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Regression of Coronary Atherosclerosis in Man

  • N. B. Myant
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 168)

Abstract

There is abundant evidence that it is possible to bring about some degree of regression of experimentally-induced atherosclerosis of the coronary arteries in animals (see Armstrong, 1976, for review). Much of the published work on regression of atherosclerosis induced in animals by diets, with or without concomitant injury to the arterial walls, has been concerned with the reversal of lesions that bear more resemblance to fatty streaks than to the fully developed lesions associated with ischaemic heart disease in man. However, there can be no doubt that lesions in the coronary arteries, closely resembling the naturally-occurring human atheromatous lesion, can be induced in monkeys by the prolonged feeding of cholesterol-rich diets, and that withdrawal of the dietary regimen may result in partial regression of the lesions, with widening of the lumen, loss of intimal lipid and, possibly, a decrease in the amount of collagen in the arterial wall (Armstrong et al., 1970; Vesselinovitch et al., 1976; Stary et al., 1977). A survey of the relevant literature suggests that the time taken to bring about regression of experimentally-induced atherosclerosis by withdrawal of the atherogenic regimen is at least as long as the time taken to induce the atherosclerosis (Vesselinovitch and Wissler, 1977), and that in order to induce significant regression in monkeys the plasma cholesterol concentration must be reduced to less than 200 mg/100 ml throughout the regression period (Bond et al., 1977).

Keywords

Aortic Root Plasma Exchange Plasma Cholesterol Coronary Atherosclerosis Plasma Cholesterol Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • N. B. Myant
    • 1
  1. 1.Medical Research Council Lipid Metabolism UnitHammersmith HospitalLondonUK

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