Selective Tolerance Development Facilitates a Differentiation of Multiple Opiate Receptors

  • M. Wüster
  • R. Schulz
  • A. Herz
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)


Tests with opiate-sensitive, isolated tissue preparations, e.g. the guinea-pig ileum, made highly tolerant in vivo to the μ-agonist morphine proved that these were almost unchanged in sensitivity to other types of opioid receptor agonists such as κ-agonists. Thus, the ability to selectively induce tolerance on particular types of opiate receptor represents a valuable tool for the differentiation and characterization of multiple opiate receptors in peripheral tissue preparations. So far, the guinea pig ileum has been found to contain μ- and κ-opiate receptors, whereas μ-, δ- and κ-receptors can be demonstrated in the mouse vas deferens.


Opiate Receptor Narcotic Analgesic Endogenous Opioid Peptide Opioid Receptor Agonist Opioid Class 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Wüster
    • 1
  • R. Schulz
    • 1
  • A. Herz
    • 1
  1. 1.Department of NeuropharmacologyMax-Planck-Institut für PsychiatrieMünchen 40W. Germany

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