Regulation of Granulosa Cell Responsiveness to Gonadotropins: Actions of Epidermal and Platelet-Derived Growth Factors

  • Judith S. Mondschein
  • David W. Schomberg
Part of the Biochemical Endocrinology book series (BIOEND, volume 1)


The concept of pituitary gonadotropins as regulators of follicular and luteal development and function is central to our understanding of ovarian physiology. Patterns of gonadotropin secretion are superimposed upon patterns of target cell gonadotropin receptor levels (Richards and Midgley, 1976). The result of this well-coordinated series of events is a normal estrus or menstrual cycle. Steroid hormones provide a second level of regulation of these processes. As early as 1940 it was observed that estrogen enhanced ovarian responsiveness to gonadotropins (Pencharz, 1940). More recent studies have suggested roles for estrogens , androgens, and progestins in various aspects of ovarian physiology and pathophysiology (McNatty et al., 1979; Louvet et al., 1975; Schomberg, 1979; Schreiber and Hsueh, 1979; and references therein). The observation that growth factors can modulate follicle-stimulating hormone (FSH)-dependent luteinizing hormone (LH) receptor induction in vitro (Mondschein and Schomberg, 1981a) introduced the possibility of a third level of regulation: the growth factors, known primarily for their mitogenic effects on cultured cells, may represent a broad class of compounds which interact with more classic gonadotropic and steroidal mechanisms to determine the course of follicular and luteal development and function.


Epidermal Growth Factor Receptor Granulosa Cell Luteal Cell Leydig Tumor Cell Ovarian Granulosa Cell 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Judith S. Mondschein
    • 1
  • David W. Schomberg
    • 1
  1. 1.Departments of Obstetrics and Gynecology and PhysiologyDuke University Medical CenterDurhamUSA

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