Human IgG Short-Term Sensitizing Anaphylactic Antibody: Differences in Properties from Those of IgG4
Two anaphylactic antibodies are found in human sera. IgE, the classical reaginic antibody which occurs in very small amounts, which passively sensitizes human skin in vivo for four weeks or longer, and the passive sensitizing property is susceptible to heating at 56°C or treatment with reducing chemicals. The other antibody with anaphylactic or very similar properties is part of the total IgG, and at present is known as IgG S-TS, or short-term sensitizing, because it sensitizes human or monkey skin for 2 to 4 hours only. The passive sensitizing property of IgG S-TS resists heating at 56°C and resists treatment with reducing chemicals.
KeywordsFood Allergy Histamine Release Monkey Skin Human Basophil Passive Cutaneous Anaphylaxis
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