Regulation of Sertoli Cell Responsiveness: Desensitization of Adenylyl Cyclase by FSH, Isoproterenol and Glucagon

  • H. Attramadal
  • T. Jahnsen
  • F. Le Gac
  • V. Hansson
Part of the Biochemical Endocrinology book series (BIOEND, volume 1)


The function of the Sertoli cell is to provide a milieu in which germ cell proliferation and differentiation can take place. It is now believed that hormones regulating spermatogenesis are mediating their effects via the Sertoli cell (Hansson et al., 1976). The Sertoli cell is a target cell for both FSH (Hansson et al., 1973; Hansson et al., 1974b), and androgens (Hansson et al., 1974a; Hansson et al., 1975; Mulder et al., 1975; Sanborn et al., 1977). Furthermore, cAMP formation in cultured immature Sertoli cells is stimulated by β1-andrenergic agonists (Verhoeven et al., 1979, 1981) and glucagon (Attramadal, H., Jahnsen, T., and Hansson, V., unpublished). However, neither β1-adrenergic hormones nor glucagon have yet been ascribed any role in the regulation of spermatogenesis in vivo. However, it provides a system in which three agonists are acting on the same adenylyl cyclase system and facilitates studies on hormone-specific densensitization in living cells and in membrane particles.


Sertoli Cell Adenylyl Cyclase Adenylyl Cyclase Activity cAMP Formation Dibutyryl cAMP 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • H. Attramadal
    • 1
  • T. Jahnsen
    • 1
  • F. Le Gac
    • 1
  • V. Hansson
    • 1
    • 2
  1. 1.Institute of PathologyRikshospitaletNorway
  2. 2.Institute of Medical BiochemistryUniversity of OsloNorway

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