Pyrophosphate as a Possible Precursor of ATP

  • Fritz Lipmann


I am very pleased to participate in honoring Dr. Sidney Fox in this anniversary volume. I am ever so grateful that he invited me to the memorable 1965 conference on the Origins of Prebiological Systems. I proposed there the search for biochemical fossils in present-day organisms (Lipmann, 1965). As a rare example, I mentioned then the pyrophosphate (PPi) linked reaction of Siu and Wood (1962):
$$oxaloacetate+P{{P}_{i}}\to \ phosphoenolpyruvate+C{{O}_{2}}+{{P}_{i}}$$
where PPi appears to replace the ATP. It was proposed that PPi may be considered the precursor of ATP in evolution. Such a possibility has recently been re-emphasized in various laboratories, particularly by Harland Wood et al. (1977) and by R. Reeves (1982). Reeves has worked predominantly with entamoeba histolytica, a parasitic anaerobe and emphasizes a PPi-linked phosphorylation in glycolysis in the case of 6-P fructophosphokinase. Included here are other interesting reactions such as phosphorylation of serine by PPi.


Propionic Acid Fatty Acid Synthesis Entamoeba Histolytica Antibiotic Peptide Amino Acid Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Fritz Lipmann
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

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