Selective Tolerance Development Facilitates a Differentiation of Multiple Opiate Receptors
Tests with opiate-sensitive, isolated tissue preparations, e.g. the guinea-pig ileum, made highly tolerant in vivo to the μ-agonist morphine proved that these were almost unchanged in sensitivity to other types of opioid receptor agonists such as κ-agonists. Thus, the ability to selectively induce tolerance on particular types of opiate receptor represents a valuable tool for the differentiation and characterization of multiple opiate receptors in peripheral tissue preparations. So far, the guinea pig ileum has been found to contain μ- and κ-opiate receptors, whereas μ-, δ- and κ-receptors can be demonstrated in the mouse vas deferens.
KeywordsOpiate Receptor Narcotic Analgesic Endogenous Opioid Peptide Opioid Receptor Agonist Opioid Class
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