Hepatic Growth Hormone/Prolactin Receptors in Male Rats: Intracellular Localization, Induction And Internalization
Receptors that specifically bind lactogenic hormones such as prolactin (Prl) and human growth hormone (hGH) are present in the female rat liver, but at a much lower level in the male [l]. This sex difference can be abolished by continuously infusing low doses of hGH into the male rat for 5–7 days . Subcellular fractionation and iodinated ligand binding studies have shown that Prl/hGH receptors are located mainly in the Golgi complex (G.a.) as well as in the plasma membrane (p.m.) in female liver . Lysosome-rich fractions from female liver also contain binding sites for lactogenic hormones ; but whether such sites are constitutive components of the lysosomal compartment was not elucidated.
KeywordsLactogenic Hormone Human Growth Hormone Lysosomal Compartment Osmotic Minipumps Female Liver
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