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Pathological Principles Involved in Regression of Atherosclerosis

  • C. W. M. Adams
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 168)

Summary

The view is advanced that regression of atherosclerosis depends on normal pathological principles, namely the process of organization. On account of the hypoxic milieu of the arterial wall and lack of capillary ingrowths into it, the hypoxia-resistant arterial smooth muscle cell subserves the functions of both phagocyte and fibroblast in organization. The proliferation of smooth muscle in atherosclerosis is, thus, attributed to a variant of a basic pathological mechanism, and does not require more a complex explanation, such as the action of a somatotropin, mitogen or mutagen. Moderate dilatation of the arterial wall, caused by the basic pathological mechanisms of either atrophy or hypertrophy would, within definite limits, offset inward encroachment by atherosclerosis and, thus, could constitute another type of regression, or at least a failure of lumen calibre to get worse.

Keywords

Arterial Wall Atherosclerotic Lesion Mononuclear Phagocyte Arterial Smooth Muscle Cell Aortic Atherosclerosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adams, C. W. M. 1964, Arteriosclerosis in man, other mammals and birds. Biol. Revs. 39, 372.CrossRefGoogle Scholar
  2. Adams, C.W.M. and Bayliss, O.B., 1976a, Detection of macrophages in atherosclerotic lesions with cytochrome oxidase. Brit. J. Exp. Pathol., 57, 30–36.Google Scholar
  3. Adams, C.W.M. and Bayliss, O.B. 1976b. Succinic dehydrogenase and cytochrome oxidase in arterial venous and other smooth muscle. Atherosclerosis, 23, 367–370.CrossRefGoogle Scholar
  4. Adams, C.W.M. and Morgan, R.S., 1977, Regression of atheroma in the rabbit. Atherosclerosis, 28, 399–404.PubMedCrossRefGoogle Scholar
  5. Adams, C.W.M., Bayliss, O.B. and Turner, D.R. 1975, Phagocytes, lipid-removal and regression of atheroma. J. Pathol., 116, 225–238.PubMedCrossRefGoogle Scholar
  6. Anitschkow, N., 1933, Experimental arteriosclerosis in animals, in: “Arteriosclerosis” ed. by E.V. Cowdry, Macmillan, London and New York.Google Scholar
  7. Armstrong, J.L. and Megan, M.B., 1972, Lipid depletion in atheromatous coronary arteries in rhesus monkeys after regression diets. Circulation 30, 675–680.CrossRefGoogle Scholar
  8. Aschoff, L. 1924, Lectures in Pathology. Hoeber, New York, pp 131–153.Google Scholar
  9. Baranowski, A., Adams, C.W.M., Bayliss High, O.B. and Bowyer, D., 1982, Connective tissue responses to oxysterols. Atherosclerosis, in press.Google Scholar
  10. Bayliss High, O.B., and Adams, C.W.M., I98O, The role of macrophages and giant cells in advanced human atherosclerosis. Atherosclerosis, 36, 441–447.Google Scholar
  11. Benditt, E.P. 1974, Evidence for the monoclonal origin of human atherosclerotic plaques and some implications. Circulation, 50, 650.PubMedCrossRefGoogle Scholar
  12. Cohnheim, J. 1889, Inflammation, in: “Lectures on General Pathology”. The New Sydenham Society, London. Vol. 1. pp 242–382.Google Scholar
  13. Duguid, J.B., 1926, Atheroma of the aorta. J. Path., Bact. 29, 371.Google Scholar
  14. Duguid, J.B., 1948, Thrombosis as a factor in the pathogenesis of aortic atherosclerosis. J. Path. Bact. 58, 207.Google Scholar
  15. Gaton, E. and Wolman, M., 1977, The role of smooth muscle cells and haematogenous macrophages in atheroma. J. Pathol., 123, 123–128.PubMedCrossRefGoogle Scholar
  16. Geer, J.C. and Haust, M.D., 1972, Smooth muscle cells in atherosclerosis. Monographs on Atherosclerosis, No. 2. Karger, Basel, p. 39.Google Scholar
  17. Gilmann, T., 1964, A plea for arterial biology as a basis for understanding arterial disease, in: “Biological Aspects of Occlusive Vascular Disease.” Ed. by D.G. Chalmers and G.A. Gresham, Cambridge University Press, London, pp 3–23.Google Scholar
  18. Harrison, C.V. and Wood, P., 1949, Hypertensive and ischaemic heart disease: a comparative and pathological study. Brit. Heart J. 11: 205.PubMedCrossRefGoogle Scholar
  19. Heughen, C., Niinikoski, J. and Hunt, T.K., 1973, Oxygen tensions in lesions of experimental atherosclerosis in rabbits. Atherosclerosis, 17, 361.CrossRefGoogle Scholar
  20. Kirk, J.E. and Lausen, T.J.S., 1955, Diffusion coefficients of various solutes for human aortic tissue, with special reference to variation in tissue permeability with age. J. Gerontol., 10, 288–302.PubMedCrossRefGoogle Scholar
  21. Lehninger, A.L., 1959, The metabolism of the arterial wall, in:— “The Arterial Wall” ed. by A. I. Lansing, Williams, and Wilkins, Baltimore, pp 220–246.Google Scholar
  22. McCullagh, K.G. and Balian, G., 1975, Collagen characterisation and cell transformation in human atherosclerosis. Nature (Lond.), 258, 73CrossRefGoogle Scholar
  23. Morgan, A.D. 1956, The Pathogensis of Coronary Occlusion, Blackwell, Oxford, pp 68–117Google Scholar
  24. Radhakrishnamurthy, B., Eggen, D.A., Kokatnur, Y., Jirge, S., Strong, J.P. and Berenson, G.S., 1975, Composition of connective tissue in aortas from rhesus monkeys during regression of diet induced fatty streaks. Lab. Invest. 33, 136–146.PubMedGoogle Scholar
  25. Ross, R., Glomset, J., Kariya, B. and Harker, L., 1974, A platelet dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Nat. Acad. Sci., 71, 1207–1210.PubMedCrossRefGoogle Scholar
  26. Ross, R. and Klebanoff, S.J., 1971, The smooth muscle cell. I. In vivo synthesis of connective tissue proteins. J. Cell. Biol. 50, 159.Google Scholar
  27. Vesselinovitch, D., Wissler, R.W., Hughes, R. and Borensztajn, J., 1976, Révisai of advanced atherosclerosis in rhesus monkeys. Part 1. Light microscopic studies. Atherosclerosis, 239 155–176CrossRefGoogle Scholar
  28. Virchow, R. von., 1856, Gesammette Abhandlungen zur Wissenschaftlichen Medicin, Berlin, Muller, pp 458–521.Google Scholar
  29. Wilson, J., Adams, C.W.M. and Brander, W.L., 1978, The antiocclusive effect of coronary dilatation with age. Atherosclerosis, 29, 503.PubMedCrossRefGoogle Scholar
  30. Woerner, C.A., 1959, Vasa vasorum of arteries, their demonstration and distribution, in: “The Arterial Wall”, ed. by A.I. Lansing, Williams and Wilkins, Baltimore, pp 1–14.Google Scholar
  31. Wolinsky, H. and Glagov, S., 1967, Nature of species differences in the medial distribution of aortic vasa vasorum in mammals. Circulât. Res. 20, 490Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • C. W. M. Adams
    • 1
  1. 1.Department of PathologyGuy’s Hospital Medical SchoolLondonUK

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