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Plasma Lipoproteins and the Regulation of Cellular Function

  • J. S. Owen
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)

Abstract

Cholesterol and phospholipid (PL) molecules on the surface of lipoproteins exchange with their counterparts in plasma membranes (p.m.), whose lipid composition and fluidity might thus change if lipoprotein surface lipids change. Thereby p.m. receptor functions, albeit properties of the membrane proteins, might be influenced. Plasma lipoproteins, like other circulating molecules, regulate cellular metabolism through interaction with cell surfaces, apparently involving binding to specific receptors via apoprotein. Derangements in lipoprotein composition may not only affect lipid transport but also entail poorly understood. metabolic and cellular dysfunctions and so be clinically relevant.

Keywords

Membrane Fluidity Plasma Lipoprotein Fatty Acyl Chain Membrane Lipid Composition Polyunsaturated Fatty Acyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Owen, J.S. & Mclntyre, N. (1982) Trends Biochem. Sci.56, 95–98.CrossRefGoogle Scholar
  2. 2.
    Op den Kamp, J.A.F. (1979) Ann. Rev. Biochem.48, 47–71.CrossRefGoogle Scholar
  3. 3.
    Lange, Y. & Slayton, J.M. (1982) J. Lipid Res.23, 1121–1127.Google Scholar
  4. 4.
    Bruckdorfer, K.R. & Graham, J.M. (1976) in Biological Membranes V. 3 (Chapman, D. & Wallach, D.F.H., eds.), Academic Press, London, 103–152.Google Scholar
  5. 5.
    Owen, J.S., Brouckdorfer, K.R., Day, R.C. & Mclntyre, N. (1982) J. Lipid Res.23, 124–132.Google Scholar
  6. 6.
    Shastri, K.M., Carvalho, A.C. & Lees, R.S. (1980) J. Lipid Res.21, 467–472.Google Scholar
  7. 7.
    Owen, J.S., Hutton, R.A., Bruckdorfer, K.R., Day, R.C. & Mclntyre, N. (1981) J. Lipid Res.22, 423–430.Google Scholar
  8. 8.
    Reichl, D., Myant, N.B. & Pflug, J.J. (1977) Biochim. Biophys. Acta489, 98–105.CrossRefGoogle Scholar
  9. 9.
    Roheim, P.S., Carey, M., Forte, T. & Vega, G.L. (1979) Proc. Nat. Acad. Sci.76, 4646–4649.CrossRefGoogle Scholar
  10. 10.
    Rao, G.A., Siler, K. & Larkin, E.C. (1979) Lipids14, 30–38.CrossRefGoogle Scholar
  11. 11.
    Tahin, Q.S., Blum, M. & Carafoli, E. (1981) Eur. J. Biochem.121, 5–13.CrossRefGoogle Scholar
  12. 12.
    Foot, M., Cruz, T.F. & Clandinin, M.T. (1982) Biochem. J.208, 631–640.Google Scholar
  13. 13.
    Owen, J.S. & Gillett, M.P.T. (1983) Biochem. Soc. Trans., in press.Google Scholar
  14. 14.
    Shinitzky, M. & Sourojon, M. (1979) Proc. Nat. Acad. Sci. 76, 4438–4440.CrossRefGoogle Scholar
  15. 15.
    Armond, P.A. & Staehelin, L.A. (1979) Proc. Nat. Acad. Sci.76, 1901–1905.CrossRefGoogle Scholar
  16. 16.
    Dragsten, P., Henkart, P., Blumenthal, R., Weinstein, J. & Schlessinger, J. (1979) Proc. Nat. Acad. Sci.76, 5163–5167.CrossRefGoogle Scholar
  17. 17.
    Rimon, G., Hanski, E., Braun, S. & Levitzki, A. (1978) Nature276, 394–396.CrossRefGoogle Scholar
  18. 18.
    Brown, M.S., Kovanen, P.T. & Goldstein, J.L. (1981) Science212, 628–635.CrossRefGoogle Scholar
  19. 19.
    Gianturco, S.H., Bradley, W.H., Gotto, A.M., Morrisett, J.D. & Peavey, D.L. (1982) J. Clin. Invest.70, 168–178.CrossRefGoogle Scholar
  20. 20.
    Henriksen, T., Mahoney, E.M. & Steinberg, D. (1981) Proc. Nat. Acad. Sci.78, 6499–6503.CrossRefGoogle Scholar
  21. 21.
    Chen, Y.-D.I., Kraemer, F.B. & Reaven, G.M. (1980) J. Biol. Chem.255, 9162–9167.Google Scholar
  22. 22.
    Attie, A.D., Pittman, R.C. & Steinberg, D. (1982) Hepatology2, 269–281.CrossRefGoogle Scholar
  23. 23.
    Shore, V. & Shore, B. (1975) Biochem. Biophys. Res. Comm.65, 1250–1256.CrossRefGoogle Scholar
  24. 24.
    Pairault, J., Levillier, J. & Chapman, M.J. (1977) Nature269, 607–609.CrossRefGoogle Scholar
  25. 25.
    Ghiselli, G., Sirtori, C.R. & Nicosia, S. (1981) Biochem. J.196, 899–902.Google Scholar
  26. 26.
    Thomopoulos, P., Berthelier, M., Lagrange, D., Chapman, M.J. & Laudat, M.-H. (1978) Biochem. J.176, 169–174.Google Scholar
  27. 27.
    Hui, D.Y. & Harmony, J.A.K. (1979) Bioehim. Biophys. Acta550, 425–434.CrossRefGoogle Scholar
  28. 28.
    Nordøy, A., Svensson, B., Wiebe, D. & Hoak, J.C. (1978) Circulation Res. 43, 527–534.CrossRefGoogle Scholar
  29. 29.
    Beitz, J. & Forster, W. (1980) Bioehim. Biophys. Acta620, 352–355.CrossRefGoogle Scholar
  30. 30.
    Chisari, F.V. (1977) J. Immunol.119, 2129–2136.Google Scholar
  31. 31.
    Avila, E.M., Holdsworth, G., Sasaki, N., Jackson, R.L. & Harmony, J.A.K. (1982) J. Biol. Chem.257, 5900–5909.Google Scholar
  32. 32.
    Levy, G.A., Schwartz, B.S., Curtiss, L.K. & Edgington, T.S. (1981) J. Clin. Invest.67, 1614–1622.CrossRefGoogle Scholar
  33. 33.
    Chapman, H.A. & Hibbs, J.B. (1977) Science197, 282–285.CrossRefGoogle Scholar
  34. 34.
    Curtiss, L.K. & Edgington, T.S. (1978) J. Clin. Invest.61, 1298–1308.CrossRefGoogle Scholar
  35. 35.
    Hui, D.Y., Noel, J.G. & Harmony, J.A.K. (1981) Bioehim. Biophys. Acta 66k, 513–526.CrossRefGoogle Scholar
  36. 36.
    Moorhead, J.F., Chan, M.K., El-Nahas, M. & Varghese, Z. (1982) Lancet ii, 1309–1311.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. S. Owen
    • 1
  1. 1.Academic Department of Medicine, Royal Free Hospital School of MedicineUniversity of LondonLondonUK

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