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The Ldl Receptor: Functional Studies And Partial Characterization

  • U. Beisieger
  • W. J. Schneider
  • M. S. Brown
  • J. L. Goldstein
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)

Abstract

The receptor for LDL (low-density lipoprotein) is a cell-surface protein that binds LDL, the major cholesterol-transport protein in plasma ([1], & see #C-6, this vol.). Binding leads to cellular uptake of LDL by absorptive endocytosis in coated pits. The LDL is digested within lysosomes, providing the cell with cholesterol for new membrane synthesis. In patients with familial hypercholesterolaemia (FH), LDL receptor function is diminished. As a result, LDL is not removed normally from the circulation and it accumulates to high levels in plasma, ultimately producing atherosclerosis [1].

Keywords

Familial Hypercholesterol Normal Human Fibroblast Membrane Synthesis Bovine Adrenal Cortex Familial Hypercholesterol Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Goldstein, J.L. & Brown, M.S. (1981) Med. Clin. N. Am. 66, 335–362.Google Scholar
  2. 2.
    Beisiegel, U., Schneider, W.J., Goldstein, J.L., Anderson, R.G.W. & Brown, M.S. (1981) J. Biol. Chem. 256, 11923–11931.Google Scholar
  3. 3.
    Schneider, W.J., Beisiegel, U., Goldstein, J.L. & Brown, M.S. (1982) J. Biol. Chem. 257, 2664–2673.Google Scholar
  4. 4.
    Beisiegel, U., Schneider, W.J., Brown, M.S. & Goldstein, J.L. (1982) J. Biol. Chem. 257, 13150–13156.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • U. Beisieger
    • 1
  • W. J. Schneider
    • 1
  • M. S. Brown
    • 1
  • J. L. Goldstein
    • 1
  1. 1.Department of Molecular GeneticsUTHSC-DallasDallasUSA

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