Regulation of Hepatic Phospholipid N-Methylation

  • Björn Åkesson
Part of the Biomembranes book series (B, volume 12)


The biosynthesis of the major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), operates via several pathways. The interplay between different reactions is further complicated by the fact that molecular species within each phospholipid class are formed via different routes in a characteristic manner (Åkesson and Sundler, 1977). For several reasons this biosynthetic machinery has been studied extensively in liver. This organ produces phospholipids for the bile and several lipo-protein classes. Thus, the liver has an active phospholipid turnover in a wide variety of pathways. Phospholipid N-methylation was first demonstrated in rat liver by Bremer et al. (1960). Björnstad and Bremer (1966) found that phospholipid methylation was of quantitative importance in liver (see Fig. 1) but not in other organs. The interesting studies of Hirata and Axelrod (1980) have recently stimulated further research on this reaction also in ex-trahepatic tissues.


Phospholipid Composition Methylation Rate Arachidonic Acid Release Choline Deficiency Methionine Adenosyltransferase 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Björn Åkesson
    • 1
  1. 1.Department of Clinical ChemistryUniversity HospitalLundSweden

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