Hepatic Growth Hormone/Prolactin Receptors in Male Rats: Intracellular Localization, Induction And Internalization

  • Göran Andersson
  • Gunnar Norstedt
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)


Receptors that specifically bind lactogenic hormones such as prolactin (Prl) and human growth hormone (hGH) are present in the female rat liver, but at a much lower level in the male [l]. This sex difference can be abolished by continuously infusing low doses of hGH into the male rat for 5–7 days [2]. Subcellular fractionation and iodinated ligand binding studies have shown that Prl/hGH receptors are located mainly in the Golgi complex (G.a.) as well as in the plasma membrane (p.m.) in female liver [3]. Lysosome-rich fractions from female liver also contain binding sites for lactogenic hormones [4]; but whether such sites are constitutive components of the lysosomal compartment was not elucidated.


Lactogenic Hormone Human Growth Hormone Lysosomal Compartment Osmotic Minipumps Female Liver 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Göran Andersson
    • 1
  • Gunnar Norstedt
    • 2
  1. 1.Departments of Pathology, Karolinska InstitutetHuddinge University HospitalHuddingeSweden
  2. 2.Medical Nutrition, Karolinska InstitutetHuddinge University HospitalHuddingeSweden

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