Macrophage Activation in the Prevention or Regression of Atherosclerosis

  • Edith Gaton
  • Moshe Wolman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 168)


Studies of our group, first presented at a meeting of the Israel Atherosclerosis Society in 1973, indicated that atheromatosis might be the result of imbalance between the amounts of lipids absorbed in — or synthesized by the intima and the amounts removed or metabolized. According to this notion the fate of intimal smooth muscle cells, whether they will or will not be transformed into foam cells and eventually burst with formation of a poltaceous lipoproteic mass, depends on the relationship between the lipid input and output processes. Absorption of lipids from the medium and synthesis are included here under the heading “input”, while export of lipids from the tissues to the circulation as well as catabolism are included under “output”.


Cholesteryl Ester Foam Cell Cocoa Butter Macrophage Activation Atherogenic Diet 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Edith Gaton
    • 1
  • Moshe Wolman
    • 1
  1. 1.Department of PathologyTel Aviv University, Sackler School of MedicineTel AvivIsrael

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