Evolution and Enzymes

  • J. Lawrence Fox


The molecular weight for a given enzyme from presumed primitive microbes to “simple” eukaryotes and on to higher eukaryotes is seen to increase in a consistent fashion for a variety of enzymes (Dayhoff, 1972; Klotz et al., 1975; Bisswanger and Schmincke-Ott, 1980; Fox and Lynen, 1980). The significance of this progression is not obvious, but can be used to increase our understanding of the evolutionary process (De Ley and Kerstens, 1975; Williams and Fox, 1974, 1980; Fox and Williams, 1978; Schwartz and Dayhoff, 1978). The evolution of organisms is intimately tied to the evolution of its enzymes. We will develop a scenario for the evolution of enzymic systems which defines a general path for organismal evolution in this paper.


Individual Amino Acid Alpha Helix Raman Resonance Continual Change Punctuate Equilibrium 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. Lawrence Fox
    • 1
  1. 1.Department of Molecular BiologyAbbott LaboratoriesNorth ChicagoUSA

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