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Antibody-Targeted Liposomes: Specific Cell Binding and Cytotoxicity

  • T. D. Heath
  • K. Bragman
  • D. Paphadjopoulos
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)

Abstract

In relation to delivering anti-tumour agents, the interaction of antibody-conjugated liposomes with various cell types in vitro has been studied. Targeted liposomes bearing monoclonal anti H2Kk antibody bind in 6–40 fold greater amounts to cells expressing H2Kk than liposomes bearing anti sheep erythrocyte antibody (non-targeted). The difference between targeted and non-targeted liposomes is increased by incubation in serum. Targeted binding is blocked by soluble anti H2Kk, and is partially inhibited by azide and 2-deoxy-d-glucose.

Keywords

Chronic Myelogenous Leukaemia Myelogenous Leukaemia Human Erythrocyte Cancer Research Institute Editorial Note 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • T. D. Heath
    • 1
  • K. Bragman
    • 1
  • D. Paphadjopoulos
    • 1
  1. 1.Cancer Research InstituteUniversity of California School of MedicineSan FranciscoUSA

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