Abstract
The receptor for LDL (low-density lipoprotein) is a cell-surface protein that binds LDL, the major cholesterol-transport protein in plasma ([1], & see #C-6, this vol.). Binding leads to cellular uptake of LDL by absorptive endocytosis in coated pits. The LDL is digested within lysosomes, providing the cell with cholesterol for new membrane synthesis. In patients with familial hypercholesterolaemia (FH), LDL receptor function is diminished. As a result, LDL is not removed normally from the circulation and it accumulates to high levels in plasma, ultimately producing atherosclerosis [1].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Goldstein, J.L. & Brown, M.S. (1981) Med. Clin. N. Am. 66, 335–362.
Beisiegel, U., Schneider, W.J., Goldstein, J.L., Anderson, R.G.W. & Brown, M.S. (1981) J. Biol. Chem. 256, 11923–11931.
Schneider, W.J., Beisiegel, U., Goldstein, J.L. & Brown, M.S. (1982) J. Biol. Chem. 257, 2664–2673.
Beisiegel, U., Schneider, W.J., Brown, M.S. & Goldstein, J.L. (1982) J. Biol. Chem. 257, 13150–13156.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Beisieger, U., Schneider, W.J., Brown, M.S., Goldstein, J.L. (1984). The Ldl Receptor: Functional Studies And Partial Characterization. In: Reid, E., Cook, G.M.W., Morré, D.J. (eds) Investigation of Membrane-Located Receptors. Methodological Surveys in Biochemistry and Analysis, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4631-9_34
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4631-9_34
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4633-3
Online ISBN: 978-1-4684-4631-9
eBook Packages: Springer Book Archive