The Genetic Anticode: The Role of Thermal Proteinoids in the Development of an Hypothesis

  • James C. LaceyJr.
  • Dail W. MullinsJr.


I had the good opportunity to work as a postdoctoral fellow with Sid Fox for two years (1969 and 1970). It was during this period that my already existing interest in, and fascination with, the origin of the genetic code became firmly embedded in my soul. The permanancy was established by two aspect of my experience at Miami that were due, in the main, to Sid Fox’s exceptional scientific intuition. On the one hand, Sid was convinced that an understanding of the origin of the genetic code necessitated the use of a dynamic system which is synthesizing peptides. He and his coworkers were studying peptide formation from aminoacyl adenylates when I arrived there (Krampitz and Fox, 1969), and I became a part of that effort (Nakashima et al., 1970). Furthermore, as still another application of thermal proteinoids, Sid had already begun studying the question of their interaction with polynucleotides and had established that about 15 mole % lysine in the proteinoid was required to initiate their binding to polynucleotides (Waehneldt and Fox, 1968), and that lysine-rich and arginine-rich proteinoids had different preference among the homopolynucleotides (Yuki and Fox, 1969).


Genetic Code Hydrophilic Amino Acid Anticodon Loop Selective Affinity Codon Assignment 
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  1. Barrell, B. G., Bankier, A. T., and Drouin, J., 1979, Nature, 282: 189.PubMedCrossRefGoogle Scholar
  2. Crick, F. H. C., 1968, J. Mol. Biol., 38:367.PubMedCrossRefGoogle Scholar
  3. Dunnill, P., 1966, Nature, 210:268.CrossRefGoogle Scholar
  4. Fox, S. W., Nakashima, T., and Lacey, Jr., J. C., 1971, in: “Nucleic Acid Protein Interactions,” D. W. Ribbon, and J. F. Woessner, eds., p. 113, North-Holland, Amsterdam.Google Scholar
  5. Garel, J. P., Filliol, D., AND Mandel, P., 1973, J. Chromat., 78: 381.Google Scholar
  6. Jungck, J. R., 1978, J. Mol. Evol., 11:211.PubMedCrossRefGoogle Scholar
  7. Khaled, H. A., Mullins, Jr., D. W., and Lacey, Jr., J. C., 1983, J. Mol. Evol. (in press).Google Scholar
  8. Krampitz, G., and Fox, S. W., 1969, Proc. Nat. Acad. Sci. U.S., 62:399.CrossRefGoogle Scholar
  9. Lacey, Jr., J. C., and Pruitt, K. M., 1969, Nature, 223:799.PubMedCrossRefGoogle Scholar
  10. Lacey, Jr., J. C., Stephens, D. P., and Fox, S. W., 1979, Biosystems, 11:9.PubMedCrossRefGoogle Scholar
  11. Lacey, Jr., J. C., and Weber, A. L., 1976, in: “Protein Structure and Evolution,” L. Fox, Z. Deyl, and A. Blazej, eds., p. 213, Marcel-Dekker, Basal.Google Scholar
  12. Lacey, Jr., J. C., and Weber, A. L., 1977, Precamb. Res., 5:219.CrossRefGoogle Scholar
  13. Lacey, Jr., J. C., and Mullins, Jr., D. W., 1981, in: “Origins of Life,” Y. Wolman, ed., p. 447, D. Reidel, Dordrecht, Holland.CrossRefGoogle Scholar
  14. Macino, G., Coruzzi, G., Nobrega, F. G., Li, M., and Tzagoloff, A., 1979, Proc. Nat. Acad. Sci. U.S., 76:3784.CrossRefGoogle Scholar
  15. Nagyvary, J., and Fendler, J., 1974, Origins Life, 5:357.CrossRefGoogle Scholar
  16. Nakashima, T., Lacey, Jr., J. C., Jungck, J. R., and Fox, S. W., 1970, Naturwiss., 57:67.PubMedCrossRefGoogle Scholar
  17. Ralph, R. K., 1968, Biochem. Biophys. Res. Comm., 33:213.PubMedCrossRefGoogle Scholar
  18. Reuben, H., and Polk, F., 1980, J. Mol. Evol., 15:103.PubMedCrossRefGoogle Scholar
  19. Waehneldt, T. B., and Fox, S. W., 1968, Biochim. Biophys. Acta, 160:239.PubMedGoogle Scholar
  20. Weber, A. L., and Lacey, Jr., J. C., 1978, J. Mol. Evol., 11:199.PubMedCrossRefGoogle Scholar
  21. Woese, C., 1967, “The Genetic Code,” Harper and Row, New York.Google Scholar
  22. Woese, C. R., Dugre, P. H., Saxinger, W. C., and Dugre, S. A., 1966, Proc. Nat. Acad. Sci. U.S., 55:966.CrossRefGoogle Scholar
  23. Ycas, M., 1969, “The Biological Code,” North-Holland, Amsterdam.Google Scholar
  24. Yuki, A., and Fox, S. W., 1969, Biochem. Biophys. Res. Comm., 36:657.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • James C. LaceyJr.
    • 1
  • Dail W. MullinsJr.
    • 1
  1. 1.Department of BiochemistryUniversity of AlabamaBirminghamUSA

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