Early Detection of Autoimmune Endocrine Disorders

  • Deborah Doniach
  • Gian Franco Bottazzo


Organ specific autoimmunity (AI) has been demonstrated in all the defined endocrine organs except the pineal gland and is now being studied in the paracrine systems of the gastrointestinal tract and the hypothalamus. The ‘autoimmune’ endocrine disorders are characterized by the presence of antibodies in the patients’ serum which may be detected years before the onset of clinical symptoms and are useful monitors of the lesions well before hormonal deficiencies can be measured by metabolic tests. In the case of ‘stimulating’ antibodies that produce hormone excess, and hormone receptor antibodies generally, the situation is far more complex.


Primary Biliary Cirrhosis Diabetes Insipidus Pernicious Anaemia Acanthosis Nigricans Toxic Nodular Goitre 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Deborah Doniach
    • 1
  • Gian Franco Bottazzo
    • 1
  1. 1.The Department of ImmunologyMiddlesex Hospital Medical SchoolLondonUK

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