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Role of Macrophages in T Cell Activation

  • P. Erb
  • G. Ramila
  • A. Stern
  • I. Sklenar

Abstract

There is now general agreement that the induction of any immune response is dependent on macrophages (MØ) or MØ-like cells which act as antigen presenting cells. However, beside MØ, other cells which are not considered to belong to the MØ lineage are also involved in the induction of at least some immune processes. Thus, these ‘inducer’ cells are heterogeneous and the use of the term ‘accessory cells’ (AC) or ‘antigen presenting cells’ (APC) instead of MØ seems to be more appropriate to describe these cells. However, as a lot of the evidence for antigen presentation has been obtained by studying classical MØ, the term ‘MØ’ will be further used, keeping in mind that the functional activities described will not necessarily be restricted to this particular cell type.

Keywords

Spleen Cell Tumour Line Accessory Cell Peritoneal Exudate Immune Spleen Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AC

accessory cells

APC

antigen presenting cell

DC

dentric cells

GRF

genetically related MØ factor

Ia

I region associated

IAC

Ia-associated antigen complex

MHC

major histocompatibility complex

macrophage(s)

P cells

persisting cells

PEC

perito­neal exudate cells

Thc

T helper cells

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • P. Erb
    • 1
  • G. Ramila
    • 1
  • A. Stern
    • 1
  • I. Sklenar
    • 1
  1. 1.Institute for MicrobiologyUniversity of BaselBaselSwitzerland

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