Immunomodulation in Tumor Systems

  • A. Matter


This brief article is mainly concerned with the problems of validity and reproducibility of animal tumor models when testing defined pharmacological compounds. The questions that arise are:
  • Is there an immune response with cytostatic or cytotoxic potential against a tumor?

  • Is there a simple parameter with which to measure overall immune anti-tumor activity?

  • Can this parameter be manipulated at will and reproducibly by reference drugs?

  • And is the activity of a test drug against the tumor itself clearly separable from its effect on the immune system?


Line Source Tumor System Mixed Lymphocyte Culture Adjuvant Activity Syngeneic Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Matter
    • 1
    • 2
  1. 1.Immunology Laboratories FranceSchering Plough CorporationDardillyFrance
  2. 2.Pharma-Research DivisionF. Hoffmann-La RocheBaselSwitzerland

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