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In Vitro Regulation of β-Adrenergic Receptors

  • Perry B. Molinoff
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)

Abstract

A major goal of pharmacology is to define at a molecular level the mechanisms through which an agonist can elicit a biological response. Antagonists, although often structurally similar to agonists, appear to occupy the same receptor without eliciting a biological response. With β-adrenergic receptors, the response usually entails an increase in cyclic AMP levels. Studies of the interactions of agonists and antagonists with these receptors have revealed differences which may contribute to our understanding of the ability of an agonist to elicit a biological response. Among these differences are differential effects of ions, purine nucleotides, temperature and sulphydryl alkylating agents. Agonist-specific phenomena have also been revealed when receptors are studied on intact cells as compared to membrane fragments prepared from the same cells.

Keywords

Adenylate Cyclase Ternary Complex Guanine Nucleotide Full Agonist Agonist Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Perry B. Molinoff
    • 1
  1. 1.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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