lipid phase transition, Biochim. Biophys. ACta 599:528.PubMedCrossRefGoogle Scholar
  87. Marčelja, S., 1976, Lipid-mediated protein interaction in membranes, Biochim. Biophys. Acta 455:1.PubMedCrossRefGoogle Scholar
  88. Martin, C. E., Hiramitsu, K., Kitajima, Y., Nozawa, Y., Skriver, L., and Thompson, G. A., Jr., 1976, Molecular control of membrane properties during temperature acclimation: Fatty acid desaturase regulation of membrane fluidity in acclimating Tetrahymena cells, Biochemistry 15:5218.PubMedCrossRefGoogle Scholar
  89. Martin, F. J., and MacDonald, R. C, 1976, Phospholipid exchange between bilayer membrane vesicles, Biochemistry 15:321.PubMedCrossRefGoogle Scholar
  90. Miyahara, M., Nishihara, Y., Morimazoto, Y., and Utsumi, K., 1981a, Lipid-dependent interaction of d-β-hydroxybutyrate dehydrogenase with cellular membranes, Biochim. Biophys. Acta 641:232.PubMedCrossRefGoogle Scholar
  91. Miyahara, M., Utsumi, K., and Deamer, D. W., 1981b, Selective interaction of d-β-hydroxybutyrate dehydrogenase with intracellular membrane, Biochim. Biophys. Acta 641:222.PubMedCrossRefGoogle Scholar
  92. Morton, R. E., and Zilversmit, D. B., 1981, The separation of apolipoprotein D from cholesteryl ester transfer protein, Biochim. Biophys. Acta 663:350.PubMedGoogle Scholar
  93. Nakagawa, Y., Inoue, K., and Nojima, S., 1979, Transfer of cholesterol between liposomal vesicles, Biochim. Biophys. Acta 553:307.PubMedCrossRefGoogle Scholar
  94. Nandini-Kishore, S. G., Kitajima, Y., and Thompson, G. A., Jr., 1977, Membrane fluidizing effects of the general anesthetic methoxyflurane elicit an acclimation response in Tetrahymena, Biochim. Biophys. Acta 471:157.PubMedCrossRefGoogle Scholar
  95. Nichols, J. W., and Pagano, R. E., 1981, Kinetics of soluble lipid monomer diffusion between vesicles, Biochemistry 20:2783.PubMedCrossRefGoogle Scholar
  96. Nicoll, A., Miller, N. E., and Lewis, B., 1980, High-density lipoprotein metabolism, Adv. Lipid Res. 17:53.PubMedGoogle Scholar
  97. Ogiso, T., Iwaki, M., and Mori, K., 1981, Fluidity of human erythrocyte membrane and effect of chlorpromazine on fluidity and phase separation of membrane, Biochim. Biophys. Acta 649:325.PubMedCrossRefGoogle Scholar
  98. Op den Kamp, J. A. F., 1979, Lipid asymmetry in membranes, Annu. Rev. Biochem. 48:47.PubMedCrossRefGoogle Scholar
  99. Owen, J. S., Hutton, R. A., Day, R. C., Bruckdorfer, K. R., and McIntyre, N., 1981, Platelet lipid composition and platelet aggregation in human liver disease, J. Lipid Res. 22:423.PubMedGoogle Scholar
  100. Papahadjopoulos, D., Poste, G., and Schaeffer, B. E., 1973, Fusion of mammalian cells by unilamellar lipid vesicles: Influence of lipid surface charge, fluidity and cholesterol, Biochim. Biophys. Acta 323:23.PubMedCrossRefGoogle Scholar
  101. Pattnaik, N. M., and Zilversmit, D. B., 1979, Interaction of cholesteryl ester exchange protein with human plasma lipoproteins and phospholipid vesicles, J. Biol. Chem. 254:2782.PubMedGoogle Scholar
  102. Pattnaik, N. M., Montes, A., Hughes, L. B., and Zilversmit, D. B., 1978, Cholesteryl ester exchange protein in human plasma: Isolation and characterization, Biochim. Biophys. Acta 530:428.PubMedGoogle Scholar
  103. Patzer, E. J., Shaw, J. M., Moore, N. F., Thompson, T. E., and Wagner, R. R., 1978, Trans-membrane movement and distribution of cholesterol in membrane vesicular stomatitis virus, Biochemistry 17:4192.PubMedCrossRefGoogle Scholar
  104. Philippot, J. R., Cooper, A. G., and Wallach, D. F. H., 1977, Regulation of cholesterol biosynthesis by normal and leukemic (L2C) guinea pig lymphocytes, Proc. Natl. Acad. Sci. USA 74:956.PubMedCrossRefGoogle Scholar
  105. Phillips, M. C., McLean, L. R., Stoudt, G. W., and Rothblat, G. H., 1980, Mechanism of cholesterol efflux from cells, Atherosclerosis 36:409.CrossRefGoogle Scholar
  106. Poon, R., Richards, J. M., and Clark, W. R., 1981, The relationship between plasma membrane lipid composition and physical-chemical properties. II. Effect of phospholipid fatty acid modulation on plasma membrane physical properties and enzymatic activities, Biochim. Biophys. Acta 649:58.PubMedCrossRefGoogle Scholar
  107. Poorthuis, B. J. H. M., Van Der Krift, T. P., Teerlink, T., Akeroyd, R., Hostetler, K. Y., and Wirtz, K. W. A., 1980, Phospholipid transfer activities in Morris hepatomas and the specific contribution of the phosphatidylcholine exchange protein, Biochim. Biophys. Acta 600:376.PubMedCrossRefGoogle Scholar
  108. Post, M., Batenburg, J. J., Schuurmans, E. A. J. M., and Van Golde, L. M. G., 1980, Phos-pholipid transfer activity in type II cells isolated from adult rat lung, Biochim. Biophys. Acta 620:317.PubMedGoogle Scholar
  109. Poste, G., and Allison, A. C, 1973, Membrane fusion, Biochim. Biophys. Acta 300:421.PubMedGoogle Scholar
  110. Poznansky, M. J., and Lange, Y., 1978, Transbilayer movement of cholesterol in phospholipid vesicles under equilibrium and non equilibrium conditions, Biochim. Biophys. Acta 506:256.PubMedCrossRefGoogle Scholar
  111. Prestegard, J. H., and Fellmeth, B., 1974, Fusion of dimyristoyllecithin vesicles as studied by proton magnetic resonance spectroscopy, Biochemistry 13:1122.PubMedCrossRefGoogle Scholar
  112. Reed, C. F., Murphy, M., and Roberts, G., 1968, Phospholipid exchange between plasma and erythrocytes in man and the dog, J. Clin. Invest. 47:749.PubMedCrossRefGoogle Scholar
  113. Renooij, W., van Golde, L. M. G., Zwaal, R. F. A., and van Deenen, L. L. M., 1976, Topological asymmetry of phospholipid metabolism in rat erythrocyte membranes: Evidence for flip-flop of lecithin, Eur. J. Biochem. 61:53.PubMedCrossRefGoogle Scholar
  114. Roseman, M. A., and Thompson, T. E., 1980, Mechanism of the spontaneous transfer of phos-pholipids between bilayers, Biochemistry 19:439.PubMedCrossRefGoogle Scholar
  115. Rothblat, G. H., Arbogast, L. Y., Kritchevsky, D., and Naftulin, M., 1976, Cholesteryl ester metabolism in tissue culture cells. II. Source of accumulated esterified cholesterol in Fu5AH rat hepatoma cells, Lipids 11:97.PubMedCrossRefGoogle Scholar
  116. Rothblat, G. H., Arbogast, L. Y., and Ray, E. K., 1978, Stimulation of esterified cholesterol accumulation in tissue culture cells exposed to high density lipoproteins enriched in free cholesterol, J. Lipid Res. 19:350.PubMedGoogle Scholar
  117. Rothman, J. E., Tsai, D. K., Dawidowicz, E. A., and Lenard, J., 1976, Transbilayer phospholipid asymmetry and its maintenance in the membrane of influenza virus, Biochemistry 15:2361.PubMedCrossRefGoogle Scholar
  118. Rottem, S., 1981, Cholesterol is required to prevent crystallization of Mycoplasma arginini phospholipids at physiological temperature, FEBS Lett. 133:161.PubMedCrossRefGoogle Scholar
  119. Rottem, S., Shinar, D., and Bittman, R., 1981, Symmetrical distribution and rapid transbilayer movement of cholesterol in Mycoplasma gallisepticum membranes, Biochim. Biophys. Acta 649:572.PubMedCrossRefGoogle Scholar
  120. Sandermann, H., Jr., 1978, Regulation of membrane enzymes by lipids, Biochim. Biophys. Acta 515:209.PubMedGoogle Scholar
  121. Sanslone, W. R., Bertrand, H. A., Yu, B. P., and Masoro, E. J., 1972, Lipid composition of sarcotubular membranes, J. Cell Physiol. 79:97.PubMedCrossRefGoogle Scholar
  122. Shattil, S. J., Anaya-Galindo, R., Bennett, J., Colman, R. W., and Cooper, R. A., 1975, Platelet hypersensitivity induced by cholesterol incorporation, J. Clin. Invest. 55:636.PubMedCrossRefGoogle Scholar
  123. Shattil, S. J., Bennett, J. S., Colman, R. W., and Cooper, R. A., 1977, Abnormalities of cholesterol-phospholipid composition in platelets and low density lipoproteins of human hy-perbetalipoproteinemia, J. Lab. Clin. Med. 80:341.Google Scholar
  124. Shinitzky, M., and Inbar, M., 1974, Difference in microviscosity induced by different cholesterol levels in the surface membrane lipid layer of normal lymphocytes and malignant lymphoma cells, J. Mol. Biol. 85:603.PubMedCrossRefGoogle Scholar
  125. Sinha, A. K., Shattil, S. J., and Colman, R. W., 1977, Cyclic AMP metabolism in cholesterol-rich platelets, J. Biol. Chem. 252:3310.PubMedGoogle Scholar
  126. Smith, L. C, and Scow, R. O., 1979, Chylomicrons: Mechanism of transfer of lipolytic products to cells, Prog. Biochem. Pharmacol. 15:109.PubMedGoogle Scholar
  127. Sokoloff, L., and Rothblat, G. H., 1972, Regulation of sterol synthesis in L cells: Steady state transitional responses, Biochim. Biophys. Acta 280:172.PubMedGoogle Scholar
  128. Solaini, G., and Bertoli, E., 1981, Lipid dynamics and lipid-protein interaction in isolated beef-heart mitochondrial ATPase complex, FEBS Lett. 132:127.PubMedCrossRefGoogle Scholar
  129. Steele, J. A., Poznansky, M. J., Eaton, D. C, and Brodwick, M. S., 1981, Lipid vesicle-mediated alterations of membrane cholesterol levels: Effects of Na+ and K+ currents in squid axon, J. Membr. Biol. 63:191.PubMedCrossRefGoogle Scholar
  130. Stein, O., Vanderhoek, J., and Stein, Y., 1976, Cholesterol content and sterol synthesis in human skin fibroblasts and rat aortic smooth muscle cells exposed to lipoprotein-depleted serum and high density apolipoprotein/phospholipid mixtures, Biochim. Biophys. Acta 431:347.PubMedGoogle Scholar
  131. Stier, A., and Sackmann, E., 1973, Spin labels as enzyme substrates: Heterogenous lipid distribution in liver microsomal membranes, Biochim. Biophys. Acta 311:400.PubMedCrossRefGoogle Scholar
  132. Stuhne-Sekalec, L., and Stanacev, N. Z., 1980, Mitochondrial importation of lipids and lipon-ucleotides from microsomes independent of and facilitated by purified cytosol proteins, Can. J. Biochem. 58:1082.PubMedCrossRefGoogle Scholar
  133. Träuble, H., and Overath, P., 1973, The structure of Escherichia coli membranes studied by fluorescence measurements of lipid phase transitions, Biochim. Biophys. Acta 307:491.PubMedCrossRefGoogle Scholar
  134. Van Meer, G., Lange, L. G., Op den Kamp, J. A. F., and van Deenen, L. L. M., 1980a, Protein-stimulated exchange of phosphatidylcholine between intact erythrocytes and various membrane systems, Biochim. Biophys. Acta 598:173.PubMedCrossRefGoogle Scholar
  135. Van Meer, G., Poorthuis, B. J. H. M., Wirtz, K. W. A., Op den Kamp, J. A. F., and van Deenen, L. L. M., 1980b, Transbilayer distribution and mobility of phospholipid in intact erythrocyte membranes: A study with phosphatidylcholine exchange protein, Eur. J. Biochem. 103:283.PubMedCrossRefGoogle Scholar
  136. Wallach, D. F. H., 1975, Membrane Molecular Biology in Neoplastic Cells, pp. 217–241, Elsevier, Amsterdam.Google Scholar
  137. Walter, V. P., Kloppel, T. M., Deimling, I. G., and Morré, D. J., 1980, Alterations in neutral glycosphingolipids from transplantable hepatomas and in sera of rats bearing transplantable hepatomas, Cancer Biochem. Biophys. 4:145.PubMedGoogle Scholar
  138. Warren, G. B., Houslay, M. D., Metcalfe, J. C, and Birdsall, N. J. M., 1975, Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein, Nature (London) 255:684.CrossRefGoogle Scholar
  139. Wirtz, K. W. A., 1974, Transfer of phospholipids between membranes, Biochim. Biophys. Acta 344:95.PubMedGoogle Scholar
  140. Yamauchi, T., Ohki, K., Maruyama, H., and Nozawa, Y., 1981, Thermal adaptation of Tetrahymena membranes with special reference to mitochondria: Role of cardiolipin in fluidity of mitochondrial membranes, Biochim. Biophys. Acta 649:385.PubMedCrossRefGoogle Scholar
  141. Zambrano, F., Fleischer, S., and Fleischer, B., 1975, Lipid composition of the Golgi apparatus of rat kidney and liver in comparison with other subcellular organelles, Biochim. Biophys. Acta 380:357.PubMedGoogle Scholar
  142. Zilversmit, D. B., and Hughes, M. E., 1976, Phospholipid exchange between membranes, in: Methods in Membrane Biology (E. D. Korn, ed.), Vol. 7, pp. 211–259, Plenum Press, New York.Google Scholar
  143. Zilversmit, D. B., Hughes, L. B., and Balmer, J., 1975, Stimulation of cholesterol ester exchange by lipoprotein-free rabbit plasma, Biochim. Biophys. Acta 409:393.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Frank P. Bell
    • 1
  1. 1.Atherosclerosis-Thrombosis ResearchThe Upjohn CompanyKalamazooUSA

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