Antibody Producing Human-Human Hybridomas

  • L. Olsson


Monoclonal hybridoma antibody technology has already proven to be highly useful in a variety of biological areas (1–3). Only a few papers have reported on production of human monoclonal hybridoma antibodies as produced by human-human hybridomas (4–7) and none of these reports have dealt with the technical details of the human-human hybridoma system. We here report on technical difficulties and improvements of the human-human hybridoma system.


Spleen Cell Fusion Partner Mitogen Stimulation Active Cell Cycle Pokeweed Mitogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kennett, R.H., McKearn, T.J., Bechtol, K.B. (eds.), Plenum Press, New York, p.1 (1980).Google Scholar
  2. 2.
    Hammerling, G.J., Hammerling, U., Kearney, J.F. (eds.), “Monoclonal antibodies and T-cell hybridomas”, Elsevier, Amsterdam, p.1 (1981).Google Scholar
  3. 3.
    McMichael, A. and Fabre, J. (eds.), Academic Press, New York, p.1 (1982).Google Scholar
  4. 4.
    Olsson, L. and Kaplan, H.S., Proc. Natl. Acad. Sci. (USA), 77: 5429 (1980).CrossRefGoogle Scholar
  5. 5.
    Croce, C.A., Linnenbach, A., Hall, W., Steplewski, Z., Korpowski, H., Nature 288: 488 (1980).PubMedCrossRefGoogle Scholar
  6. 6.
    Sikora, K., Anderson, T., Phillips, J., Watson, J.V., Lancet 1: 2 (1982).Google Scholar
  7. 7.
    Shoenfeld, Y., Hsu-Lin, S.C., Gabriels, J.E., Silberstein, L.E., Furie, B.C., Furie, B., Stoller, B.D., Schwartz, R.S., J. Clin. Invest. 70: 205 (1982).PubMedCrossRefGoogle Scholar
  8. 8.
    Oi, V.T., Jones, P.P., Goding, J.W., Herzenberg, L.A., Curr. Top. Microbiol. Immunol. 81: 115 (1978).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • L. Olsson
    • 1
  1. 1.Medical Department AState University HospitalCopenhagenDenmark

Personalised recommendations