Role of Macrophages in T Cell Activation
There is now general agreement that the induction of any immune response is dependent on macrophages (MØ) or MØ-like cells which act as antigen presenting cells. However, beside MØ, other cells which are not considered to belong to the MØ lineage are also involved in the induction of at least some immune processes. Thus, these ‘inducer’ cells are heterogeneous and the use of the term ‘accessory cells’ (AC) or ‘antigen presenting cells’ (APC) instead of MØ seems to be more appropriate to describe these cells. However, as a lot of the evidence for antigen presentation has been obtained by studying classical MØ, the term ‘MØ’ will be further used, keeping in mind that the functional activities described will not necessarily be restricted to this particular cell type.
KeywordsSpleen Cell Tumour Line Accessory Cell Peritoneal Exudate Immune Spleen Cell
antigen presenting cell
genetically related MØ factor
I region associated
Ia-associated antigen complex
major histocompatibility complex
- P cells
peritoneal exudate cells
T helper cells
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