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The Healing and Scarring of Atheroma pp 37–50Cite as

Ultrastructural Features of Healing and Scarring of Experimental Atheroma

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 168))

Abstract

Most of the available morphological data on regression of experimental atherosclerotic lesions of the arterial wall (rev. by Armstrong, 1976; Wissler, 1977; Weber, 1978; Stary, 1979) have been documented in animal models (pigs, dogs, monkeys) and are being investigated in man. It is chiefly from studies on monkeys that our knowledge has been substantiated. Wissler et al. (1975), Vesselinovitch et al. (1976) have demonstrated substantially reduced percentage of grossly involved aortic intima in monkeys withdrawn from atherogenic diets. The regressing lesions contain very little intracellular and extracellular lipid and show no evidence of a necrotic center (features that are usually prominent in advanced atherosclerotic lesions), contain a reduced number of cells (Stary, 1974; 1977) and are covered by an endothelial layer of regenerating cells (Weber et al., 1977) (Fig. 1–2).

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  1. Center of Research on Atherosclerosis - Institute of Pathological Anatomy, University of Siena, Italy

    Giorgio Weber

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  1. Giorgio Weber
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  1. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Moshe Wolman

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© 1984 Plenum Press, New York

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Weber, G. (1984). Ultrastructural Features of Healing and Scarring of Experimental Atheroma. In: Wolman, M. (eds) The Healing and Scarring of Atheroma. Advances in Experimental Medicine and Biology, vol 168. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4646-3_3

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  • DOI: https://doi.org/10.1007/978-1-4684-4646-3_3

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