Guanine Nucleotide Regulation of Agonist Binding to Hepatic α1-Adrenergic Receptors

  • M. Goodhardt
  • N. Ferry
  • J. Hanoune
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)


Guanine nucleotides exert multiple regulatory effects on adenylate cyclase-linked receptors, mediated through specific guanine nucleotide binding protein(s), which serve to transmit the hormonal signal from the receptor to the catalytic moiety of the adenylate cyclase system [1]. The role of guanine nucleotides is still unclear in the case of the α1-adrenergic receptor, which is not coupled to adenylate cyclase activity [2, 3].


Adenylate Cyclase Guanine Nucleotide Adenylate Cyclase Activity Agonist Binding Adenylate Cyclase System 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Goodhardt
    • 1
  • N. Ferry
    • 1
  • J. Hanoune
    • 1
  1. 1.Unité INSERMHópital Henri MondorCréteilFrance

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