Regulation of Gonadotropin Receptors and Steroidogenic Responses in Cultured Leydig Tumor Cells

  • Mario Ascoli
  • Dale A. Freeman
Part of the Biochemical Endocrinology book series (BIOEND, volume 1)


The regulation of cell surface receptors for polypeptide hormones is now recognized as an important mechanism in the regulation of target cell responsiveness (reviewed by Hazum, 1982; King and Cuatrecasas, 1981; Kaplan, 1981; Tell et al., 1978; Catt et al., 1979). Thus, changes in target cell responsiveness associated with several physiological or pathological conditions can be explained in terms of changes in the number of surface receptors (Olefsky and Ciaraldi, 1981; Archer et al., 1975; Purvis et al., 1978; Brief el et al., 1982; Klemcke and Bartke, 1981).


Granulosa Cell Leydig Cell Cholera Toxin Progesterone Production Steroid Biosynthesis 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Mario Ascoli
    • 1
    • 2
    • 3
  • Dale A. Freeman
    • 1
    • 2
  1. 1.Division of EndocrinologyVanderbilt Medical SchoolNashvilleUSA
  2. 2.Departments of MedicineVanderbilt Medical SchoolNashvilleUSA
  3. 3.Departments of BiochemistryVanderbilt Medical SchoolNashvilleUSA

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