T Cell Subset Responses in Varied Immunodeficiency Syndromes
Patients with common varied immunodeficiency syndromes (CVID) are heterogeneous as regards the number and function of T cells in their blood (1,2). A minority of CVID patients has strong suppressor activity in in vitro functional tests and many have a relative increase of cells in blood which bear the suppressor-cytotoxic phenotype, T8+ (3). A primary increase in suppressor cells may contribute to hypogammaglobulinemia in some patients with thymoma (4) but in the majority of CVID patients it is unclear whether the increase in T8+ cells is primary or whether it results from antigen stimulation. We therefore examined the possibility that antien stimulation might maintain increased numbers or proportions of T8+ cells in CVID patients by determining the phenotype of their T cell blasts in cultures stimulated with tetanus toxoid. The rationale for this approach derives from the observation that soluble antigens normally elicit proliferation by T4+ cells while cell-associated antigens (such as allogenic cells) elicit responses by both T4+ and T8+ cells.
KeywordsSuppressor Cell Cell Blast Tetanus Toxoid Tritiated Thymidine Common Varied Immunodeficiency
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