T Cell Subset Responses in Varied Immunodeficiency Syndromes

  • F. Caballero
  • P. Kohler
  • A. R. Hayward


Patients with common varied immunodeficiency syndromes (CVID) are heterogeneous as regards the number and function of T cells in their blood (1,2). A minority of CVID patients has strong suppressor activity in in vitro functional tests and many have a relative increase of cells in blood which bear the suppressor-cytotoxic phenotype, T8+ (3). A primary increase in suppressor cells may contribute to hypogammaglobulinemia in some patients with thymoma (4) but in the majority of CVID patients it is unclear whether the increase in T8+ cells is primary or whether it results from antigen stimulation. We therefore examined the possibility that antien stimulation might maintain increased numbers or proportions of T8+ cells in CVID patients by determining the phenotype of their T cell blasts in cultures stimulated with tetanus toxoid. The rationale for this approach derives from the observation that soluble antigens normally elicit proliferation by T4+ cells while cell-associated antigens (such as allogenic cells) elicit responses by both T4+ and T8+ cells.


Suppressor Cell Cell Blast Tetanus Toxoid Tritiated Thymidine Common Varied Immunodeficiency 
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  1. 1.
    Webster, A.D.B. and Asherson, G.L., Clin. Exp. Immunol. 18: 449 (1974).Google Scholar
  2. 2.
    Geha, R.S., Schneeberger, E., Mesler, E. and Rosen, F.S., New En. J. Med. 291: 1 (1974).CrossRefGoogle Scholar
  3. 3.
    Reinherz, E.L., Cooper, M.D., Schlossman, S.F. and Rosen, R.S., J. Clin. Invest. 68: 699 (1981).PubMedCrossRefGoogle Scholar
  4. 4.
    Hayward, A.R. and Kurnick, J.T., J. Immunol. 126: 50 (1981).PubMedGoogle Scholar
  5. 5.
    Hayward, A.R., Paolucci, P., Webster, A.D.B. and Kohler, P.F., Clin. Exp. Immunol. (1982) (in press).Google Scholar
  6. 6.
    Challacombe, S.J. and Tomasi, T.B., J. Exp. Med. 152:1459 (1980).Google Scholar
  7. 7.
    Cunningham-Rundles, C., Brandeis, W.E., Good, R.A. and Day, N.K., J. Clin. Invest. 64:272 (1979).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • F. Caballero
    • 1
  • P. Kohler
    • 1
  • A. R. Hayward
    • 1
  1. 1.Departments of Pediatrics and MedicineUniversity of Colorado Health Sciences CenterDenverUSA

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