Regulation of Sertoli Cell Responsiveness: Desensitization of Adenylyl Cyclase by FSH, Isoproterenol and Glucagon
The function of the Sertoli cell is to provide a milieu in which germ cell proliferation and differentiation can take place. It is now believed that hormones regulating spermatogenesis are mediating their effects via the Sertoli cell (Hansson et al., 1976). The Sertoli cell is a target cell for both FSH (Hansson et al., 1973; Hansson et al., 1974b), and androgens (Hansson et al., 1974a; Hansson et al., 1975; Mulder et al., 1975; Sanborn et al., 1977). Furthermore, cAMP formation in cultured immature Sertoli cells is stimulated by β1-andrenergic agonists (Verhoeven et al., 1979, 1981) and glucagon (Attramadal, H., Jahnsen, T., and Hansson, V., unpublished). However, neither β1-adrenergic hormones nor glucagon have yet been ascribed any role in the regulation of spermatogenesis in vivo. However, it provides a system in which three agonists are acting on the same adenylyl cyclase system and facilitates studies on hormone-specific densensitization in living cells and in membrane particles.
KeywordsSertoli Cell Adenylyl Cyclase Adenylyl Cyclase Activity cAMP Formation Dibutyryl cAMP
Unable to display preview. Download preview PDF.
- Hansson, V., Reusch, E., Trygstad, O., Torgersen, O., Ritzén, E. M., and French, F. S., 1973, FSH stimulation of testicular androgen binding protein (ABP), Nature, New Biol., 246:_.Google Scholar
- Hansson, V., Ritzén, E. M., French, F. S., and Nayfeh, S. N., 1975, Androgen transport and receptor mechanisms in the testis and epididymis, in: “Handbook of Physiology,” Section 7, Vol. 5, D. W. Hamilton, R. 0. Greep, eds., pp. 173–202, American Physiology Society, USA.Google Scholar
- Hansson, V., Jegou, B., Attramadal, H., Jahnsen, T., Le Gac, F., Tvermyr, M., Frøysa, A., and Horn, R., 1983, Regultion of Sertoli cell secretion and response, in: “Recent Advances of Male Reproduction,” d’Agata, ed., Raven Press, USA (in press).Google Scholar
- Hormone receptors, and cyclic AMP: Their role in target cell refractoriness, Curr. Top. Cell. Reg., 17:205.Google Scholar