Advertisement

Leukotrienes and Lipid Factors: Mediators and Modulators of the Inflammatory Reactions

  • W. König
  • K. D. Bremm
  • K. Theobald
  • Ph. Pfeiffer
  • B. Szperalski
  • A. Bohn
  • P. Borgeat
  • B. Spur
  • A. E. G. Crea
  • G. Falsone

Abstract

In the past years the immunological and chemical analysis of mediators involved in inflammation has led to a remarkable change in the understanding of allergic and inflammatory reactions. The discovery of the IgE-immunoglobulin as the antibody molecule inducing immediate type hypersensitivity reactions as well as the molecular analysis of the anaphylatoxins (C3a, C5a) emphasized the major role of the mast cells in allergic and inflammatory disease processes. Mast cell activation by immunological and non immunological mechanisms led to the release of preformed and newly generated mediators (1). Among those were products previously called “slow reacting substance” (SRS), lipid chemotactic factor (ECF) and platelet activating factor (PAF=AGEPC). Only recently the chemical structures of these molecules have been established (2–5). Evidence was also presented in the seventies that in addition to mast cells secondary cells of inflammation such as neutrophils, mononuclear cells and macrophages released mediators which previously had been solely attributed to the mast cell alone (6,7). Thus, the concept of the interdependency of various cells in inflammatory reactions initiated by low molecular weight mediators was established.

Keywords

Mast Cell Arachidonic Acid Chemotactic Activity Opsonized Zymosan Induce Histamine Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    König, W., Pfeiffer, P., Szperalski, B. and Bohn, A., in “ Behring Institute Mitteilungen”, 68: 30–50 (1981).Google Scholar
  2. 2.
    Borgeat, P. and Samuelsson, B., J. Biol. Chem. 254: 7865–7869 (1979).PubMedGoogle Scholar
  3. 3.
    Benveniste, J., Camussi, J. and Polonsky, J., Allergy 12: 138–142 (1977).Google Scholar
  4. 4.
    Corey, E.J., Clark, D.A., Goto, G., Marfat, A., Mioskowski, C., Samuelsson, B. and Hammarström, S., J. Am. Chem. Soc. 102: 1436–1439 (1980).CrossRefGoogle Scholar
  5. 5.
    Demopoulos, C.A., Pinckard, R.N. and Hanahan, D.J., J. Biol. Chem. 254: 9355–9358 (1979).PubMedGoogle Scholar
  6. 6.
    Czarnetzki, B.M., König, W. and Lichtenstein, L.M., J. Immunol. 117: 229–234 (1976).PubMedGoogle Scholar
  7. 7.
    König, W., Czarnetzki, B.M. and Lichtenstein, L.M., J. Immunol. 117: 235–246 (1976).PubMedGoogle Scholar
  8. 8.
    Samuelsson, B., “Trends in Pharmacological Sciences”, pp. 227–230 (1980).Google Scholar
  9. 9.
    König, W., Frickhofen, N. and Tesch, H., Immunology 36: 733–742 (1979).PubMedGoogle Scholar
  10. 10.
    Frickhofen, N. and König, W., Immunology 37: 111–122 (1979).PubMedGoogle Scholar
  11. 11.
    König, W., Tesch, H. and Frickhofen, N., Eur. J. Immunol. 8: 434–437 (1978).PubMedCrossRefGoogle Scholar
  12. 12.
    Tesch, H. and König, W., Scand. J. Immunol. 11: 409–418 (1980).PubMedCrossRefGoogle Scholar
  13. 13.
    König, W., Kunau, H.W. and Borgeat, P., Abcdefg, in: “Leukotrienes and other Lipoxygenase Products”, Samuelsson, B. and Paoletti, R. (eds), Vol.9, pp. 301–314 Raven Press, New York (1982).Google Scholar
  14. 14.
    Ford-Hutchinson, A.W., J. Royal Soc. Med. 74: 831–833 (1981).Google Scholar
  15. 15.
    Goetzl, E.J. and Pickett, W.C., J. Exp. Med., 153: 482–487 (1981).PubMedCrossRefGoogle Scholar
  16. 16.
    Jörg, A., Henderson, W.R., Murphy, R.C. and Klebanoff, J., J. Exp. Med. 155: 390–402 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • W. König
    • 1
  • K. D. Bremm
    • 1
  • K. Theobald
    • 1
  • Ph. Pfeiffer
    • 1
  • B. Szperalski
    • 1
  • A. Bohn
    • 1
  • P. Borgeat
    • 2
  • B. Spur
    • 3
  • A. E. G. Crea
    • 3
  • G. Falsone
    • 3
  1. 1.Lehrstuhl Med. Mikrobiologie und ImmunologieRuhr-UniversitätBochumGermany
  2. 2.Département d’Endocrinologie MoléculaireLe Centre de L-Université LavalSteFoyeCanada
  3. 3.Institut für organische ChemieUniversität DüsseldorfGermany

Personalised recommendations