On Proteinoid Structure

  • Paul Melius
  • Vasilios Nicolaou


The structure of proteinoids should be of special interest to the peptide chemist and those studying the prebiotic chemical evolution preceding the origin of life. Fox and his colleagues (1980) have experimentally discovered a number of interesting properties of the proteinoids (thermal polyamino acids) such as their ability to form microspheres (protocells) in aqueous solutions and specific catalytic activities which would be necessary to form polymers. A number of parameters can influence the polymerization of the amino acids such as: reactivities, steric constraints of the amino acid side chains as well as the growing polymer chain, stability of intermediates and products, hydrogen-bonding interactions and amino acid composition of the polymerization mixture. A great deal of information is necessary on structure of the polymers in order to understand their ability to coalesce into microspheres and ability to act as specific catalyts.


Amino Acid Composition Polymerization Mixture Thermal Polymerization Cyclic Dipeptide Activate Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Asquith, R. S., Otterburn, M. S., Buchanan, J. H., Cole, M.,Fletcher, J. C., and Gardner, K. L., 1970, Biochim. Biophys. Acta, 221: 342.PubMedGoogle Scholar
  2. Banda, P. W., and Ponnamperuma, C., 1971, Space Life Sciences, 3: 54.PubMedCrossRefGoogle Scholar
  3. Dose, K., and Zaki, L., 1971, Z. Naturforsch., 26b: 144.Google Scholar
  4. Fox, S. W., and Harada, K., 1960, J. Am. Chem. Soc., 82: 3745.CrossRefGoogle Scholar
  5. Fox, S. W., 1968, Encycl. Polym. Sci. Technol., 9: 294.Google Scholar
  6. Fox, S. W., 1976, in: “Protein Structure and Function,” J. L. Fox, L. Deyl, and A. Blazej, eds., p. 125, Marcel Dekker, New York.Google Scholar
  7. Fox, S. W., and Nakashima, T., 1980, BioSystems, 12: 155.PubMedCrossRefGoogle Scholar
  8. Fox, S. W., 1980, Naturwiss., 67: 576.PubMedCrossRefGoogle Scholar
  9. Hartmann, J., Brand, M. C., and Dose, K., 1981, BioSystems, 13: 141.PubMedCrossRefGoogle Scholar
  10. Heinrich, M. R., Rohlfing, D. L., and Bugna, E., 1969, Arch. Biochem. Biophys., 130: 441.PubMedCrossRefGoogle Scholar
  11. Hubbard, W. L., 1973, “Thermal peptides: An attempt to remove the pyrrolidone carboxyl residues from the N-terminal ends,” M.S. thesis, Auburn University, Auburn, Alabama.Google Scholar
  12. Inoue, C., and Yamada, T., 1979, “A synthetic method for pyroglutamyl peptides,” Jpn. Kokai Tokkyo Koho, 79: 19, 967.Google Scholar
  13. Johnstone, R. A. W., and Povall, T. Jeffrey, 1975, J. Chem. Soc. Perkin Trans., 1: 1297.CrossRefGoogle Scholar
  14. Katchalski, A., and Ailam, G., 1967, Biochim. Biophys. Acta., 140: 1.Google Scholar
  15. Krampitz, G., Baars-Diehl, S., Haas, W., and Nakashima, T., 1968, Experientia, 24: 140.PubMedCrossRefGoogle Scholar
  16. Krampitz, G., and Fox, S. W., 1969, Proc. Nat. Acad. Sci. U.S., 62: 399.CrossRefGoogle Scholar
  17. Melius, P., and Sheng, J.Y.P., 1975, Bioorg. Chem., 4: 385.CrossRefGoogle Scholar
  18. Melius, P., 1977, in: “Bioorganic Chemistry, Vol. III, Macro-andMultimolecular Systems,” E. van Tamelin, ed., Academic Press, New York.Google Scholar
  19. Melius, P., 1982, BioSystems, 15: 275.PubMedCrossRefGoogle Scholar
  20. Melius, P., 1983, unpublished work.Google Scholar
  21. Miller, S. L., 1955, J. Am. Chem. Soc., 77: 2351.CrossRefGoogle Scholar
  22. Nakashima, T., Lacey, J. C., Jungck, J., and Fox, S. W., 1970, Naturwiss., 57: 1.CrossRefGoogle Scholar
  23. Nakashima, T., Jungck, J. R., Fox, S. W., Lederer, E., and Das, B. C., 1977, Int. J. Quant. Chem., QBS4: 65.Google Scholar
  24. Phillips, R. D., and Melius, P., 1974, Int. J. Peptide Protein Res., 6: 309.CrossRefGoogle Scholar
  25. Ponnamperuma, C., and Peterson, E., 1965, Science, 147: 1572.PubMedCrossRefGoogle Scholar
  26. Sheng, J. Y. P., 1974, “Studies on thermal polymerization of six amino acids,” M.S. thesis, Auburn University, Auburn, Alabama.Google Scholar
  27. Steinman, G., and Cole, M. N., 1967, Proc. Nat. Acad. Sci. U.S., 58: 735.CrossRefGoogle Scholar
  28. Weber, A. L., and Orgel, L. E., 1979, J. Mol. Evol., 13: 185.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Paul Melius
    • 1
  • Vasilios Nicolaou
    • 1
  1. 1.Department of ChemistryAuburn UniversityAuburnUSA

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