Receptor Defects in Genetic Forms of Extreme Insulin Resistance

  • Simeon I. Taylor
Part of the Biochemical Endocrinology book series (BIOEND, volume 1)


The responsiveness of target cells to insulin is carefully regulated under many physiological conditions (Grunberger et al., 1983; Olefsky, 1981). Thus, two mechanisms work in concert to regulate the biological effect of insulin upon target cells: (1) changes in circulating levels of insulin in plasma; and (2) alterations in the sensitivity of the target cell to insulin. Abnormalities in the regulation of insulin sensitivity contribute importantly to the pathophysiology of many disease states: e.g., obesity, type II diabetes (non-insulin-dependent diabetes mellitus), acromegaly, and Cushing’s syndrome.


Insulin Resistance Insulin Receptor Apparent Molecular Weight Insulin Binding Subunit Structure 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Simeon I. Taylor
    • 1
    • 2
  1. 1.Diabetes BranchNational Institute of Arthritis, Diabetes, Digestive and Kidney DiseasesUSA
  2. 2.National Institutes of HealthBethesdaUSA

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