Leukotrienes and Lipid Factors: Mediators and Modulators of the Inflammatory Reactions
In the past years the immunological and chemical analysis of mediators involved in inflammation has led to a remarkable change in the understanding of allergic and inflammatory reactions. The discovery of the IgE-immunoglobulin as the antibody molecule inducing immediate type hypersensitivity reactions as well as the molecular analysis of the anaphylatoxins (C3a, C5a) emphasized the major role of the mast cells in allergic and inflammatory disease processes. Mast cell activation by immunological and non immunological mechanisms led to the release of preformed and newly generated mediators (1). Among those were products previously called “slow reacting substance” (SRS), lipid chemotactic factor (ECF) and platelet activating factor (PAF=AGEPC). Only recently the chemical structures of these molecules have been established (2–5). Evidence was also presented in the seventies that in addition to mast cells secondary cells of inflammation such as neutrophils, mononuclear cells and macrophages released mediators which previously had been solely attributed to the mast cell alone (6,7). Thus, the concept of the interdependency of various cells in inflammatory reactions initiated by low molecular weight mediators was established.
KeywordsMast Cell Arachidonic Acid Chemotactic Activity Opsonized Zymosan Induce Histamine Release
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