Utilization of Lipoprotein-Carried Cholesterol for Steroidogenesis by Rat Luteal Tissue
Steroidogenic cells have the capacity to synthesize de novo the obligate precursor of their secretory products, cholesterol. However, it has become apparent that many glands rely upon extracellular sterol as substrate (Brown et al., 1979; Gwynne and Strauss, 1982; Strauss et al., 1981). This seems to be particularly true of tissues which secrete large quantities of steroid, such as the corpus luteum.
KeywordsGranulosa Cell Cholesteryl Ester Sterol Ester Luteal Cell Luteinized Granulosa Cell
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- Brown, M. S., Kovanen, P. T., and Goldstein, J. L., 1979, Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex, Recent Prog. Hormone Res. 35:215.Google Scholar
- Tanaka, T., Billheimer, J. T., and Strauss, J. F. III, 1982, Luteinized rat ovaries contain a sterol binding protein similar to hepatic SCP . Abstracts, 64th Annual Meeting of the Endocrine Society, San Francisco, CA Abstract 402.Google Scholar
- Tureck, R. W., Wilburn, A. B., Gwynne, J. T., Paavola, L. G., and Strauss, J. F. III, 1983, The role of lipoproteins in steroidogenesis by human luteinized granulosa cells in culture, J. Steroid. Biochem. in press.Google Scholar
- Veldhuis, J. D., Klase, P. A., Gwynne, J. T., and Strauss, J. F. III, 1982, Low density lipoproteins (LDL) augment progesterone biosynthesis by swine granulosa cells in vitro: Relation of LDL effects to estrogen and gonadotropin action. Biol. Reprod. 26(Suppl. 1): 12.Google Scholar