Biochemical Pharmacology of Substance P Receptors
Neuronal peptides are recent additions to the catalogue of substances which may act as intracellular signals in the nervous system. As a result, little is known of the receptors or biochemical mechanisms mediating their actions. Substance P (SP) was the first peptide for which a neurotransmitter role was proposed, and is currently speculated to be a sensory transmitter in the spinal cord. We have investigated SP receptors in both CNS and peripheral tissues by ligand recognition, closely-coupled biochemical events, and final biological responses. Herein, we will use the analysis of SP receptors as an illustration of special problems associated with the study of neuropeptides.
KeywordsBiochemical Pharmacology Ligand Recognition Tachykinin Receptor Sensory Transmitter Cyclic Nucleotide Level
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