Some Aspects of T Cell Regulation in Autoimmune Diseases

  • Rudy E. Ballieux
  • Cobi J. Heijnen


There is ample evidence that the immune response in man is regulated, although not exclusively, by T cells which have the capacity to induce, amplify or suppress the reactivity of the immune system. Analogous to the situation in the mouse, these various regulatory T cell functions are exerted by lymphocytes residing in distinct T cell subpopulations (1,2). These subsets can be recognized by distinct surface markers such as receptors for Fc fragments of different immunoglobulin isotypes (3) and cell surface structures defined by monoclonal antibodies (4).


Juvenile Rheumatoid Arthritis Cell Circuit Effector Cell Activity Target Culture Helper Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Gershon, R.K., J. Allergy Clin. Immunol. 66: 18 (1980).PubMedCrossRefGoogle Scholar
  2. 2.
    Fauci, A.S., Ballieux, R.E. (eds.), “Human B cell function: activation and immunoregulation,” Raven Press, New York (1982).Google Scholar
  3. 3.
    Heijnen, C.J., UytdeHaag, F., Gmelig-Meyling, F.H.J., Ballieux, R.E., Cell. Immunol. 43: 282 (1979).PubMedCrossRefGoogle Scholar
  4. 4.
    Reinherz, E.L., Schlossman, S.F., Immunol. Today 2: 69 (1981).CrossRefGoogle Scholar
  5. 5.
    Fauci, A.S., Ballieux, R.E. (eds.), Arntibody production in man: in vitro synthesis and clinical implications,“ Academic Press, New York (1979).Google Scholar
  6. 6.
    Möller, G., Immunol. Rev. 45: 3 (1979).CrossRefGoogle Scholar
  7. 7.
    Lane, H.C., Volkman, D.J., Whalen, G., Fauci, A.S., J. Exp. Med. 154: 1043 (1981).PubMedCrossRefGoogle Scholar
  8. 8.
    Misiti, J., Waldmann, T.A., J. Exp. Med. 154: 1069 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    UytdeHaag, F., Heijnen, C.J., Pot, K.H., Ballieux, R.E., J. Immunol. 126: 503 (1981).PubMedGoogle Scholar
  10. 10.
    Reinherz, E.L., Moretta, L., Roper, M., Breard, J.M., Mingari, M.C., Cooper, M.D., Schlossman, S.F., J. Exp. Med. 151: 969 (1980).PubMedCrossRefGoogle Scholar
  11. 11.
    Heijnen, C.J., Pot, K.H., Ballieux, R.E., Eur. J. Immunol. (in press).Google Scholar
  12. 12.
    Heijnen, C.J., UytdeHaag, F., Pot, C.H., Ballieux, R.E., Nature 280: 589 (1979).PubMedCrossRefGoogle Scholar
  13. 13.
    Corte G, Mingari, M.C., Moretta, A., Damiani, G., Moretta, L., Bargellesi, A., J. Immunol. 128: 16 (1982).PubMedGoogle Scholar
  14. 14.
    Leeuwen, A. van, Festenstein, H., Rood, J. J. van, J. Exp. Med. 152: 235s (1980).Google Scholar
  15. 15.
    Reinherz, E.L., Strelkauskas, A.J., O’Brien, C., Schlossman S.F., J. Immunol. 123: 83 (1980).Google Scholar
  16. 16.
    Palacios, R., Alarcon-Segovia, D., Llorente, L., Ruiz-Arguelles, A., Diaz-Jouanen, E., Immunology 42: 127 (1981).PubMedGoogle Scholar
  17. 17.
    Heijnen, C.J., UytdeHaag, F., Ballieux, R.E., Immunopathol. 3: 63 (1980).Google Scholar
  18. 18.
    Gladman, D., Keystone, E., Urowitz, M., Cane, D., Poplonski, L., Clin. Exp. Immunol. 40: 77 (1980).PubMedGoogle Scholar
  19. 19.
    Heijnen, C.J., Pot, K.H., Kater, L., Kluin-Nelemans, H.C., UytdeHaag, F., Ballieux, R.E., Clin. Exp. Immunol. 47: 359 (1982).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Rudy E. Ballieux
    • 1
    • 2
  • Cobi J. Heijnen
    • 2
  1. 1.Departments of Clinical ImmunologyUniversity HospitalUtrechtThe Netherlands
  2. 2.University Children’s Hospital“Het Wilhelmina Kinderziekenhuis”UtrechtThe Netherlands

Personalised recommendations