The Micronucleus Test as an Indicator of Mutagenic Exposure

  • Robert R. Racine
  • Bernhard E. Matter
Part of the Topics in Chemical Mutagenesis book series (TCM, volume 2)


The widespread demand for protection against chemical substances in the environment that may damage genetic material emphasizes the need for reliable and comprehensive assay systems for the detection of genotoxic effects. Such effects can be classified in three broad categories, namely (1) gene and point mutations, (2) chromosome mutations, and (3) genome mutations. It is well known that in humans these effects may lead to severe clinical disorders that may be transmissible to future generations if they occur in the germ line. A number of chemical substances that could cause such adverse effects in humans have already been identified by means of experimental work with biological assay systems.


Chromosome Aberration Styrene Oxide Chemical Mutagen Micronucleus Test Bone Marrow Smear 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Robert R. Racine
    • 1
  • Bernhard E. Matter
    • 1
  1. 1.Preclinical Research, ToxicologySandoz Ltd.BasleSwitzerland

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